HTN3

Last update 08 May 2025

Basic Info

Synonyms

Basic histidine-rich protein, HIS2, His3 1/11

+ [137]

Introduction

Histatin 5 (Hst 5), a fragment of Hst 3, is the major histatin exhibiting antifungal and antibacterial activities (PubMed:10066791, PubMed:11083804, PubMed:11179305, PubMed:11717389, PubMed:12939362, PubMed:15485849, PubMed:2372245, PubMed:8945538). It is effective against pathogenic yeast C. albicans, C. neoformans, C. glabrata and S. cerevisiae as well as ESKAPE bacterial pathogens (PubMed:18974864, PubMed:23613860, PubMed:2372245, PubMed:28261570, PubMed:8945538). Secreted Hst 5 mediates a multi-step intracellular mechanism of action against the pathogen. Depending on peptide concentration and pathogen, uptake across the membrane can occur through transporters, direct interaction with plasma membrane and/or receptor-mediated endocytosis (PubMed:18974864, PubMed:20487276, PubMed:28261570). Binds C. albicans cell wall proteins SSA1 and SSA2 and glycans in an energy-independent manner, then is taken up by the cells through fungal polyamine transporters DUR3 and DUR31 in an energy-dependent manner (PubMed:12761219, PubMed:20487276, PubMed:22033918, PubMed:23613860). Internalized Hst5 is then targeted to the energized mitochondrion to induce reactive oxygen species (ROS) formation and subsequent release of intracellular non-lytic ATP which ultimately leads to fungal cell death (PubMed:10066791, PubMed:11083804, PubMed:11717389). In addition, inhibits C. albicans TRK1 potassium-transporter which causes exudation of intracellular K(+), generating an osmotic imbalance leading to delayed membrane lysis and cell death (PubMed:15485849). Also acts as a potent inhibitor of bacterial proteases such as Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis as well as human metalloproteases MMP2 and MMP9 (PubMed:11179305). The binding of metals such as zinc, copper or nickel with Hst 5 results in the protection of the enamel and antimicrobial activities such as the inhibition of microbial growth by decreasing the metal concentration, the formation of ROS commonly associated with redox-active metals, the induction of membrane disruption mediated by zinc binding (PubMed:19846304, PubMed:28261570, PubMed:28763199, PubMed:32751915). Also involved in coating oral surfaces in the form of a salivary film which reduces colonization by C. albicans on epithelial cell surfaces (PubMed:26379655). Secreted Hst 5 can also internalize mammalian epithelial cells and target the mitochondria although it does not exert cytotoxic effects in these cells (PubMed:32225006). In contrast with Hst 3, not able to promote wound healing in mammalian host cells (PubMed:18650243). Histatin 3 (Hst 3) is mostly involved in cell migration and wound healing in the oral cavity (PubMed:18650243). Also stimulates cell proliferation after binding to heat shock protein HSC70, which enhances HSC70-CDKN1B complex formation and subsequent ubiquitination during G1/S transition (PubMed:26775844). Also displays antifungal activity against pathogenic yeast Candida albicans, however with less effectiveness than Hst 5 (PubMed:11083804, PubMed:3286634). Histatins are cationic and histidine-rich peptides mainly found in the saliva of higher primates (PubMed:3286634). They are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1, Hst 2/HTN1 and Hst 3/HTN3) (PubMed:32225006).

100 Clinical Results associated with HTN3

100 Translational Medicine associated with HTN3

0 Patents (Medical) associated with HTN3

766

Literatures (Medical) associated with HTN3

01 Aug 2025·Talanta

Ni(II) complexes of His2 peptides as multi-responsive electrochemical probes for anion sensing

Article

Author: Wezynfeld, N E ; Goluch, A ; Tobolska, A ; Głowacz, K ; Ciosek-Skibińska, P ; Wróblewski, W

