catalase x Nrf2 x SOD x KEAP1

Last update 08 May 2025

Basic Info

Related Targets

catalaseNrf2SOD[+1]

100 Clinical Results associated with catalase x Nrf2 x SOD x KEAP1

100 Translational Medicine associated with catalase x Nrf2 x SOD x KEAP1

0 Patents (Medical) associated with catalase x Nrf2 x SOD x KEAP1

484

Literatures (Medical) associated with catalase x Nrf2 x SOD x KEAP1

01 Jun 2025·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Review

Author: Sahu, Mridul ; Jain, Utkarsh

Responses against infection trigger several signaling pathways that lead to the production of cytokines, these cytokines release ROS and RNS, damaging DNA and proteins turn into various diseases including cancer. To combat these harmful cytokines, the Nrf2 pathway is activated. The gene NFE2L2 encodes Nrf2, which is divided into seven conserved domains (Neh1-7). The DLG and ETGE motifs, conserved sequences of amino acid in the Neh2 domain of Nrf2, bind to the BTB domain of Keap1. BTB domain promotes Keap1's homodimerization resulting in Cul3 recruitment providing scaffold formation to E2 ubiquitin ligase to form ubiquitin complex. Under normal conditions, this complex regularly degrades Nrf2. However, once the cell is exposed to oxidative stress by ROS interaction with Keap1 resulting in conformational changes that stabilize the Nrf2. Nrf2 further concentrates on the nucleus where it binds with the transcriptional factor to perform the desired genes transcription for synthesizing SOD, GSH, CAT, and various other proteins which reduce the ROS levels preventing certain diseases. To prevent cells from oxidative stress, molecular hydrogen activates the Nrf2 pathway. To activate the Nrf2 pathway, molecular hydrogen oxidizes the iron porphyrin which acts as an electrophile and interacts with Keap1's cysteine residue.

01 May 2025·International Journal of Biological Macromolecules

Hybrid hydrolysates of soy protein and lactoferrin exerts synergistic antioxidant and anti-fatigue effect by modulating Keap1/Nrf2/HO-1 pathways

Article

Author: Qu, Haowen ; Liu, Ning ; Li, Meng ; Jiang, Nanyue ; Lu, Hongliang ; Zheng, Xiaoyan ; Fu, Zeshi ; Wang, Zhongjiang

Oxidative stress is an important cause of exercise fatigue formation. Nutritional intervention is an important way to modulate exercise fatigue. Lactoferrin (LF) and soybean protein (SP) are potential antioxidant bioactive components. Our findings demonstrate that SP-LF hybrid hydrolysates had effective 2,2-diphenylpicrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) radical scavenging activity and iron ion reducing ability. The synergistic effect between these hybrid hydrolysates were found to be superior to the single hydrolysate in terms of antioxidant level by the joint index analysis. These hybrid hydrolysates are characterized by high levels of amino acids with potential anti-fatigue effect: tyrosine (Tyr), phenylalanine (Phe), hydrophobic amino acid (HAAs) and branched-chain amino acids (BCAAs). In murine models, hybrid hydrolysates significantly prolonged weight-bearing swimming time, increased muscle/liver glycogen levels, decreased lactate, urea nitrogen, and malondialdehyde levels, and increased glutathione peroxidase, superoxide dismutase, catalase and ATPase activities. Pearson's correlation analysis established significant associations between antioxidant capacity and anti-fatigue efficacy. It alleviated fatigue through activating the Keap1/Nrf2/HO-1 signaling pathway, while increasing the expression levels of PGC-1α. These results collectively suggest that SP-LF hybrid hydrolysates demonstrate significant synergistic antioxidant and anti-fatigue activity and could be incorporated into functional foods as a dietary supplement to reduce fatigue.

01 May 2025·International Journal of Biological Macromolecules

An insight into nitrite-induced reproductive toxicity and the alleviation of injury by selenomethionine through activation of the Keap1/Nrf2 pathway in Procambarus clarkii

Article

Author: Zhu, Bao-Jian ; Sun, Xiao-Li ; Shi, Yan-Xia ; Tang, Bo-Ping ; Liu, Xin ; Zhang, Dai-Zhen ; Liu, Qiu-Ning ; Jiang, Jun-Jie ; Zhu, Xi-Rong ; Bian, Dan-Dan

Nitrite (NIT) is one of the most common toxic compounds in aquaculture. However, the effects of NIT exposure on the reproductive capabilities of aquatic animals remain largely unknown. This study explored the consequences of NIT exposure on the ovarian tissues of Procambarus clarkii and revealed that it significantly reduced ATP content and gonadosomatic index (GSI), causing metabolic imbalance, reactive oxygen species (ROS) accumulation, increased oxidative stress, and altered antioxidant enzyme activity. Pathological investigation revealed a decrease in the number of oogonia and oocytes, as well as an increase in vacuolated and apoptotic cells in the ovary. Differentially expressed genes (DEGs) and gene set enrichment analysis (GSEA) revealed that genes related to oxidative stress, apoptosis, and autophagy were significantly upregulated, whereas genes involved in ovarian development and energy metabolism were downregulated. These findings suggested that NIT exposure not only caused oxidative stress and abnormal energy metabolism, but also activated autophagy and apoptosis in the ovarian cells. In addition, the Nrf2/Keap1 (nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1) signaling pathway was found to be activated. Nrf2 knockdown inhibited antioxidant, apoptotic, and autophagy activities while increasing the expression of genes related to reproduction and nutrient metabolism. Selenomethionine (Se-Met) treatment alleviated NIT exposure-induced ovarian damage by elevating antioxidant capacity, superoxide dismutase, and catalase activities and reducing the levels of H₂O₂, malondialdehyde, glutathione, and ROS. In addition, Se-Met improved the anti-inflammatory and antioxidant stress responses by activating the Nrf2/Keap1 pathway and attenuating NIT-induced ovarian toxicity. Overall, this study provides a novel approach for maintaining ovarian homeostasis after NIT exposure.

Analysis

Perform a panoramic analysis of this field.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis