BICD1

Last update 08 May 2025

Basic Info

Synonyms

Bic-D 1, BICD cargo adaptor 1, BICD1

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Introduction

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

100 Clinical Results associated with BICD1

100 Translational Medicine associated with BICD1

0 Patents (Medical) associated with BICD1

Literatures (Medical) associated with BICD1

01 Jul 2024·Molecular Carcinogenesis

Baicalein promotes KDM4E to induce BICD1 and inhibit triple‐negative breast cancer progression by blocking PAR1 signaling

Article

Author: Pan, Meitong ; Dong, Yun ; Chen, Kun ; Xia, Jiyi ; Yu, Xiaolan ; He, Gaojian ; He, Xuefeng ; Huang, Xuemei

AbstractBaicalein has been implicated in the chemotherapy overcoming triple‐negative breast cancer (TNBC). However, many unanswered questions remain regarding its role in treating TNBC. Here, we sought to demonstrate the molecular pathway mediated by baicalein in TNBC. Lysine‐specific demethylase 4E (KDM4E), reduced in TNBC cells, was identified as a target protein of baicalein, and baicalein enhanced the protein expression and stability of KDM4E in TNBC cells. Knockdown of KDM4E attenuated the inhibitory effect of baicalein on TNBC cell activity, as demonstrated by intensified mobility, viability, and apoptosis resistance in TNBC cells. KDM4E activated protein bicaudal D homolog 1 (BICD1) expression by reducing the deposition of histone H3 lysine 9 trimethylation (H3K9me3) in its promoter, whereas BICD1 promoted protease‐activated receptor‐1 (PAR1) endocytosis and blocked PAR1 signaling through physical interaction with PAR1. Knockdown of KDM4E strengthened the PAR1‐dependent activity of TNBC cells in response to thrombin activation, whereas TNBC progression activated by PAR1 signaling was blocked by combined overexpression of BICD1. Taken together, our data indicate that baicalein‐promoted KDM4E enhanced the expression of BICD1 and activated the inhibitory effect of BICD1 on PAR1 signaling, thereby inhibiting TNBC progression.

15 Apr 2023·Journal of Cell Science

Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing

Article

Author: Krogsgaard, Michael R. ; Yeung, Ching-Yan Chloé ; Kjaer, Michael ; Mackey, Abigail L. ; Hoegsbjerg, Christian ; Koch, Manuel ; Denz, Linda ; Karlsen, Anders ; Schiaffino, Stefano ; Schjerling, Peter ; Jakobsen, Jens R.

ABSTRACTThe myotendinous junction (MTJ) is a specialized domain of the multinucleated myofibre that is faced with the challenge of maintaining robust cell–matrix contact with the tendon under high mechanical stress and strain. Here, we profiled 24,124 nuclei in semitendinosus muscle–tendon samples from three healthy males by using single-nucleus RNA sequencing (snRNA-seq), alongside spatial transcriptomics, to gain insight into the genes characterizing this specialization in humans. We identified a cluster of MTJ myonuclei represented by 47 enriched transcripts, of which the presence of ABI3BP, ABLIM1, ADAMTSL1, BICD1, CPM, FHOD3, FRAS1 and FREM2 was confirmed at the MTJ at the protein level in immunofluorescence assays. Four distinct subclusters of MTJ myonuclei were apparent, comprising two COL22A1-expressing subclusters and two subclusters lacking COL22A1 expression but with differing fibre type profiles characterized by expression of either MYH7 or MYH1 and/or MYH2. Our findings reveal distinct myonuclei profiles of the human MTJ, which represents a weak link in the musculoskeletal system that is selectively affected in pathological conditions ranging from muscle strains to muscular dystrophies.

01 Feb 2023·Journal of Cutaneous Pathology

Reconsideration of the pathogenic significance of kinase gene fusion in melanocytic tumors based on a case of melanoma with non‐in‐frame BICD1::BRAF fusion

Article

Author: Sudo, Tamotsu ; Goto, Keisuke ; Kajimoto, Kazuyoshi ; Takai, Toshihiro

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BICD1

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