Peptides possessing a histidine residue at the second position (His2) exhibit distinctive coordination properties, effectively binding transition metal cations. The resulting complexes, with labile binding sites, offer advantageous features as potential molecular receptors. In this work, a His2 peptide library was designed to select a sequence that, upon binding Ni(II) ions, would exhibit the most promising properties for anion sensing. Electrochemical techniques were used to characterize the redox properties of the studied Ni(II)-His2 peptide complexes. Subsequently, voltammetric responses of the complexes in the presence of various biologically relevant anions (chlorides, sulfates, acetates, lactates and phosphates) were collected and analyzed using Principal Component Analysis, providing effective anion discrimination based on electrochemical fingerprints. Finally, a simple methodology was proposed to differentiate varying lactate and phosphate concentrations in complex, multi-ion samples, simulating physiological and pathological blood plasma conditions. The results confirm the high application potential of the proposed class of molecular receptors and provide insights into novel anion-sensing strategies utilizing metal-peptide complexes as multi-responsive electrochemical probes.

01 Mar 2025·Journal of Hazardous Materials

Influence of biofilm and calcium carbonate scaling on lead transport in plastic potable water pipes: A laboratory and molecular dynamics study

Article

Author: Fischer, Sarah ; Salehi, Maryam ; Yazdani, Hessam ; Brown, Shawn P ; Datta, Dibya Kanti ; Paramban, Shahbaz

This study investigated lead (Pb) transport through new, biofilm-laden, and calcium carbonate-scaled crosslinked polyethylene (PEX-A) and high-density polyethylene (HDPE) potable water pipes. The research focused on Pb accumulation through short-term exposure incidents (6 h) and Pb release for a longer duration (5 d). A mechanistic investigation of the surface morphology variations of plastic pipes following biofilm and scale formation has been conducted. The nanoscale surface asperities in new PEX-A pipes and microscale roughness features in new HDPE pipes supported the differences in biofilm abundance, scale formation, and metal uptake results between these two pipes. Biomass analysis and dissolved organic matter (DOM) quantification using three-dimensional excitation emission spectroscopy revealed a greater release of biofilm biomass during the Pb accumulation and release experiments from biofilm-laden HDPE pipes. Both biofilm-laden plastic pipes accumulated a significantly greater level of Pb compared to the new and scaled pipes. However, scaled pipes showed the highest Pb release, while biofilm-laden pipes released the least. Additionally, investigation of Pb²⁺ exchange from the pipe surface in the presence of Ca²⁺ in the solution indicated that divalent cations in water can trigger further Pb release from the pipe surface. Furthermore, the molecular dynamics simulation provided valuable insights into the interaction between different pipe surfaces with Pb with respect to affinity and binding energy.

01 Jan 2025·BIO-PROTOCOL

Temporally and Spatially Controlled Age-Related Prostate Cancer Model in Mice

Article

Author: Rivero, Seleste ; Zhang, Qiuyang ; Shen, Keyi ; Liu, Sen ; Li, Zixuan

The initiation and progression of prostate cancer (PCa) are associated with aging. In the history of age-related PCa research, mice have become a more popular animal model option than any other species due to their short lifespan and rapid reproduction. However, PCa in mice is usually induced at a relatively young age, while it spontaneously develops in humans at an older age. Thus, it is essential to develop a method by which the PCa initiation and progression timeline can be strictly controlled to mimic human physiological conditions. One milestone in this field was the identification of the prostate-specific transcription factor, Probasin (Pb), which allowed for the prostate-specific expression of genes knocked into the mice's genome. Another milestone is the establishment of the preclinical mouse model with Pten conditionally knocked out in the prostate tissue, which closely mimics the formation and growth of human PCa. Hereby, we present the prostate-specific temporally and spatially controlled Pten knockout PCa mouse model that can be induced using an adenovirus-based Cre-LoxP system. The Cre recombinase (Cre) is inserted into an adenovirus vector. Unlike Pb-Cre knock-in models (which are spatially but not temporally controlled), the expression of Cre is activated to knock out Pten from the mice's prostate epithelial cells once injected. The viral delivery procedures strictly control the location and time of Pten knockout. This novel approach provides a powerful age-related murine model for PCa, emphasizing the effect of aging on prostate carcinogenesis. Key features • In vivo delivery of Cre recombinase adenovirus (Ad-Cre-Luc) in Pten LoxP/LoxP (L/L) mice. • Generation of Cre-expressing Ad-Cre-Luc-mediated ablation of Pten in anterior prostate epithelial cells of adult Pten L/L mice at different ages. • The Ad-Cre-Luc-mediated ablation of Pten leads to hyperplasia that progresses through prostatic intraepithelial neoplasia (PIN) to adenocarcinoma. • PIN refers to the non-cancerous growth of epithelial cells in the prostate tissue-not cancer but a precursor of prostate cancer [1].

