SSTR1

LOS ANGELES, Oct. 26, 2022 /PRNewswire/ -- The Prostate Cancer Foundation (PCF) today announced the Class of 2022 Young Investigator Award recipients totaling $7.2 million in funding for innovative prostate cancer research. PCF Young Investigator Awards are intended to identify a cohort of future research leaders who will keep the field of prostate cancer research vibrant with new ideas and offer career and project support for early career physicians and scientists who are committed to advancing the prostate cancer field. Thirty-four PCF Young Investigator Awards totaling $7.2 million were granted to the promising next generation of cancer researchers. PCF Young Investigator Awards – Class of 2022 2022 Todd Boehly-PCF Young Investigator Award Principal Investigator: Vipul Bhatia, PhD, Fred Hutchinson Cancer Center Mentors: John K. Lee, MD, PhD; Peter Nelson, MD Project Title: Development of Next-Generation STEAP1 Chimeric Antigen Receptor T Cell Therapies to Combat Antigen Escape and T Cell Dysfunction 2022 CRIS Cancer Foundation, Eustace Wolfington and Larry Leeds-PCF Young Investigator Award Principal Investigator: Dimitrios Doultsinos, PhD, University of Oxford Mentors: Claire Fletcher, PhD; Ian Mills, PhD Project Title: Exploring Synthetic Lethality of Targeting miR346-Unfolded Protein Response Dependent DNA Damage Response Mechanisms in Treatment-Resistant Prostate Cancer 2022 Michael & Lori Milken-PCF Young Investigator Award Principal Investigator: Renu Eapen, MBBS, FRACS (Urology), Peter MacCallum Cancer Center Mentors: Michael Hofman, MBBS; Declan Murphy, MC, BCh, BaO, FRCS Urol, FRACS; Paul Neeson, PhD Project Title: The Clinical and Immune Landscape Changes in Response to Upfront Lutetium PSMA Therapy in Patients with High-Risk Localized Prostate Cancer 2022 Foundation Medicine-PCF Young Investigator Award Principal Investigator: Nicolette Fonseca, PhD , University of British Columbia Mentors: Alexander Wyatt, D.Phil; Kim Chi, MD Project Title: Developing a Novel ctDNA-Based Approach to Patient Risk Stratification and Treatment Selection in mCRPC: A Large Population-Based Cohort Study 2022 ZERO, John & Amy Phelan, and Alec & Kelly Gores-PCF VAlor Young Investigator Award Principal Investigator: Jun Gong, MD, Cedars-Sinai Medical Center Mentors: Stephen Freedland, MD; Edwin Posadas, MD Project Title: A Nationwide VA Study on Systemic Treatment Patterns in Black Patients with Metastatic Castration-Resistant Prostate Cancer 2022 Todd Boehly-PCF Young Investigator Award Principal Investigator: Roni Haas, PhD, University of California, Los Angeles Mentor: Paul Boutros, PhD, MBA Project Title: Associating Germline Variants with Prostate Tumour Evolution and Lethality 2022 Ronald & Victoria Simms-PCF Young Investigator Award Principal Investigator: Ashley E. Holly, PhD, MBA, Cleveland Clinic Mentors: Nima Sharifi, MD; Matthew Vander Heiden, MD, PhD Project Title: Elucidating Metabolic Health for Prostate Cancer Patients through Dietary Intervention (DINE Study) 2022 James Coulter-PCF Young Investigator Award Principal Investigator: Tamara Jamaspishvili, MD, PhD, State University of New York Upstate Medical University Mentors: Jeremy Squire, PhD; Alina Basnet, MD Project Title: Single-Center Retrospective Clinical Study of Artificial Intelligence (AI)-Based Protein Assessment of Three Tumor Suppressor Genes ("Triple-TSG") for Improved Risk Stratification and Treatment Management of Advanced Prostate Cancer 2022 Michael & Lori Milken-PCF Young Investigator Award Principal Investigator: Mayuko Kanayama, MD, PhD, Johns Hopkins University Mentors: Jun Luo, PhD; Tamara Lotan, MD; William Isaacs, PhD Project Title: Functional and Treatment Implications of a Rare Germline HOXB13 Variant Affecting Risk of Lethal Prostate Cancer in Patients of African Ancestry 2022 Wild Dunes MGA-PCF Young Investigator Award Principal Investigator: Dong-Woo Kang, PhD, Harvard: Dana-Farber Cancer Institute Mentors: Christina Dieli-Conwright, PhD, MPH; Alicia Morgans, MD, MPH; Timothy Rebbeck, PhD Project Title: Exercise for Tumor Suppressive Impact in Black Patients with Prostate Cancer on Active Surveillance: The RE-MOVE Trial 2022 Henry M. Jackson Foundation for the Advancement of