Last update 01 Nov 2024

SRF

Last update 01 Nov 2024

Basic Info

Synonyms

MCM1, serum response factor, SRF

Introduction

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.

Drugs associated with SRF

CCG-232964

Target

MRTFB x RP4 x SRF

Mechanism

MRTFB inhibitors [+2]

Active Org.

University of Michigan

Originator Org.

University of Michigan

Active Indication

Scleroderma, Systemic

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CCG-203971

Target

MRTFA x SRF

Mechanism

MRTFA inhibitors [+1]

Active Org.

Genesis Biosciences LLC [+3]

Originator Org.

Genesis Biosciences LLC

Active Indication

Glaucoma, Open-Angle [+1]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SRF

100 Translational Medicine associated with SRF

0 Patents (Medical) associated with SRF

3,591

Literatures (Medical) associated with SRF

01 Jan 2025·Biomaterials Advances

Iron-based magnetic nanocomplexes for combined chemodynamic and photothermal cancer therapy through enhanced ferroptosis

Article

Author: Dai, Honglian ; Wei, Wenying ; Yang, Junwei ; Wang, Ziqi ; Yin, Meizhen ; Lian, Chenxi ; Liu, Jiawei ; Xu, Zhangmancang ; Lin, Jinwei ; Kang, Haifei

Chemodynamic therapy (CDT) guided by Fenton chemistry and iron-containing materials can induce ferroptosis as a prospective cancer treatment method, but the inefficient Fe³⁺/Fe²⁺ conversion restricts the monotherapeutic performances. Here, an iron-based nanoplatform (Fe₃O₄-SRF@FeTA) including a magnetic core and a reductive film is developed for combined CDT and photothermal therapy (PTT) through ferroptosis augmentation. The inner iron oxide core serves as a photothermal transducer, a magnet-responsive module, and an iron reservoir for CDT. The coated Fe³⁺-tannic acid film (FeTA) provides extra iron and reductants for Fe³⁺/Fe²⁺ conversion acceleration, and functions as a door keeper for the pH- and light-responsive release of the embedded ferroptosis inducer sorafenib (SRF). The in vitro results demonstrate that the iron-based nanocomplexes promote the production of lipid peroxide through the amplified Fenton activity, and downregulate glutathione involved in lipid peroxide repair system through the responsively released SRF. Upon accumulation in tumor by magnetic targeting and sequential laser irradiation locoregionally, Fe₃O₄-SRF@FeTA nanocomplexes present prominent in vivo anticancer efficacy by leveraging PTT and CDT-enhanced ferroptosis.

01 Dec 2024·Journal of Hazardous Materials

Differential inhibition of tire wear particles on sludge dewatering by aging modes

Article

Author: Li, Kun ; Ye, Zidong ; Hao, Wanqi ; Chen, Zhangle

The study assessed the acute toxicities of tire wear particles (TWPs) on activated sludge, comparing cryogenically ground TWPs (C-TWPs) with photo-aged (PA-TWPs), ozone-aged (OA-TWPs), and Fenton-aged (FA-TWPs) variants over 96 h. At 0.1 mg/L, TWPs showed no significant effects on sludge respiration or purification. However, at 50 mg/L, significant impacts on respiration, decontamination capacity, and microbial community structure were observed, particularly in aged TWPs. Specifically, aged TWPs, especially FA-TWPs, are prone to inducing necrosis by generating non-cellular reactive oxygen species (ROS) catalyzed by persistent free radicals, leading to an increase in lactate dehydrogenase release ranging from 215 % to 284 %. Conversely, C-TWPs tend to trigger apoptosis via intracellular ROS accumulation, leading to a 358 % increase in intracellular ROS. Aged TWPs exhibited higher affinities for proteins and polysaccharides, while C-TWPs preferred phospholipids. All TWPs adversely affected sludge dewatering, with strong correlations found between specific resistance to filtration (SRF) and total protein (r = 0.981, p < 0.001) and between bound water and early cell apoptosis (r = 0.961, p < 0.01). Additionally, a correlation between SRF and cellular necrosis (r = 0.956, p < 0.01) was noted, linked to increased protein and extracellular polymeric substance levels. These results emphasize substantial influence of aged TWPs on sludge dewatering efficiency via diverse bacterial cell death mechanisms.

01 Dec 2024·Molecular Biology Reports

Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture

Article

Author: Cross, Bethany ; Cook, Isabel ; Neidviecky, Emma ; Carlson, Jennifer ; Deng, Huai

BACKGROUNDThe Keap1-Nrf2 pathway serves as a central regulator that mediates transcriptional responses to xenobiotic and oxidative stimuli. Recent studies have shown that Keap1 and Nrf2 can regulate transcripts beyond antioxidant and detoxifying genes, yet the underlying mechanisms remain unclear. Our research has uncovered that Drosophila Keap1 (dKeap1) and Nrf2 (CncC) proteins can control high-order chromatin structure, including heterochromatin.METHODS AND RESULTSIn this study, we identified the molecular interaction between dKeap1 and lamin Dm0, the Drosophila B-type lamin responsible for the architecture of nuclear lamina and chromatin. Ectopic expression of dKeap1 led to an ectopic localization of lamin to the intra-nuclear area, corelated with the spreading of the heterochromatin marker H3K9me2 into euchromatin regions. Additionally, mis-regulated dKeap1 disrupted the morphology of the nuclear lamina. Knocking down of dKeap1 partially rescued the lethality induced by lamin overexpression, suggesting their genetic interaction during development.CONCLUSIONSThe discovered dKeap1-lamin interaction suggests a novel role for the Keap1 oxidative/xenobiotic response factor in regulating chromatin architecture.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

SRF

Basic Info

Related

Analysis