Last update 01 Nov 2024

ANKK1

Last update 01 Nov 2024

Basic Info

Synonyms

ANKK1, ankyrin repeat and kinase domain containing 1, Ankyrin repeat and protein kinase domain-containing protein 1

+ [5]

Introduction-

100 Clinical Results associated with ANKK1

100 Translational Medicine associated with ANKK1

0 Patents (Medical) associated with ANKK1

329

Literatures (Medical) associated with ANKK1

02 Jan 2024·Archives of Suicide Research

Genetic Variants Associated with Suicide Risk in the Mexican Population: A Systematic Literature Review

Review

Author: Sánchez-Domínguez, Celia Nohemí ; Marino-Martínez, Iván Alberto ; Garcia-Quiñones, Juan Angel ; Serna-Rodríguez, María Fernanda ; Rivas-Estilla, Ana María ; Pérez-Maya, Antonio Alí

Suicide is defined as the action of harming oneself with the intention of dying. It is estimated that worldwide, one person dies by suicide every 40 s, making it a major health problem. Studies in families have suggested that suicide has a genetic component, so the search for genetic variants associated with suicidal behavior could be useful as potential biomarkers to identify people at risk of suicide. In Mexico, some studies of gene variants related to neurotransmission and other important pathways have been carried out and potential association of variants located in the following genes has been suggested: SLC6A4, SAT-1, TPH-2, ANKK1, GSHR, SCARA50, RGS10, STK33, COMT, and FKBP5. This systematic review shows the genetic studies conducted on the Mexican population. This article contributes by compiling the existing information on genetic variants and genes associated with suicidal behavior, in the future could be used as potential biomarkers to identify people at risk of suicide.

01 Jan 2024·CNS & Neurological Disorders - Drug Targets

Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia

Article

Author: Khasawneh, Ramada R ; Abu-El-Rub, Ejlal ; Gerges, Romany H ; Almahasneh, Fatimah

Abstract:Nicotine dependence has deleterious neurological impacts. Previous studies found an association between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent cognitive decline. Smoking is considered the third most common risk factor for dementia, which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and varenicline. However, based on smokers’ genetic makeup, pharmacogenetics can be used to develop novel therapies to replace these traditional approaches. Genetic variability of cytochrome P450 2A6 has a major impact on smokers’ behavior and their response to quitting therapies. Gene polymorphism in nicotinic acetylcholine receptor subunits also has a great influence on the ability to quit smoking. In addition, polymorphism of certain nicotinic acetylcholine receptors was found to affect the risk of dementia and the impact of tobacco smoking on the development of Alzheimer's disease. Nicotine dependence involves the activation of pleasure response through the stimulation of dopamine release. Central dopamine receptors, catechol-o-methyltransferase and the dopamine transporter protein, regulate synaptic dopamine levels. The genes of these molecules are potential targets for novel smoking cessation drugs. Pharmacogenetic studies of smoking cessation also investigated other molecules, such as ANKK1 and dopamine-beta-hydroxylase (DBH). In this perspective article, we aim to highlight the promising role of pharmacogenetics in the development of effective drugs for smoking cessation, which can increase the success rate of smoking quitting plans and ultimately reduce the incidence of neurodegeneration and dementia.

01 Sep 2023·Biological Psychiatry

The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D2 Receptor-Expressing Neurons

Article

Author: Rodrigues-Lima, Fernando ; Hassouna, Rim ; Bosch-Bouju, Clémentine ; Small, Dana M ; Walle, Roman ; Foppen, Ewout ; Trifilieff, Pierre ; Hutelin, Zach ; Gangarossa, Giuseppe ; Montalban, Enrica ; Petitbon, Anna ; Perszyk, Emily ; Martin, Claire ; Castel, Julien ; Fang, Xi ; Mickus, Sophie ; Ansoult, Anthony ; Cebrian-Serrano, Alberto ; Luquet, Serge ; Berthelet, Jérémy

BACKGROUNDA large body of evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the TaqIA polymorphism is one of the most commonly studied in psychiatry. TaqIA is located in the gene that codes for the ankyrin repeat and kinase domain containing 1 kinase (Ankk1) near the dopamine D₂ receptor (D2R) gene. Homozygous expression of the A1 allele correlates with a 30% to 40% reduction of striatal D2R, a typical feature of addiction, overeating, and other psychiatric pathologies. The mechanisms by which the variant influences dopamine signaling and behavior are unknown.METHODSHere, we used transgenic and viral-mediated strategies to reveal the role of Ankk1 in the regulation of activity and functions of the striatum.RESULTSWe found that Ankk1 is preferentially enriched in striatal D2R-expressing neurons and that Ankk1 loss of function in the dorsal and ventral striatum leads to alteration in learning, impulsivity, and flexibility resembling endophenotypes described in A1 carriers. We also observed an unsuspected role of Ankk1 in striatal D2R-expressing neurons of the ventral striatum in the regulation of energy homeostasis and documented differential nutrient partitioning in humans with or without the A1 allele.CONCLUSIONSOverall, our data demonstrate that the Ankk1 gene is necessary for the integrity of striatal functions and reveal a new role for Ankk1 in the regulation of body metabolism.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

ANKK1

Basic Info

Related

Analysis