α-glucosidase x ACE x AMYs

Last update 08 May 2025

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α-glucosidaseACEAMYs

100 Clinical Results associated with α-glucosidase x ACE x AMYs

100 Translational Medicine associated with α-glucosidase x ACE x AMYs

0 Patents (Medical) associated with α-glucosidase x ACE x AMYs

Literatures (Medical) associated with α-glucosidase x ACE x AMYs

01 May 2025·International Journal of Biological Macromolecules

Characterization, biofunctionalities, and in vitro gut microbiota modulation of nanoparticles polysaccharides ultrasonically extracted from date seeds

Article

Author: Subhash, Athira ; Abu-Jdayil, Basim ; Jarusheh, Hebah ; Ali, Abdelmoneim ; Liu, Shao-Quan ; Bamigbade, Gafar ; Palmisano, Giovanni ; Kamal-Eldin, Afaf ; Ayyash, Mutamed

Selenium nanoparticles (UP-SeNPs) were synthesized from ultrasonically extracted date seed polysaccharides (UP) using a redox reaction between sodium selenite and ascorbic acid. The UP-SeNPs were effectively characterized for their particles size and surface, elemental compositions; in-vitro digestibility and antioxidant, antimicrobial, prebiotic and gut microbiota modulating potential of the bio accessible fractions. Glucooligosaccharide (GP-NPs) and selenium SeNPs nanoparticles were prepared as controls for biological activities and fecal fermentation. The resulted UP-SeNPs were uniform, spherical, and amorphous with a stable dispersion for 42 days and an average size of 90.5 nm. Compared to native UP and selenite, UP-SeNPs displayed increased antioxidant capacities, including dose-dependent radical scavenging (89 %), DPPH (76.4 %), ABTS (83.3 %), reducing power (809.5 μg/mL), FRAP (798.7 μg/mL), and metal chelating ability (12,230 μg/mL). Additionally, UP-SeNPs exhibited superior α-amylase (74.3 %), α-glucosidase (87 %), and ACE (64 %) inhibitions potential and significant antibacterial effects against several major foodborne pathogens. Probiotic investigations demonstrated the prebiotic impact of UP-SeNPs, supporting in vitro fecal fermentation while maintaining natural gut microbiota diversity. UP-SeNPs effectively reduced the Bacillota-to-Bacteroidota ratio, limiting pathogenic microorganisms and promoting a healthier gut environment. Functional predictions highlighted upregulated metabolic pathways, including SCFA biosynthesis (acetate, propionate, and butyrate) that are essential for preventing gut dysbiosis and maintaining energy homeostasis. UP-SeNPs also improved carbohydrate metabolism and fatty acid biosynthesis, making them readily bioavailable for colonic microbiota. Overall polysaccharide conjugation with selenium nanoparticles delivered resultant NP with improved stability, functionality and bioactive potentials compared to SeNPs on their own. The conjugation was also able to further deliver UP-SeNPs that had prominent prebiotic and gut microbiota modulation potentials.

01 Dec 2024·Food Research International

Impact of pre-fermentative maceration techniques on the chemical characteristics, phenolic composition, in vitro bioaccessibility, and biological activities of alcoholic and acetic fermented products from jaboticaba (Plinia trunciflora)

Article

Author: Gomes, Victor Valentim ; Kempka, Aniela Pinto ; Moroni, Liziane Schittler ; de Sena Aquino, Ana Carolina Moura ; de Mello Castanho Amboni, Renata Dias ; Deolindo, Carolina Turnes Pasini ; Gomes, Victor Valentin ; Costa, Ana Carolina Oliveira ; da Silva Monteiro Wanderley, Bruna Rafaela ; Gonzaga, Luciano Valdemiro ; Fritzen-Freire, Carlise Beddin ; de Lima, Natália Duarte

The jaboticaba is a fruit with a highly promising chemical profile for producing fermented products with biological activity. In this context, evaluating pre-fermentative maceration techniques in jaboticaba fermentations is essential to optimize the extraction of phenolic compounds and other metabolites of interest, imparting antioxidant characteristics to the product and offering potential health benefits. This study evaluated the impact of two pre-fermentative maceration techniques on the phenolic composition, bioaccessibility, and biological activities (α-amylase, α-glucosidase, and ACE inhibition) of alcoholic and acetic fermented products from jaboticaba. Three treatments were performed: one without pre-fermentative maceration and two with maceration, one cold (4 °C for 24 h) and the other thermal maceration (50 °C until 16 °Brix). The resulting musts were subjected to alcoholic and acetic fermentation. The results showed that the fermented products obtained after thermal maceration had higher concentrations of phenolic compounds, with ellagic acid (5393.78 µg/L) standing out for thealcoholic beverage and 2.5-DHBA (1552.33 µg/L) and 3.4-DHB (863.15 µg/L) acids for the vinegar. Regarding bioaccessibility, both pre-fermentative maceration techniques contributed to more bioaccessible compounds (with indices above 20 %) compared to the samples without maceration. A more significant inhibition of α-amylase and α-glucosidase was observed in the samples subjected to thermal maceration, along with notable ACE inhibition. Additionally, the sensitivity of E. coli, S. aureus, L. monocytogenes, and S. Enteritidis to the fermented jaboticaba products was verified, with distinct sensitivity patterns for each type of bacteria. In summary, this study offers a new perspective for valorizing fermented jaboticaba products through pre-fermentative techniques, enriching the understanding of this technique and its potential nutritional and bioactive contributions.

01 Dec 2024·Food Chemistry

Biological activities, Peptidomics and in silico analysis of low-fat Cheddar cheese after in vitro digestion: Impact of blending camel and bovine Milk

Article

Author: Ali, Abdelmoneim H ; Tarique, Mohammad ; Kamal-Eldin, Afaf ; Liu, Shao-Quan ; Öztürk, Hale İnci ; Nemutlu, Emirhan ; Ayyash, Mutamed ; Subhash, Athira ; Eylem, Cemil Can

Cheesemaking with camel milk (CM) presents unique challenges and additional health benefits. This study involved preparing low-fat Cheddar cheese (LFCC) by blending bovine milk (BM) with varying levels of CM. Control cheese was made exclusively with BM. After 180 days of ripening, LFCC samples underwent in vitro digestion to determine antioxidant capacities, α-amylase and α-glucosidase inhibition, and angiotensin-converting enzyme inhibition. The peptide profile of LFCC treatments was analyzed using liquid chromatography-quadrupole-time of flight-mass spectrometry. Antioxidant and biological activities were influenced by BM-CM blends and digestion. At days 120 and 180, the number of αs1-casein-derived peptides increased in all samples except for LFCC made with 15% CM. Generally, 88 peptides exhibited ACE inhibition activity after 120 days of ripening, increasing to 114 by day 180. These findings suggest that ripening time positively affects the health-promoting aspects of functional cheese products.

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