FAR1

Last update 08 May 2025

Basic Info

Synonyms

FAR1, fatty acyl-CoA reductase 1, FLJ22728

+ [3]

Introduction

Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123, PubMed:35238077). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity) (PubMed:24108123, PubMed:35238077).

100 Clinical Results associated with FAR1

100 Translational Medicine associated with FAR1

0 Patents (Medical) associated with FAR1

274

Literatures (Medical) associated with FAR1

01 Apr 2025·Microbial Biotechnology

Establishment of CRISPR‐STAR System to Realise Simultaneous Transcriptional Activation and Repression in Yarrowia lipolytica

Article

Author: Chen, Yaru ; Li, Mengxu ; Liu, Xuanwei ; Wang, Luxin ; Duan, Qiyang ; Huang, Congcong ; Song, Hao ; Cao, Yingxiu ; Xiao, Lin

ABSTRACTThe ability to regulate gene expression in multiple directions is crucial to maximise the production of microbial cell factories. However, the lack of a regulatory tool that can simultaneously activate and repress multiple genes restricts the manipulation diversity of Yarrowia lipolytica, which is an industrial workhorse for bioproduction. To address this issue, we developed a CRISPR scaffold RNAs (scRNAs)‐mediated transcriptional activation and repression (CRISPR‐STAR) platform. Firstly, we evaluated different methods for bidirectional regulation using CRISPR on both endogenous and synthetic promoters in Y. lipolytica, and chose the utilisation of orthogonal scRNAs to recruit activation and inhibition domains. Secondly, CRISPR‐STAR was optimised by the introduction of alternative dCas proteins, scRNA structures and activators. 2.6‐fold and 54.9‐fold activation were achieved for synthetic and endogenous promoters, respectively, when the VPR transcriptional activator was recruited via MS2 hairpin. The repression of several genes was successfully achieved, with repression levels ranging from 3% to 32%, when the MXI1 transcriptional repressor was recruited via PP7 hairpin. Finally, CRISPR‐STAR was applied to enhance fatty alcohol production by activating the FAR gene (encodes fatty acyl‐CoA reductase) and repression of the PEX10 gene (encodes an integral membrane protein required for peroxisome biogenesis and matrix protein import). Compared to the non‐targeting control, the bidirectionally regulated strain showed a 55.7% increase in yield to 778.8 mg/L. Our findings demonstrate that the CRISPR‐STAR platform enables multi‐mode regulation of genes, offering engineering opportunities to improve the productive performance of Y. lipolytica.

01 Apr 2025·Plant Science

A critical review of the importance of Far-Related Sequence (FRS)- FRS-Related Factor (FRF) transcription factors in plants

Review

Author: Dolatabadian, Aria ; Jafari, Fereshteh

Transposable elements have long been recognised as critical drivers of genetic diversity and evolution in plant genomes, influencing various physiological and developmental processes. The transcription factor family FAR-RED ELONGATED HYPOCOTYLS3 (FHY3), and its homologue FAR-RED IMPAIRED RESPONSE1 (FAR1), initially identified as key components of phytochrome A (phyA)-mediated far-red (FR) light signalling in Arabidopsis thaliana, are derived from transposases and are essential for light signal transduction, plant growth, and development. FHY3 and FAR1 are also the founding members of the FAR1-RELATED SEQUENCE (FRS) family, which is conserved across terrestrial plants. While the coding sequences of many putative FRS and FAR1-RELATED FACTOR (FRF) orthologs have been identified in various angiosperm clades, their physiological functions remain largely unexplored. The FRF genes are considered truncated forms of FRS proteins that compete with FRS for DNA binding sites, thereby regulating gene expression. This review highlights recent advances in characterising the molecular mechanisms of FHY3, FAR1, and other members of the FRS-FRF protein family. We examine their roles in key processes such as regulating flowering time, controlling branching, integrating leaf aging and senescence, modulating the circadian clock, maintaining meristem function, starch synthesis, seed germination, and responding to Starch synthesis and carbon starvation. Additionally, we explore their contributions to plant immunity under biotic and abiotic stresses. Finally, we suggest future directions for functional characterising other FRS-FRF family proteins in plants, which could provide deeper insights into their regulatory roles in plant biology.

01 Feb 2025·Plant, Cell & Environment

The Residual Activity of Fatty Acyl‐CoA Reductase Underlies Thermo‐Sensitive Genic Male Sterility in Rice

Article

Author: Zhong, Xiang ; Zhou, Lei ; Wang, Yi‐Chen ; Su, Zhen‐Xin ; Zhang, Zheng ; Yang, Zhong‐Nan ; Zhu, Jun ; Huang, Xue‐Hui ; Ma, Pei‐Yang ; Liu, Xing‐Lu ; Zhu, Ben‐Shun ; Zhang, Yan‐Fei ; Yang, Yan‐Ming

ABSTRACTPhotoperiod/thermo‐sensitive genic male sterility (P/TGMS) is critical for rice two‐line hybrid system. Previous studies showed that slow development of pollen is a general mechanism for sterility‐to‐fertility conversion of TGMS in Arabidopsis. However, whether this mechanism still exists in rice is unknown. Here, we identified a novel rice TGMS line, ostms16, which exhibits abnormal pollen exine under high temperature and fertility restoration under low temperature. In mutant, a single base mutation of OsTMS16, a fatty acyl‐CoA reductase (FAR), reduced its enzyme activity, leading to defective pollen wall. Under high temperature, the mOsTMS16M549I couldn't provide sufficient protection for the microspores. Under low temperature, the enzyme activity of mOsTMS16M549I is closer to that of OsTMS16, so that the imperfect exine could still protect microspore development. These results indicated whether the residual enzyme activity in mutant could meet the requirement in different temperature is a determinant factor for fertility conversion of P/TGMS lines. Additionally, we previously found that res2, the mutant of a polygalacturonase for tetrad pectin wall degradation, restored multiple TGMS lines in Arabidopsis. In this study, we proved that the osres2 in rice restored the fertility of ostms16, indicating the slow development is also suitable for the fertility restoration in rice.

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