News (Medical) associated with HTN3

24 Jun 2021

·www.globenewswire.com

Montero Reports Drill Results for all Zone at the Isabella

TORONTO, June 24, 2021 (GLOBE NEWSWIRE) -- Montero Mining and Exploration Ltd. (TSX-V: MON) (“Montero” or the “Company”) has completed a total 19 diamond drill holes over 2,088 metres to test 4 vein target areas (Figure 1) at its Isabella gold-silver project in Chile. All intersected quartz veins. The assay results for all half-core samples have been received from Andes Analytical Assay (“AAA”) and ALS in Santiago. Montero previously reported assay results for 10 holes completed within Target Area A (April 4, 2021). Assay results from 9 drill holes (ISB20-11 to ISB20-19) testing vein Target Areas B, C and D follow. Figure 1 is available at Dr. Tony Harwood, President of Montero commented, “Initial shallow drilling at Isabella has been completed over 4 vein target areas. Drilling intersected quartz veins and surrounding leucogranite, however, the assay results received show significantly lower Au-Ag values than indicated in surface vein samples. The target areas drilled represent less than 30% of the granite contact where mineralized quartz veins have been identified over a 25 km length suggesting a large gold system. The Company is evaluating all drill results and previous work to determine where additional exploration at Isabella should be focused.” TARGET AREA B Six drill holes tested a north-east trending, structurally controlled, high-grade Au-Ag bearing quartz veins exposed at surface (Figure 2). The veins were previously mapped and sampled over a distance of approximately 300 metres strike length. Previous sampling of the veins returned consistently high Au and Ag grades up to 28.2 g/t Au and 36.2 g/t Ag. A narrow 15 cm wide vein exposed in the north-eastern extents of the vein system contained coarse electrum from a narrow vein exposed immediately east of Drillhole ISB20-14. Previous workers trenched across one vein returning 6.5 g/t Au over 5 m and the property owner also opened the Antonia adit underneath the veins and intersected a 1.5 m wide vein with reported assays of 21 g/t Au and 70 g/t Ag at a vertical depth of about 25 metres. Figure 2 is available at The Drillholes were designed to intersect exposed veins at a vertical depth of 30-50 m. All holes with the exception of Drillhole ISB20-19, located about 500 m to the south-west in Figure 2, intersected quartz veins hosted within a muscovite leucogranite. Drillholes ISB20-16 and ISB20-18 intersected quartz veins of 7.8 metre and 7.7 metres in width, respectively. The assays of cut half-core samples from these veins returned low-grade Au-Ag contents (Table 1). In Drillhole ISB20-16 a 6.9 metre interval returned 0.23 g/t Au in from 91.5 m to 98.4 m with a high of 0.53 g/t Au from 96.5 m to 97.5 m. Drillhole ISB20-16 which was drilled to south-east intersected 2 separate veins of 2.3 m and 2 m width within a wider 7.7 metre zone of narrow quartz stringer veins. These intervals returned 2.3 m of 0.46 g/t Au from 95.2 m to 96.5 m and 2 m of 0.19 g/t Au from 63.2 m to 65.2 m (Table 1). There was no coincident increase in other elements analysed. However, a 1 m wide sample leucogranite with numerous narrow quartz stringer veins from 80.5 m to 81.5 m returned 13 g/t Ag, 0.13% As, 0.57% Pb and 0.81% Zn with associated a highly anomalous 18 ppm Hg. Other assays values indicating an increase of epithermal vein associated elements at depth include 1 m of 0.18 g/t Au, 5 g/t Ag from 105.5 m to 106.5 m in Drillhole ISB20-16 and 1 m of 1,325 ppm Ba from 89.2 m to 90.2 m in Drillhole ISB20-15. Such