GABRQ

Last update 23 Jan 2025

Basic Info

Synonyms

GABA(A) receptor subunit theta, GABA(A) receptor, theta, GABRQ

+ [3]

Introduction

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

100 Clinical Results associated with GABRQ

100 Translational Medicine associated with GABRQ

0 Patents (Medical) associated with GABRQ

135

Literatures (Medical) associated with GABRQ

01 Mar 2023·Pest Management Science

Synthesis and activity‐detection of photoswitchable ligands with fipronil to insect

Article

Author: Huang, Qiu‐Tang ; Cheng, Jia‐Gao ; Ji, Yun‐Fan ; Shao, Xu‐Sheng ; Xu, Qi ; Du, Yao‐Yao ; Li, Zhong ; Zhou, Cong ; Xu, Zhi‐Ping ; Hou, Qing‐Qing ; Zhao, Chun‐Qing

AbstractBACKGROUNDIonotropic γ‐aminobutyric acid (GABA) receptor (GABAR) in an insect is the major inhibitory receptor and is one of the most important targets for insecticides. Due to the high spatiotemporal resolution of GABAR, the photopharmacological ligands acting on it in vertebrates but not insect have been developed.RESULTSIn this study, two types of photochromic ligands (PCLs) including DTFIPs (DTFIP1 and DTFIP2) and ABFIPs (p‐, m‐, and o‐ABFIP) were synthesized by incorporating photoswitch azobenzene or dithienylethene into fipronil (FIP), which is the antagonist of insect GABAR. Their photomodulation was measured by mosquito larval behavior, and their potential action mechanism was explored by the two‐electrode voltage clamp (TEVC) technique in vitro. DTFIP1 and m‐ABFIP exhibited the most significant difference of insecticidal activity by about 90‐ and 5‐fold to mosquito larvae between non‐irradiated and irradiated formation, respectively, and allowed for optical control of mosquito swimming activity. TEVC assay results indicated that m‐ABFIP and DTFIP1 enable optical control over the homomeric LsRDL‐type GABAR, which is achieved by regulating the chloride channel of resistance to dieldrin (RDL)‐type GABAR by photoisomerization.CONCLUSIONOur results suggested that PCLs synthesized from fipronil provide an alternative and precise tool for studying insect ionotropic GABARs and GABA‐dependent behavior. © 2022 Society of Chemical Industry.

01 Feb 2023·Neurogastroenterology & Motility

Regulation of the central amygdala on intestinal motility and behavior via the lateral hypothalamus in irritable bowel syndrome model mice

Article

Author: Chen, Ziyi ; Gao, Shengli ; Ming, Xing ; Ji, Pengfei ; Guo, Feifei ; Guo, Ruixiao ; Yu, Lizheng ; He, Xiaoman ; Zhang, Hongfei

AbstractBackgroundImpaired bidirectional communication between the gastrointestinal tract and the central nervous system (CNS) is closely related to the development of irritable bowel syndrome (IBS). Studies in patients with IBS have also shown significant activation of the hypothalamus and amygdala. However, how neural circuits of the CNS participate in and process the emotional and intestinal disorders of IBS remains unclear.MethodsThe GABAergic neural pathway projecting from the central amygdala (CeA) to the lateral hypothalamus (LHA) in mice was investigated by retrograde tracking combined with fluorescence immunohistochemistry. Anxiety, depression‐like behavior, and intestinal motility were observed in the water‐immersion restraint stress group and the control group. Furthermore, the effects of the chemogenetic activation of the GABAergic neural pathway of CeA‐LHA on behavior and intestinal motility, as well as the co‐expression of orexin‐A and c‐Fos in the LHA, were explored.Key ResultsIn our study, Fluoro‐Gold retrograde tracking combined with fluorescence immunohistochemistry showed that GABAergic neurons in the CeA were projected to the LHA. The microinjection of the gamma‐aminobutyric acid (GABA) receptor antagonist into the LHA relieved anxiety, depression‐like behavior, and intestinal motility disorder in the IBS mice. The chemogenetic activation of GABAergic neurons in the CeA‐LHA pathway led to anxiety, depression‐like behavior, and intestinal motility disorder. In addition, GABAergic neurons in the CeA‐LHA pathway inhibited the expression of orexin‐A in the LHA, and orexin‐A was co‐expressed with GABAA receptors.Conclusions & InferencesThe CeA‐LHA GABAergic pathway might participate in the occurrence and development of IBS by regulating orexin‐A neurons.

01 Dec 2022·Alzheimer's Research & TherapyQ2 · MEDICINE

The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

Q2 · MEDICINE

ArticleOA

Author: Singleton, E H ; Papma, J M ; Ossenkoppele, R ; Rabinovici, G D ; Scheltens, P ; Pijnenburg, Y A L ; Gami-Patel, P ; Seelaar, H ; Spina, S ; Grinberg, L T ; Nana, A L ; Boon, B D C ; Bouwman, F ; Seeley, W W ; Dijkstra, A A

AbstractBackgroundThe neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neuronal populations show a selective loss in bvAD.MethodsVENs and GABA receptor subunit theta (GABRQ)-immunoreactive pyramidal neurons of the anterior cingulate cortex (ACC) were quantified in post-mortem tissue of patients with bvAD (n = 9) and compared to typical AD (tAD, n = 6), bvFTD due to frontotemporal lobar degeneration based on TDP-43 pathology (FTLD, n = 18) and controls (n = 13) using ANCOVAs adjusted for age and Bonferroni corrected. In addition, ratios of VENs and GABRQ-immunoreactive (GABRQ-ir) pyramidal neurons over all Layer 5 neurons were compared between groups to correct for overall Layer 5 neuronal loss.ResultsThe number of VENs or GABRQ-ir neurons did not differ significantly between bvAD (VENs: 26.0 ± 15.3, GABRQ-ir pyramidal: 260.4 ± 87.1) and tAD (VENs: 32.0 ± 18.1, p = 1.00, GABRQ-ir pyramidal: 349.8 ± 109.6, p = 0.38) and controls (VENs: 33.5 ± 20.3, p = 1.00, GABRQ-ir pyramidal: 339.4 ± 95.9, p = 0.37). Compared to bvFTD, patients with bvAD showed significantly more GABRQ-ir pyramidal neurons (bvFTD: 140.5 ± 82.658, p = 0.01) and no significant differences in number of VENs (bvFTD: 10.9 ± 13.8, p = 0.13). Results were similar when assessing the number of VENs and GABRQ-ir relative to all neurons of Layer 5.DiscussionVENs and phylogenetically related neurons did not show a selective loss in the ACC in patients with bvAD. Our results suggest that, unlike in bvFTD, the clinical presentation in bvAD may not be related to the loss of VENs and related neurons in the ACC.

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