MAP4K3

Last update 08 May 2025

Basic Info

Synonyms

Germinal center kinase-related protein kinase, GLK, MAP4K3

+ [6]

Introduction

Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443).

100 Clinical Results associated with MAP4K3

100 Translational Medicine associated with MAP4K3

0 Patents (Medical) associated with MAP4K3

349

Literatures (Medical) associated with MAP4K3

01 May 2025·Theoretical and Applied Genetics

A Golden2-like transcription factor regulates Brassica napus seed vigor after artificial aging

Article

Author: Ye, Qianjun ; Ping, Xiaoke ; Yan, Mei ; Chen, Sheng ; Li, Jiana ; Zhang, Taiyuan ; Liu, Liezhao ; Wang, Jia ; Hu, Xiaojie

KEY MESSAGEA novel GLK transcription factor, BnaA03.G2-like, regulates seed vigor after aging by affecting FAs composition in B. napus. Seeds, a most crucial materials for crop production, constitute the basis of agriculture. Seed aging usually occurs during storage, especially for seeds with high oil content. However, the genes and mechanisms underlying seed aging in Brassica napus, a widely grown oilseed crop, remain largely unexplored. In this study, nine SNPs associated with seed vigor after aging were identified through a genome-wide association study, and transgenic seeds confirmed that BnaA03.G2-like negatively regulated seed vigor after aging. Haplotype and gene-based association analyses revealed that S_A3.16900957 and S_A3.16901008 were two core variants located within BnaA03.G2-like. Transcriptome analysis and gas chromatography results suggested that BnaA03.G2-like regulated fatty acid biosynthesis, and the linoleic acid content significantly increased in the seeds of BnaA03.G2-like overexpression lines but decreased in the seeds of BnaA03.G2-like RNA interference lines. Further correlation analysis and malondialdehyde determination revealed that BnaA03.G2-like regulated seed vigor by affecting the linoleic acid content in mature seeds and the degree of membrane lipid peroxidation during seed aging. This study initially reported the function of BnaA03.G2-like and its favorable alleles, providing genetic resources for seed antiaging breeding in B. napus.

01 Apr 2025·New Phytologist

GLKs directly regulate carotenoid biosynthesis via interacting with GBFs in plants

Article

Author: Lui, Andy ; Mazourek, Michael ; Giovannoni, James G. ; Li, Li ; Zhao, Yunde ; Sun, Tianhu ; Hazra, Abhijit ; Zeng, Shaohua ; Owens, Lauren A. ; Rao, Sombir ; Fei, Zhangjun ; Wang, Xin

Summary

Carotenoids are vital photosynthetic pigments for plants. Golden2‐like transcription factors (GLKs) are widely recognized as major regulators of Chl biosynthesis and chloroplast development. However, despite GLKs being subjected to intensive investigations, whether GLKs directly regulate carotenoid biosynthesis and the molecular mechanisms by which GLKs transcriptionally activate their target genes remain unclear.

Here, we report that GLKs directly regulate carotenoid biosynthesis and activate their target genes in a G‐box binding factor (GBF)‐dependent manner in Arabidopsis.

Both in vitro and in vivo studies reveal that GLKs physically interact with GBFs to activate transcription of phytoene synthase (PSY), the gene encoding a rate‐limiting enzyme for carotenoid biosynthesis. While GLKs possess transactivation activity, they depend on GBFs to directly bind to the G‐box motif to modulate PSY expression. Loss of GBFs impairs GLK function in regulating carotenoid and Chl biosynthesis. Since the G‐box motif is an enriched motif in the promoters of GLK‐regulated genes, the GLK–GBF regulatory module likely serves as a common mechanism underlying GLK‐regulated photosynthetic pigment biosynthesis and chloroplast development.

Our findings uncover a novel regulatory machinery of carotenoid biosynthesis, discover a molecular mechanism of transcriptional regulation by GLKs, and divulge GLKs as important regulators to coordinate photosynthetic pigment synthesis in plants.

01 Apr 2025·Journal of Integrative Plant Biology

MpRR‐MYB2 and MpRR‐MYB5: New players of chloroplast biogenesis

Article

Author: Singh, Vijay Pratap ; Tripathi, Durgesh Kumar ; Kushwaha, Ajayraj ; Gupta, Ravi ; Zheng, Bing Song ; Singh, Samiksha

Photosynthesis is an essential biological process that occurs within chloroplasts. Recently, Frangedakis et al. (2024) reported that transcription factors- MpRR-MYB2 and MpRR-MYB5 work along with GLK, and also play a role in chloroplast development. The findings from this research could pave the way for engineering crops with enhanced photosynthetic efficiency.

Analysis

Perform a panoramic analysis of this field.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

MAP4K3

Basic Info

Related

Analysis