intersections suggest presence of superimposed (telescoped) mineral systems within the host structure and the potential for higher grades at depth. Figure 3 is available at Figure 4 is available at TARGET AREA C Drillholes ISB20-11 and ISB20-12 were completed to test mineralized quartz veins as defined by surface mapping and sampling. Previous work defined multiple north-east trending quartz veins on surface over a distance of 350 m and over a lateral extent of 200 m. Surface chip sampling of exposed veins returned assays of up to 48 g/t Au and 263 g/t Ag. The Drillholes here were designed to intersect the assumed vertical extent of the veins at 30-50 m depth. The Drillholes intersected low-grade 0.11 to 0.19 g/t Au within narrow zones of quartz veining and brecciation within a fine-medium-grained equigranular leucogranite (Table 1). Drillhole ISB20-11 displays a zone of quartz veins hosted within a potassic-altered, equigranular leucogranite (Figure 5). The assays from 27.9 m to 28.9 m to contain 0.11 g/t Au, 12 g/t Ag, and anomalous 255 ppm As, and 263 ppm Pb. Figure 5 is available at TARGET AREA D Drillhole ISB20-17 was drilled to test the continuity of a mineralized quartz vein between a small artisanal pit and veins exposed by trenching. Previous surface samples of exposed vein returned 6.4 g/t Au, 98 g/t Au from the pit and 2.7 g/t Au, 207 g/t Ag over 1 m from a vein exposed in the trench. Drilling intersected a 24 m wide zone of altered leucogranite containing several narrow (<10 cm wide) quartz veins and numerous quartz-pyrite stringer veins (<1 cm) within altered leucogranite. Assay intersections include 1 m of 0.41 g/t Au, 6 g/t Ag from 31.3 m to 32.3 m (Figure 6) and 1 m of 0.96 g/t Au, 69 g/t Ag from 41.9 m to 42.9 m. These intervals also contain increased concentrations of Cu, Pb and Zn with assays of 0.5% Pb and 0.7% Zn within the latter intersection. Figure 6 is available at SUMMARY The Isabella district is host to an extensive system of mineralized quartz veins located at the granite sediment contact and often associated within a quartz, sericite and pyrite altered leucogranite. The drilling confirmed the veins to be structurally controlled and the common occurrence of quartz crystal-lined open cavities within the veins suggests that the host structures were either open or reopened during vein formation and were the site of repeated faulting as indicated by the presence of narrow zones of fault-breccia along vein margins. Surface sampling of quartz veins has shown that the entire 25 km of strike at Isabella is mineralised with Au and Ag. The drilling of these quartz veins at a shallow depth has not confirmed the expected high values of Au and Ag but it has confirmed that low grade Au and Ag also occurs in the leucogranite which provides an additional target at Isabella. The Company’s is reviewing results to determine the next phase of geological programs. The Company has yet to test the sedimentary target due to access issues. While the Company was unable to intercept the same gold and silver values from surface in shallow drilling of the vein systems, further mapping and sampling is being completed to better understand the geological system and these preliminary drill results. Qualified Person This press release was reviewed and approved by Sr. Marcial Vergara B.Sc. who is resident of Chile and a Qualified Person for the purpose of National Instrument 43-101 and a technical advisor to Montero. Mr. Vergara has visited the property and reviewed previous sampling techniques and analysis and supervised Montero sample collection and analyses. Sr. Vergara has extensive experience in gold exploration in Chile. The core received from drilling Target areas B, C, and D was logged by Company geologists. Selected intervals of drill core were cut in half using a rock saw. Samples were submitted in batches of 30 samples with each batch contained a 1 blank and 1 certified reference material sample for QA/QC. Sample homogeneity was confirmed by submitting additional half-core samples to AAA and also with submission of prepared AAA sample pulps to the ALS laboratory in Santiago for check assay. There were no material differences between the half-core assay results obtained from AAA or the corresponding check assays of sample pulps from ALS. All samples were transported, and hand delivered by a Montero geologist the assay laboratory under the supervision of the Qualified Person. About Montero Montero is a junior exploration company focused on finding, exploring, and advancing significant gold deposits in Chile. The Company is in the process of relinquishing its portfolio of battery metal projects in Africa to focus on gold opportunities in Chile. Montero’s board of directors and management have an impressive track record of successfully discovering and advancing precious metal projects. Montero trades on the TSX Venture Exchange under the symbol MON and has 38,647,485 shares outstanding. For more information, contact: Montero Mining and Exploration Ltd. Dr. Tony Harwood, President and Chief Executive Officer E-mail: ir@monteromining.com Tel: +1 416 840 9197 | Fax: +1 866 688 4671 Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING INFORMATION: This news release includes certain "forward-looking information" within the meaning of applicable Canadian securities laws. Forward looking information includes, but is not limited to, statements, projections, and estimates. Generally, forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “expects” or “does not expect”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will be taken”, “occur” or “be achieved”. Such information is based on information currently available to Montero and Montero provides no assurance that actual results will meet management's expectations. Forward-looking information by its very nature involves inherent risks and uncertainties that may cause the actual results, level of activity, performance, or achievements of Montero to be materially different from those expressed or implied by such forward-looking information. Actual results relating to, among other things, completion of the HOA, results of exploration, project development, reclamation and capital costs of Montero’s mineral properties, and financial condition and prospects, could differ materially from those currently anticipated in such statements for many reasons such as: an inability to complete the HOA on the terms as announced or at all; changes in general economic conditions and conditions in the financial markets; changes in demand and prices for minerals; litigation, legislative, environmental and other judicial, regulatory, political and competitive developments; technological and operational difficulties encountered in connection with Montero’s activities; and other matters discussed in this news release and in filings made with securities regulators. This list is not exhaustive of the factors that may affect any of Montero’s forward-looking statements. These and other factors should be considered carefully and accordingly, readers should not place undue reliance on forward-looking information. Montero does not undertake to update any forward-looking information, except in accordance with applicable securities laws.

28 Oct 2019

·www.globenewswire.com

Osisko Metals Expands Known Mineralization at N204 Zone

MONTREAL, Oct. 28, 2019 (GLOBE NEWSWIRE) -- Osisko Metals Incorporated (the “Company” or “Osisko Metals”) (TSX-V: OM; OTCQX: OMZNF; FRANKFURT: 0B51) is pleased to announce assay results from 8 recently completed drill holes in the N204 Zone, the easternmost deposit in the portfolio, at its wholly owned Pine Point Mining Camp (“PPMC”) in the Northwest Territory. Drill hole N204-19-PP-008 intersected 5.78% zinc and 2.08% lead over 9.00 metres and hole N204-19-PP-001 intersected 6.73% zinc and 1.57% lead over 3.00 metres (see N204 Surface Map). Additionally, the results of re-assaying and re-logging 22 historical holes from the Cominco Limited era between 1964 and 1988 are reported. Of significance are four holes with unsampled mineralization including historical drill hole N204-240 that intersected 4.08% zinc and 1.13% lead over 9.15 metres that is located approximately 100 meters outside of previously modelled resources. Other highlighted intersections are noted in Table 1 below. All intersections are hosted within laterally continuous, stratabound layers within tabular mineralization of the N204 Zone located between 8 to 50 metres vertical depth. The focus of the program in this area is to confirm and expand historical resources, reduce drill spacing, and collect samples for metallurgical tests. Drill hole composites and location details are provided in Tables 2 & 3. Table 1: Selected Drill Highlights Hole NameZoneAreaFrom (m)To (m)Drilled Width (m)True Width (m)Zn (%)Pb (%)Pb + Zn (%)N204-19-PP-001N204N20447.0050.003.003.006.731.578.29N204-19-PP-003N204N20430.0032.002.002.005.701.537.23N204-19-PP-004N204N20443.4549.445.995.994.161.415.57N204-19-PP-005N204N20436.0042.756.756.755.441.226.66N204-19-PP-008N204N20433.0042.009.009.005.782.087.86N204-11**N204N20418.1621.163.003.004.971.706.67N204-234*N204N20439.0043.004.004.004.861.856.72N204-240**N204N20435.0644.209.159.154.081.135.21N204-376*N204N20433.1037.604.504.506.791.868.66 * Re-assay of historical core drilled by Cominco Ltd. ** Mineralized core not previously assayed by Cominco Ltd. Jeff Hussey, President & CEO of Osisko Metals, commented: “We recognized early on that the historical core in the Cominco Limited core inventory stockpiled at Pine Point contained unsampled mineralization that was not of interest before 1988. We are proving that several holes contain significant, economic mineralization in todays context that was not assayed. We will continue to relog and assay historical core from the entire property as a cost effective way to increase value by increasing mineral resources and outlining future exploration targets.” Note regarding mineral resources and Qualified Persons Mr. Robin Adair is the Qualified Person and the Vice President Exploration for Osisko Metals Incorporated. He is responsible for the technical data reported in this news release and a Professional Geologist registered in the North West Territories. Quality Assurance / Quality Control Osisko Metals adheres to a strict Quality Assurance and Quality Control program with regard to core handling, sampling, transportation of samples and lab analyses. Drill core samples from the Pine Point project area were securely transported to its core facility in Hay River, Northwest Territories where they were logged and sampled. Samples selected for assay were shipped via secure transportation to the ALS Canada Ltd.’s preparation facility in Yellowknife. Pulps were analyzed at the ALS Canada Ltd. facility in North Vancouver, British Columbia. All samples are analyzed by four acid digestion followed by both ICP-AES and ICP-MS for ultra-trace level detection for a multi-element suite with a 1% upper detection limit for base metals. Samples reporting over 1% for Zn and 1% for Pb are analyzed by assay grade four acid digestion and ICP-AES analysis with an upper detection limit of 30% and 20% respectively. Samples reporting Zn >30% and or Pb >20% are analyzed by traditional titration. Table 2: Composite 2019 Assay Results from Drilling and Resampling at the N204 Zone Hole NameZoneAreaFrom (m)To (m)Drilled Width (m)True Width (m)Zn (%)Pb (%)Pb + Zn (%)Current Drill Program