FAU

Last update 08 May 2025

Basic Info

Synonyms

40S ribosomal protein S30, asr1, FAU

+ [10]

Introduction

May have pro-apoptotic activity. Component of the 40S subunit of the ribosome. Contributes to the assembly and function of 40S ribosomal subunits.

100 Clinical Results associated with FAU

100 Translational Medicine associated with FAU

0 Patents (Medical) associated with FAU

262

Literatures (Medical) associated with FAU

01 Apr 2025·Nature Structural & Molecular Biology

Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough

Article

Author: Čapková Pavlíková, Zuzana ; Miletínová, Petra ; Beznosková, Petra ; Becker, Thomas ; Durante, Ignacio M ; Paris, Zdeněk ; Pospíšilová, Klára ; Valášek, Leoš Shivaya ; Roithová, Adriana ; Lukeš, Julius ; Záhonová, Kristína ; Kachale, Ambar

Transfer RNAs (tRNAs) serve as a dictionary for the ribosome translating the genetic message from mRNA into a polypeptide chain. In addition to this canonical role, tRNAs are involved in other processes such as programmed stop codon readthrough (SC-RT). There, tRNAs with near-cognate anticodons to stop codons must outcompete release factors and incorporate into the ribosomal decoding center to prevent termination and allow translation to continue. However, not all near-cognate tRNAs promote efficient SC-RT. Here, with the help of Saccharomyces cerevisiae and Trypanosoma brucei, we demonstrate that those tRNAs that promote efficient SC-RT establish critical contacts between their anticodon stem (AS) and ribosomal proteins Rps30/eS30 and Rps25/eS25 forming the decoding site. Unexpectedly, the length and well-defined nature of the AS determine the strength of these contacts, which is reflected in organisms with reassigned stop codons. These findings open an unexplored direction in tRNA biology that should facilitate the design of artificial tRNAs with specifically altered decoding abilities.

01 Feb 2025·Cell and Tissue Research

Single cell transcriptomics profiling of the stromal cells in the pathologic association of ribosomal proteins in the ischemic myocardium and epicardial fat

Article

Author: Teramoto, Darren ; Cha, Ed ; Sedighim, Sharona ; Keklikian, Angelo ; Fung, Cameron ; Doescher, Christian ; La, Vy ; Thai, An ; Cheng, Pauline ; Thankam, Finosh G ; Kamal, Nawfal

AbstractSustenance of ischemia in the surviving cardiac tissue following myocardial infarction (MI) elicits a proinflammatory milieu resulting in subsequent pathological episodes. Also, the activation and release of ribosomal proteins under ischemic insults have been unveiled; however, their extra ribosomal functions are unknown. We identified the ribosomal proteins including RPL10A, RPL14, RPL30, RPS18, FAU-40 (RPS30), and RPSA (Laminin Receptor, LR) in the vesicles of ischemia challenged epicardial adipose tissue derived stromal cells (EATDS). The present study aimed to assess the association of these proteins in the epicardial adipose tissues (EAT) and left ventricular (LV) myocardium and isolated stromal cells (EATDS and LVSCs) from hyperlipidemic (HL), MI and coronary artery bypass graft (CABG) swine models. The findings revealed an upregulation of RPL10A, RPL14, RPL30, RPS18, RPS30, and RPSA in the LV tissues of CABG and HL swine with a concomitant reduction in the MI group. RPS30 displayed similar upregulation in EAT, whereas the expression of other ribosomal proteins was not significantly altered. Additionally, the ischemic LVSCs and EATDS displayed altered expression status of these genes compared to the control. Also, the RPS18 + , RPL30 + and RPSA + LVSCs favored ischemia and revealed similar anti-inflammatory and regenerative sub-phenotypes reflecting the protective/survival mechanisms. Further understanding regarding the underlying molecular mechanisms and functions of these ribosomal proteins offers immense translational opportunities in the better management of ischemic cardiac complications.

01 Jan 2025·Carbohydrate Polymers

β-Glucan content increase in Waxy-mutated barley is closely associated with positive stress responses and is regulated by ASR1

Article

Author: Li, Qiao ; Li, Zhongyi ; Zhang, Zhihui ; Pan, Zhifen ; Zeng, Xingquan ; Cai, Jingchi ; Tang, Hongmei

Mixed-linkage (1,3; 1,4)-β-D-glucan (MLG) impacts the food and industrial end-uses of barley, but the molecular mechanism of variations in MLG content remains unclear. MLG content usually increases in Waxy-mutated barley. This study applied transcriptomic, proteomic, and metabolomic analyses to Waxy-mutated recombinant inbred lines with higher MLG content and wild-type lines with lower MLG content, and identified candidate genes and pathways regulating MLG content through combining preliminary gene function analysis. MLG biosynthesis differed significantly during late grain development in the Waxy-mutated and wild-type barley lines. The MLG increase was closely associated with strongly active sugar and starch metabolism and stress-responsive plant hormones, particularly abscisic acid (ABA) signaling process. Stress-responsive transcript factors ILR3, BTF3, RGGA, and PR13 protein bind to CslF6, which is critical for barley MLG biosynthesis, and the stress-responsive gene ASR1 also had a positive effect on MLG increase. Waxy mutation enhances barley stress responses by activating ABA- or other stress-responsive plant hormones signaling processes, which facilitates MLG biosynthesis. This study provides a new approach for elucidating the variations in MLG content of barley grains.

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