Beacon Secures $170M for Pivotal Eye Disease Gene Therapy Study

15 July 2024
Beacon Therapeutics has successfully secured $170 million through a Series B financing round, which is set to propel the development of its foremost gene therapy product, AGTC-501 (laruparetigene zovaparvovec), aimed at treating X-linked retinitis pigmentosa (XLRP). This significant financial backing includes over $40 million from Syncona, the company that initiated Beacon last year, along with contributions from Forbion, Oxford Science Enterprises, TCGX, and Advent Life Sciences.

David Fellows, the CEO of Beacon Therapeutics, highlighted the strategic importance of this funding. He stated, "These funds will support the ongoing development of our late-stage and preclinical pipeline and enable acceleration of the development of AGTC-501, as we progress through the clinic and toward commercialisation." The company's commitment to advancing their lead candidate is evident as they continue to push forward in clinical trials.

AGTC-501 recently marked a significant milestone with the treatment of its first patient in the registrational VISTA study. This Phase II/III trial is anticipated to provide results in 2026, which could potentially pave the way for future commercialization efforts. The therapy is being developed to address X-linked retinitis pigmentosa, a genetic condition that leads to progressive vision loss and blindness, primarily affecting males.

In addition to the development of AGTC-501, Beacon Therapeutics plans to utilize the newly acquired funds to advance other key projects within their portfolio. This includes generating Phase I/II data for a dry age-related macular degeneration program, which is currently in the preclinical stage. The company is also working on another asset focused on cone rod dystrophy, further emphasizing their dedication to addressing various eye-related genetic disorders.

The influx of $170 million will not only support the clinical progression of AGTC-501 but also enable Beacon Therapeutics to expedite the development of their broader pipeline. This financial boost provides the necessary resources for the company to continue its innovative research and development efforts, ultimately aiming to bring effective gene therapies to patients in need.

Beacon Therapeutics is poised to make significant strides in the field of gene therapy, particularly with its lead asset, AGTC-501, and the promising programs targeting other retinal diseases. The commitment from investors and the successful funding round underscore the potential and importance of Beacon's work in developing treatments for genetic eye disorders.

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