N204-19-PP-001N204N20425.0033.008.008.001.080.441.52andN204N20447.0050.003.003.006.731.578.29N204-19-PP-002N204N20415.4016.901.501.501.690.382.07andN204N20420.6024.704.104.101.150.451.60andN204N20437.7044.006.306.301.660.362.03andN204N20449.0054.005.005.001.100.211.31N204-19-PP-003N204N20430.0032.002.002.005.701.537.23N204-19-PP-004N204N20443.4549.445.995.994.161.415.57andN204N20454.4456.442.002.001.940.292.23N204-19-PP-005N204N20436.0042.756.756.755.441.226.66andN204N20445.7552.006.256.251.520.361.88N204-19-PP-006N204N20420.5022.502.002.002.350.052.39andN204N20440.5047.166.666.663.070.873.95N204-19-PP-007N204N2049.0011.002.002.001.590.452.04andN204N20431.0037.006.006.002.890.623.51andN204N20445.0047.002.002.002.050.012.05N204-19-PP-008N204N2049.0012.003.003.001.030.071.10andN204N20416.0020.004.004.002.240.883.12andN204N20433.0042.009.009.005.782.087.86Relogging and Assay of Historical CoreN204-201*N204N20426.0030.904.904.900.860.351.21N204-324*N204N20410.5012.001.501.501.080.331.40andN204N20416.5021.505.005.001.970.522.49andN204N20433.2542.309.059.051.390.511.90N204-376*N204N20433.1037.604.504.506.791.868.66N204-426*N204N20434.8040.505.705.703.160.924.08N204-45**N204N2045.3011.706.406.400.870.151.02andN204N20433.7535.41.651.652.800.112.91N204-5*N204N20437.5044.46.906.901.680.792.47N204-062*N204N20411.9014.903.003.003.540.684.22andN204N20433.8035.802.002.002.600.783.37N204-11**N204N20418.1621.163.003.004.971.706.67andN204N20437.1639.162.002.001.210.381.59andN204N20451.4656.465.005.001.260.371.63N204-115*N204N20447.4048.401.001.000.890.111.00N204-160*N204N204No Significant Results N204-176*N204N20434.6037.803.203.202.881.083.96andN204N20447.2050.203.003.001.380.031.41N204-178*N204N204No Significant Results N204-208**N204N20414.2716.622.352.350.670.080.75N204-217*N204N204No Significant Results N204-234*N204N20439.0043.004.004.004.861.856.72N204-266*N204N20417.3019.302.002.001.360.351.71andN204N20442.3049.307.007.002.370.492.85N204-271*N204N204No Significant Results N204-348*N204N2049.7510.751.001.001.780.552.33andN204N20415.8517.001.151.152.410.913.32andN204N20433.8044.2010.4010.402.030.642.67N204-407*N204N20442.8047.104.304.301.340.902.24N204-64*N204N20443.9044.800.900.901.210.021.23N204-75**N204N2049.4011.402.002.002.380.392.77andN204N20452.4054.402.002.001.010.221.23N204-240*N204N20423.7826.983.203.200.690.240.93andN204N20435.0644.209.159.154.081.135.21 * Re-assay of historical core drilled by Cominco Ltd. ** Not previously assayed by Cominco Ltd. Table 3: Drill Hole Collar Locations (UTM NAD83 Zone 11) Hole NameZoneAreaEastingNorthingElevation (m)AzimuthDipDepth (m)N204-19-PP-001N204N204659150.46760912184.010-9060N204-19-PP-002N204N204659385.16760896182.380-9060N204-19-PP-003N204N2046596966760761178.510-9060N204-19-PP-004N204N204659404.96760587184.890-9060N204-19-PP-005N204N2046595946760617184.120-9060N204-19-PP-006N204N2046594756760377183.340-9060N204-19-PP-007N204N204660072.76760472176.020-9060N204-19-PP-008N204N204659651.96760907177.460-9060Historic Drill Hole CollarsN204-005N204N204660236.76760739174.930-9059.44N204-011N204N204660083.16760643175.880-9070.11N204-045N204N204659886.96760537176.910-9060.35N204-062N204N204659770.46760225177.460-9059.44N204-064N204N204659658.76760450178.850-9060.96N204-075N204N204659434.36760977179.950-9074.68N204-115N204N204659133.46760794184.630-9059.45N204-160N204N204659438.76760331183.030-9064.62N204-176N204N204659639.46760495180.130-9063.1N204-178N204N204659736.36760287177.420-9061.57N204-201N204N204658720.96760006188.950-9072.85N204-208N204N204659247.66760244185.340-9069.8N204-217N204N204659620.16760992177.540-9063.71N204-234N204N204659081.46759508183.870-9070.11N204-240N204N204660059.96760860175.530-9063.4N204-266N204N204659291.267608361840-9051.82N204-271N204N204659372.16761077180.920-9054.87N204-324N204N204659496.76760913178.850-9054.87N204-348N204N204659502.96760798181.620-9053.34N204-376N204N204659734.56760501178.030-9039.63N204-407N204N204659355.66760300184.690-9051.82N204-426N204N204659531.56760380181.580-9050.3 About Osisko Metals Osisko Metals Incorporated is a Canadian exploration and development company creating value in the base metal space with a focus on zinc mineral assets. The Company controls Canada’s two premier zinc mining camps. The Company’s flagship properties are: 1) the Pine Point Mining Camp (“PPMC”), located in the Northwest Territories, has an Inferred Mineral Resource of 38.4 Mt grading 4.58% zinc and 1.85% lead (6.58% ZnEq), making it the largest pit-constrained zinc deposit in Canada (please refer to the Amended Technical Report filed on SEDAR for further information). The PPMC is located on the south shore of Great Slave Lake in the Northwest Territories, near infrastructure and paved highway access and with 100 kilometres of haulage roads already in place. In 2019-2020, the company will explore for additional mineral resources and continue advancing the overall project. 