RHOJ

Last update 08 May 2025

Basic Info

Synonyms

ARHJ, FLJ14445, ras homolog family member J

+ [7]

Introduction

Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707).

100 Clinical Results associated with RHOJ

100 Translational Medicine associated with RHOJ

0 Patents (Medical) associated with RHOJ

157

Literatures (Medical) associated with RHOJ

01 Apr 2025·Orthopaedic Journal of Sports Medicine

The In Situ Force and Contribution of Each Ligamentous Band of the Deltoid Ligament in Ankle Joint Stability: A Cadaveric Biomechanical Study

Article

Author: Emori, Makoto ; Murahashi, Yasutaka ; Takahashi, Katsunori ; Shiwaku, Kousuke ; Kamiya, Tomoaki ; Teramoto, Atsushi ; Fujie, Hiromichi ; Watanabe, Kota

Background:Each band of the deltoid ligament cooperatively contributes to stability of the medial side of the ankle joint. Investigating the function of each band of the deltoid ligament is essential to assess abnormalities and develop treatment options.Purpose:To evaluate the changes in ankle kinematics when each band of the deltoid ligament is injured and to measure the in situ force of each ligamentous band in intact ankle kinematics.Study Design:Descriptive laboratory study.Methods:A total of 8 healthy fresh-frozen cadaveric legs were examined by applying forces through eversion and external rotation of the ankle joint using a 6 degrees of freedom robotic system. The deltoid ligament was separated into 6 discrete bands: tibionavicular ligament, tibiospring ligament, tibiocalcaneal ligament (TCL), anterior tibiotalar ligament, superficial posterior tibiotalar ligament (sPTTL), and deep posterior tibiotalar ligament; the bands were then sequentially transected. A loading test was performed in each model, and the changes in ankle motion and in situ force of each ligamentous band were measured using the robotic system.Results:When an eversion force was applied to the intact ankle, the in situ force of the sPTTL was 21.6 N in dorsiflexion and that of the TCL was 19.4 N in plantarflexion, both of which were significantly greater than those of the other ligamentous bands. Additionally, the amount of eversion under eversion loading increased significantly by 3.3° with sPTTL resection in dorsiflexion and by 4.2° with TCL resection in plantarflexion.Conclusion:The TCL and sPTTL play important roles among the ligamentous bands of the deltoid ligament. The sPTTL played a more significant role in ankle dorsiflexion, whereas the TCL played a more significant role in ankle plantarflexion.Clinical Relevance:The TCL and sPTTL should receive attention in the treatment of deltoid ligamentous injuries.

01 Dec 2024·Advanced Healthcare Materials

Letrozole‐Based Near‐Infrared Dynamic Imaging Targeting Ductal‐Vascular RhoJ From Pancreatic Intraepithelial Neoplasia to Pancreatic Ductal Adenocarcinoma

Article

Author: Ma, Xiaodong ; Wang, Lisheng ; Chen, Zilin ; Wang, Yishu ; Li, Ruihan ; Liu, Bei ; Hu, Weibin ; Zhao, Fengyun ; Tang, Shaohui ; Wang, Ping ; Hu, Zhuang ; Li, Fugui ; Li, Jingmin ; Cao, Zhi

AbstractPancreatic ductal adenocarcinoma (PDAC) relies heavily on neoangiogenesis for its progression, making early detection crucial. Here, LTZi‐MHI148 (Letrozole inhibitor bonding with MHI‐148 dye), a near‐infrared (NIR) fluorescent agent is developed, to target RhoJ (Ras Homolog Family Member J), a protein expressed in neonatal vasculature, for both imaging and therapy of early PDAC. This agent is synthesized by conjugating Letrozole with MHI‐148, exhibiting excellent NIR characteristics and photostability. In vitro studies showed that LTZi‐MHI148 selectively accumulated within pancreatic cancer cells through Organic Anion Transporting Polypeptide (OATP) transporters and bound to cytoplasmic RhoJ. In vivo, the probe effectively targeted neoangiogenesis and Pancreatic Intraepithelial Neoplasias (PanINs) in various PDAC models, including the orthotopic, ectopic, spontaneous, and tamoxifen‐induced tumors. Notably, LTZi‐MHI148 detected preneoplastic PanIN lesions with Overexpressed RhoJ and active neoangiogenesis in both spontaneous and tamoxifen‐induced PDAC murine models. Longitudinal imaging studies revealed that RhoJ‐targeted neoangiogenesis tracks lesion progression, highlighting LTZi‐MHI148's utility in monitoring disease progression. Furthermore, multiple LTZi‐MHI148 administrations attenuated PanINs to PDAC progression, suggesting its potential as a therapeutic intervention. These findings underscore the translational potential of LTZi‐MHI148 for the early detection and targeted therapy of PDAC, utilizing NIR‐I/II imaging to monitor RhoJ overexpression in precancerous ductal neoplasia associated with neoangiogenesis.

01 Nov 2024·Foot & Ankle International

Syndesmotic and Deltoid Injuries: Companions or Coincidences

Article

Author: Baumbach, Sebastian Felix ; Hesse, Nina ; Maßen, Felix ; Böcker, Wolfgang ; Gaube, Federico Paolo ; Polzer, Hans ; Saller, Maximilian Michael ; Reidler, Paul

Background: Syndesmotic complex injuries are supposedly associated with injuries to the deltoid ligament (DL) complex. Several syndesmosis classifications take DL injuries into account when rating the stability of the syndesmotic injury. Still, no study has yet assessed the frequency and severity of DL injuries in unstable syndesmotic injuries. The aim of this retrospective cohort study was to assess both the severity of the syndesmotic and DL injury in patients undergoing surgery for an unstable syndesmotic injury. Methods: The integrity of the syndesmotic and DL complex of 37 patients were assessed on MRI by 2 musculoskeletal radiologists. Eligible were adult patients with an acute, isolated, unstable syndesmotic injury (ligamentous or bony avulsions) who underwent surgery. The DL complex was classified as having 3 superficial (TNL/TSL/TCL) and 2 deep (aTTL/pTTL) components. Grade 0 indicated an intact ligament; grade I showed a periligamentous edema; grade II a partial tear presenting as laxity, irregular contour, or partial discontinuity with concomitant hyperintense signaling; grade III a complete tear; or grade IV in case of an avulsion fracture. Frequency and severity of DL injuries were assessed, and possible injury combinations analyzed using an h-cluster analysis and Mann-Whitney U test. Results: Mean severity (grade 0-3) was 2.6 ± 0.8 for the syndesmotic complex and 1.6 ± 1.1 for the DL (superficial 1.5 ± 1.1, deep 1.6 ± 1.1). Seven patients (19%) had no (n = 3; 8%) or minor (grade 1: n = 4; 11%) DL injuries. Overall, 2 different patient clusters and 4 separate ligament clusters were identified. Conclusion: Unstable syndesmotic injuries can occur isolated or with an accompanying DL injury. There appears to be a great heterogeneity between the severity of syndesmotic and deltoid ligament injuries.

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