Military Medicine-PCF Young Investigator Award Principal Investigator: Indu Kohaar, PhD, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences; Henry M. Jackson Foundation for the Advancement of Military Medicine Mentors: Gyorgy Petrovics, PhD; William Douglas Figg Sr., PharmD Project Title: Genetic Determinants of Aggressive Prostate Cancer in African American Patients 2022 Tony & Sage Robbins-PCF Young Investigator Award Principal Investigator: Weiping Li, PhD, Columbia University Medical Center Mentors: Michael Shen, PhD; Christopher Barbieri, MD, PhD; Alberto Ciccia, PhD Project Title: Investigating the Role of Androgen Signaling in Promoting Genomic Instability in Prostate Cancer 2022 Ronald & Victoria Simms-PCF Valor Young Investigator Award Principal Investigator: Neil Lin, PhD, University of California, Los Angeles (UCLA) Mentors: Andrew Goldstein, PhD; Matthew Rettig, MD; Isla Garraway, MD, PhD Project Title: Using a Novel 3D Platform to Develop Metabolism-based Prostate Cancer Therapies 2022 Eustace Wolfington-PCF Young Investigator Award Principal Investigator: Jacob Orme, MD, PhD, Mayo Clinic Mentors: Alan Bryce, MD; Sean Park, MD, PhD; Haojie Huang, PhD Project Title: Overcoming NRG-1-Mediated Resistance in CRPC 2022 Robert Kraft, Adam Cohn, and Igor Tulchinsky-PCF Young Investigator Award Principal Investigator: Ryan Park, MD, Harvard: Massachusetts General Hospital Mentors: Nir Hacohen, PhD; Anthony D'Amico, MD, PhD Project Title: Modulating T cell State to Prevent Radiation-Induced Lymphopenia and Enhance Anti-Tumor Immunity 2022 Joel Holsinger-PCF Young Investigator Award Principal Investigator: Sagar Patel, MD, Winship Cancer Institute of Emory University Mentors: Martin Sanda, MD; Ashesh Jani, MD; Arthur Stillman, MD, PhD Project Title: Biomarker-Based Approaches to Understand and Predict Cardiovascular Toxicity from Androgen Deprivation Therapy in Patients with Prostate Cancer 2022 National Cancer Institute-PCF Young Investigator Award Principal Investigator: Michael Rothberg, MD, National Cancer Institute (NCI) Mentors: Peter Pinto, MD; Adam Sowalsky, PhD Project Title: Identifying Tumor Microenvironmental Factors Associated with Oncologic Response to Irreversible Electroporation Focal Therapy for Prostate Cancer 2022 John Black Charitable Foundation-PCF Young Investigator Award Principal Investigator: Ashwin Sachdeva, MBBS, PhD, University of Manchester Mentors: Noel Clarke, ChM; Nicholas James, PhD, MBBS; Gerhardt Attard, PhD, MBBS Project Title: Mitigating Toxicity of Novel AR-Targeted Therapies in Advanced Prostate Cancer 2022 Steve & Andrea Wynn-PCF Young Investigator Award Principal Investigator: David Sanin, PhD, Johns Hopkins University Mentors: Samuel Denmeade, MD; Edward Pearce, PhD Project Title: Expanded Myeloid-Derived Suppressor Cells Underpin Resistance to Bipolar Androgen Therapy in Patients with Advanced Prostate Cancer 2022 Igor Tulchinsky, Robert Taubman and Richard Sandler-PCF VAlor Young Investigator Award Principal Investigator: Martin Schoen, MD, MPH, Saint Louis Veterans Affairs Medical Center Mentors: Kristen Sanfilippo, MD, MPH; Bruce Montgomery, MD; Ruth Etzioni, PhD Project Title: Outcomes of Metastatic Hormone Sensitive Prostate Cancer in Veterans: Facilitating Personalized Medicine 2022 Michael & Tricia Berns-PCF Young Investigator Award Principal Investigator: Laura Sena, MD, PhD , Johns Hopkins University Mentors: Samuel Denmeade, MD; Erika Pearce, PhD Project Title: Understanding Metabolic Differentiation of Prostate Cancer by Bipolar Androgen Therapy 2022 Point Biopharma-PCF VAlor Young Investigator Award Principal Investigator: Marina Sharifi, MD, PhD , University of Wisconsin Mentors: Joshua Lang, MD; Shuang Zhao, MD, MSc; Brett Carver, MD Project Title: Interrogating the Intersection of PSMA and PI3K Pathway Signaling as a Novel Combination Approach in Treatment Resistant Prostate Cancer 2022 Todd Boehly-PCF Young Investigator Award Principal Investigator: Raunak Shrestha, PhD, University of California, San Francisco Mentors: Felix Feng, MD; David Quigley, PhD Project Title: Investigating Chromatin Reprogramming to Overcome Treatment Resistance in Advanced Prostate Cancer 2022 John Tyson-PCF Young Investigator