2) The Bathurst Mining Camp (“BMC”), located in northern New Brunswick, has Indicated Mineral Resources of 1.96 Mt grading 5.77% zinc, 2.38% lead, 0.22% copper and 68.9g/t silver (9.00% ZnEq) and Inferred Mineral Resources of 3.85 Mt grading 5.34% zinc, 1.49% lead, 0.32% copper and 47.7 g/t silver (7.96% ZnEq) in the Key Anacon and Gilmour South deposits. In 2019-2020, the Company will continue to diligently develop and explore in order to confirm and grow both projects. The Company is also active in Quebec where it is advancing multiple base metal targets. The Mineral Resources mentioned in this press release conform to National Instrument 43-101 standards. These mineral resources were reported by the Company on December 6, 2018 and January 20, 2019 and were prepared by independent qualified persons, as defined by NI43 101 guidelines. The above-mentioned mineral resources are not mineral reserves as they do not have demonstrated economic viability. The quantity and grade of the reported Inferred Mineral Resources are conceptual in nature and are estimated based on limited geological evidence and sampling. Geological evidence is sufficient to imply but not verify geological grade and/or quality of continuity. Reference to historical production in this press release does not imply that any future mineral resources or discoveries will be of economic viability, nor does it imply that additional discoveries will be made. Zinc equivalency percentages are calculated using metal prices, forecasted metal recoveries, concentrate grades, transport costs, smelter payable metals and charges (see respective technical reports for details). For further information on Osisko Metals, visit or contact:Jeff Hussey President & CEO Osisko Metals Incorporated (514) 861-4441 Email: info@osiskometals.com Cautionary Note Regarding Forward-Looking Information This news release contains "forward-looking information" within the meaning of applicable Canadian securities legislation based on expectations, estimates and projections as at the date of this news release. Forward-looking information involves risks, uncertainties and other factors that could cause actual events, results, performance, prospects and opportunities to differ materially from those expressed or implied by such forward-looking information. Forward-looking information in this news release includes, but is not limited to, the use of proceeds of the Offering; the timing and ability of the Corporation, if at all, to obtain final approval of the Offering from the TSX Venture Exchange; an exemption being available under MI 61-101 and Policy 5.9 of the TSX Venture Exchange from the minority shareholder approval and valuation requirements for each related party transaction; objectives, goals or future plans; statements regarding exploration results and exploration plans. Factors that could cause actual results to differ materially from such forward-looking information include, but are not limited to, capital and operating costs varying significantly from estimates; the preliminary nature of metallurgical test results; delays in obtaining or failures to obtain required governmental, environmental or other project approvals; uncertainties relating to the availability and costs of financing needed in the future; changes in equity markets; inflation; fluctuations in commodity prices; delays in the development of projects; the other risks involved in the mineral exploration and development industry; and those risks set out in the Corporation's public documents filed on SEDAR at . Although the Corporation believes that the assumptions and factors used in preparing the forward-looking information in this news release are reasonable, undue reliance should not be placed on such information, which only applies as of the date of this news release, and no assurance can be given that such events will occur in the disclosed time frames or at all. The Corporation disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, other than as required by law. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein. A photo accompanying this announcement is available at

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