HSP90AA2P

Last update 08 May 2025

Basic Info

Synonyms

Heat shock 90 kDa protein 1 alpha-like 3, heat shock protein 90 alpha family class A member 2, pseudogene, Heat shock protein HSP 90-alpha A2

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Introduction

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

100 Clinical Results associated with HSP90AA2P

100 Translational Medicine associated with HSP90AA2P

0 Patents (Medical) associated with HSP90AA2P

141

Literatures (Medical) associated with HSP90AA2P

02 May 2024·Oncogene

Correction: Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression

Author: Jayaprakash, P ; Guo, J ; Ying, Q ; Woodley, D T ; Situ, A J ; Tsen, F ; O'Brien, K ; Sahu, D ; Bhatia, A ; Zou, M ; Ulmer, T S ; Dong, H ; Schmidt, T ; Li, W ; Tong, C ; Chen, M ; Hou, Y

12 Dec 2023·Annals of Medicine

RETRACTED ARTICLE: A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma

Review

Author: Jiang, Li-hong ; Wang, Yi-qiang ; Pang, Bing-yao ; Wang, Xiaoli ; Leng, Yan

BACKGROUNDHepatocellular carcinoma lacks ideal diagnostic biomarkers. There is a lack of scientific evaluation of relevant promising biomarkers as well. Therefore this study reanalyzes the related studies of 11 blood biomarkers of HCC, and compares the diagnostic value of these biomarkers for HCC systematically.METHODSThe relevant literatures on the diagnostic value in HCC of 11 blood indexes in recent 5 years were searched in PubMed, Embase, and Cochrane libraries. Data were extracted and analyzed.RESULTSFinally, 83 literature studies were brought into meta-analysis. The pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The AUC and sum of sensitivity and specificity of the combination of AFP and other biomarkers were all significantly higher than that of AFP, including AFP + AFP-L3 + DCP, AFP + DCP, AFP/DCP, AFP + GPC3. Among other biomarkers, the AUC and sum of sensitivity and specificity of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN were significantly higher than that of AFP. In this study, GP73 had the highest sum of sensitivity and specificity (1.78) and AUC (0.95).CONCLUSIONSThe pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The combination of AFP and other biomarkers improved the diagnostic efficiency. The diagnostic value of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN was higher than that of AFP. GP73 had the best diagnostic value for HCC with the highest sum of sensitivity and specificity (1.78) and AUC (0.95).KEY MESSAGESThe pooled sensitivity and specificity of AFP were 0.61 and 0.87, respectively. The AUC of AFP were 0.78. The combination of AFP and other biomarkers improved the diagnostic efficiency of HCC.The diagnostic value of biomarkers including DCP, GPC3, GP73, Hsp90alpha, midkine, and OPN was higher than that of AFP.GP73 had the best diagnostic value for HCC.

01 Dec 2023·Marine Biotechnology

Muscle Transcriptome Sequencing Revealed Thermal Stress–Responsive Regulatory Genes in Farmed Rohu, Labeo rohita (Hamilton, 1822)

Article

Author: Kumar, Pokanti Vinay ; Reang, Dhalongsaih ; Rajeshkannan, R ; Bhendarkar, Mukesh P ; Rasal, Kiran D ; Krishnani, Kishore K ; Sonwane, Arvind A ; Dey, Diganta ; Brahmane, Manoj P ; Nagpure, Naresh S ; Pawar, Sachin S ; Acharya, Arpit ; Kurade, Nitin P

Rohu, Labeo rohita, is one of the most important aquaculture species in the Indian subcontinent. Understanding the molecular-level physiological responses to thermal stress or climate change is essential. In the present work, transcriptome sequencing was carried out in the muscle tissue of the rohu in response to heat stress (35 °C) in comparison with the control (28 °C). A total of 125 Gb of sequence data was generated, and the raw-reads were filtered and trimmed, which resulted in 484 million quality reads. Reference-based assembly of reads was performed using L. rohita genome, and a total of 90.17% of reads were successfully mapped. A total of 37,462 contigs were assembled with an N50 value of 1854. The differential expression analysis revealed a total of 107 differentially expressed genes (DEGs) (15 up-, 37 down-, and 55 neutrally regulated) as compared to the control group (Log2FC > 2, P < 0.05). Gene enrichment analysis of DEGs indicates that transcripts were associated with molecular, biological, and cellular activities. The randomly selected differentially expressed transcripts were validated by RT-qPCR and found consistent expression patterns in line with the RNA-seq data. Several transcripts such as SERPINE1(HSP47), HSP70, HSP90alpha, Rano class II histocompatibility A beta, PGC-1 and ERR-induced regulator, proto-oncogene c-Fos, myozenin2, alpha-crystallin B chain-like protein, angiopoietin-like protein 8, and acetyl-CoA carboxylases have been identified in muscle tissue of rohu that are associated with stress/immunity. This study identified the key biomarker SERPINE1 (HSP47), which showed significant upregulation (~ 2- to threefold) in muscle tissue of rohu exposed to high temperature. This study can pave a path for the identification of stress-responsive biomarkers linked with thermal adaptations in the farmed carps.

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HSP90AA2P

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