Award Principal Investigator: Bilal A. Siddiqui, MD, The University of Texas MD Anderson Cancer Center Mentors: Christopher Logothethis, MD; Sumit Subudhi, MD, PhD Project Title: Bispecific Immunotherapy Strategies to Overcome the Immunosuppressive Prostate Tumor Microenvironment 2022 Sage & Tony Minella-PCF Young Investigator Award Principal Investigator: Woogwang Sim, PhD, University of California, San Francisco Mentor: Rohit Bose, MD, PhD Project Title: PTEN/P53 Altered Prostate Cancer has Unique Role for Tumor Associated Macrophages upon Apalutamide Resistance 2022 Nelson & Claudia Peltz-PCF Young Investigator Award Principal Investigator: Udit Singhal, MD, University of Michigan Mentors: Todd Morgan, MD; Felix Feng, MD; Daniel Lin, MD Project Title: Leveraging Artificial Intelligence for Optimization of Active Surveillance and Genetic Testing in Patients with Localized Prostate Cancer 2022 John & Daria Barry-PCF VAlor Young Investigator Award Principal Investigator: Alexandra Sokolova, MD, Oregon Health & Science University Mentors: Bruce Montgomery, MD; Heather Cheng, MD, PhD Project Title: Cascade Genetic Testing in Prostate Cancer: Evaluating and Overcoming Barriers 2022 John Black Charitable Foundation-PCF Young Investigator Award Principal Investigator: Vasilis Stavrinides, MD, PhD, University College London Mentors: Mark Emberton, MD; Emek Demir, PhD Project Title: Immune Topology as a Predictor of Prostate Cancer Outcome in Imaging-Based Cohorts 2022 Ms. Lucy Shostak & Dr. Elliot Abramowitz-PCF Young Investigator Award Principal Investigator: William Storck, PhD, University of Michigan Rogel Cancer Center Mentor: Joshi Alumkal, MD Project Title: Development of a Rational Co-Targeting Approach to Block Neuroendocrine Prostate Cancer Cell Survival 2022 CRIS Cancer Foundation and Clay Hamlin-PCF Young Investigator Award Principal Investigator: Alexander Wurzer, PhD, Technical University of Munich Mentor: Matthias Eiber, MD Project Title: Investigating Radiohybrid PSMA-Ligands for Targeted Alpha Therapy, with the Aim to Improve Targeted Alpha Therapy of Metastatic Castration-Resistant Prostate Cancer 2022 Silas Chou-PCF Young Investigator Award Principal Investigator: Lanbo Xiao, PhD , University of Michigan Mentor: Arul Chinnaiyan, MD, PhD Project Title: Targeting SWI/SNF Chromatin Remodeling Complex to Combat Castrate-Resistant Prostate Cancer 2022 John Miller-PCF Young Investigator Award Principal Investigator: Young Yoo, PhD, Northwestern University Mentors: Sarki Abdulkadir, MD, PhD; Navdeep Chandel, PhD Project Title: Targeting Metabolic Adaptation to Treat TP53-mutated Lethal Prostate Cancer 2022 Ms. Lucy Shostak-PCF Young Investigator Award Principal Investigator: Xiaolin Zhu, MD, PhD , University of California, San Francisco Mentors: Felix Feng, MD; Rahul Aggarwal, MD; David Quigley, PhD Project Title: Investigating SSTR1 as a Novel Therapeutic Target for Acquired Resistance to Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer 2022 William C. & Gina B. Carithers-PCF Young Investigator Award Principal Investigator: Nicholas Zorko, MD, PhD, University of Minnesota / Masonic Cancer Center Mentors: Jeffrey Miller, MD; Emmanuel Antonarakis, MD; Martin Felices, PhD Project Title: Multiplex Engineered CAR iNK Cells Targeting B7-H3 to Treat Metastatic Castration Resistant Prostate Cancers About the Prostate Cancer Foundation The Prostate Cancer Foundation (PCF) is the world's leading philanthropic organization dedicated to funding life-saving prostate cancer research. Founded in 1993 by Mike Milken, PCF has been responsible for raising close to $1 billion in support of cutting-edge research by more than 2,200 research projects at 245 leading cancer centers in 28 countries around the world. Since PCF's inception, and through its efforts, patients around the world are living longer, suffering fewer complications, and enjoying better quality of life. PCF is committed to creating a global public square for prostate cancer, in service to our mission of ending death and suffering from the disease. Learn more at pcf.org. MEDIA CONTACT: Staci L. Vernick Prostate Cancer Foundation [email protected] [email protected] 610-812-6092 SOURCE Prostate Cancer Foundation