ENKD1

Last update 08 May 2025

Basic Info

Synonyms

C16orf48, DKFZP434A1319, ENKD1

+ [3]

Introduction

Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35072334, PubMed:35197565). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795).

100 Clinical Results associated with ENKD1

100 Translational Medicine associated with ENKD1

0 Patents (Medical) associated with ENKD1

Literatures (Medical) associated with ENKD1

01 Mar 2025·Cell Reports

ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

Article

Author: Chen, Xiangrong ; Nie, Xiaotong ; Xu, Wenqing ; Wang, Jie ; Zhang, Tianyu ; Li, Chaojun ; Li, Tianliang ; Wang, Yixuan ; Yang, Ruqian ; Jin, Yueyi ; Li, Yan ; Song, Ting ; Chen, Xiangfeng ; Xie, Wei ; Wu, Sijin ; Sun, Lulu ; Zhou, Jun

Inflammation is a crucial element of immune responses, with pivotal roles in host defenses against pathogens. Comprehensive understanding of the molecular mechanisms underlying inflammation is imperative for developing effective strategies to combat infectious diseases. Here, we conducted a screening analysis and identified enkurin domain-containing protein 1 (ENKD1) as a promising regulator of inflammation. We observed that ENKD1 expression was significantly reduced on activation of multiple Toll-like receptor (TLR) molecules. Deletion of ENKD1 resulted in enhanced innate immune system activation and exacerbation of septic inflammation. Mechanistically, ENKD1 interacted with geranylgeranyl diphosphate synthase 1 (GGPS1) and modulated its enzymatic activity, thereby influencing geranylgeranyl diphosphate production. This interaction ultimately led to Ras-related C3 botulinum toxin substrate 1 (RAC1) inactivation and suppression of pro-inflammatory signaling pathways. Our findings establish ENKD1 as a critical regulator of innate immune cell activation, underscoring its significant role in septic inflammation.

01 Dec 2024·Advanced Science

CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments

Article

Author: Yang, Song ; Yang, Mulin ; Ran, Jie ; Yang, Yunfan ; Zhai, Denghui ; Hao, Huijie ; Liu, Min ; Lu, Quanlong ; Ni, Hua ; Bu, Weiwen ; Zhou, Jun ; Ma, Nan ; Li, Te ; Song, Ting ; Wang, Weishu ; Yoshida, Sei ; Yin, Hanxiao ; Wu, Xuemei ; Yu, Fan ; Yang, Jia ; Li, Dengwen

AbstractPhagocytosis of shed photoreceptor outer segments by the retinal pigment epithelium (RPE) is essential for retinal homeostasis. Dysregulation of the phagocytotic process is associated with irreversible retinal degenerative diseases. However, the molecular mechanisms underlying the phagocytic activity of RPE cells remain elusive. In an effort to uncover proteins orchestrating retinal function, the cylindromatosis (CYLD) deubiquitinase is identified as a critical regulator of photoreceptor outer segment phagocytosis. CYLD‐deficient mice exhibit abnormal retinal structure and function. Mechanistically, CYLD interacts with enkurin domain containing protein 1 (ENKD1) and deubiquitinates ENKD1 at lysine residues K141 and K242. Deubiquitinated ENKD1 interacts with Ezrin, a membrane‐cytoskeleton linker, and stimulates the microvillar localization of Ezrin, which is essential for the phagocytic activity of RPE cells. These findings thus reveal a crucial role for the CYLD‐ENKD1‐Ezrin axis in regulating retinal homeostasis and may have important implications for the prevention and treatment of retinal degenerative diseases.

01 Jun 2023·Journal of cellular physiology

Upregulation of ENKD1 disrupts cellular homeostasis to promote lymphoma development.

Article

Author: Hao, Ziqian ; He, Na ; Song, Ting ; Yang, Yunfan

Diffuse large B cell lymphoma (DLBCL) is a common and aggressive form of B cell lymphoma. Approximately 40% of DLBCL patients are incurable despite modern therapeutic approaches. To explore the molecular mechanisms driving the growth and progression of DLBCL, we analyzed genes with differential expression in DLBCL using the Gene Expression Profiling Interactive Analysis database. Enkurin domain-containing protein 1 (ENKD1), a centrosomal protein-encoding gene, was found to be highly expressed in DLBCL samples compared with normal samples. The phylogenetic analysis revealed that ENKD1 is evolutionarily conserved. Depletion of ENKD1 in cultured DLBCL cells induced apoptosis, suppressed cell proliferation, and blocked cell cycle progression in the G2/M phase. Moreover, ENKD1 expression positively correlates with the expression levels of a number of cellular homeostatic regulators, including Sperm-associated antigen 5, a gene encoding an important mitotic regulator. These findings thus demonstrate a critical function for ENKD1 in regulating the cellular homeostasis and suggest a potential value of targeting ENKD1 for the treatment of DLBCL.

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ENKD1

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