On July 9th, 2024, the U.S. FDA gave the green light to
Arcutis Biotherapeutics'
ZORYVE® (roflumilast) for the treatment of
atopic dermatitis (AD), the most prevalent form of
eczema affecting millions in the United States. This innovative, steroid-free cream is designed for once-daily use and has the potential to set a new benchmark in the management of AD. The approval highlights the increasing significance of
Phosphodiesterase 4 (PDE4) and other
PDEs as critical targets in the treatment of various inflammatory conditions.
Sino Biological and its subsidiary
SignalChem Biotech are actively supporting drug discovery and development related to PDEs by offering a wide array of PDE families and isoforms.
Roflumilast functions as a phosphodiesterase-4 (PDE4) inhibitor. Its primary action is to reduce
inflammation by elevating levels of cyclic adenosine monophosphate (cAMP), a crucial molecule in the inflammatory response regulation. PDE4 breaks down cAMP and has four subtypes:
PDE4A,
PDE4B,
PDE4C, and
PDE4D, with about 20 different isoforms. The anti-inflammatory effects of PDE4 inhibitors such as roflumilast mainly stem from their inhibition of the PDE4B and PDE4D subtypes, which are highly expressed in immune cells. By inhibiting these subtypes, roflumilast increases cAMP levels, which leads to a reduction in pro-inflammatory mediators such as
TNF alpha,
IL-4,
IL-5,
IL-13,
IL-17A,
IL-17F, and
IL-22, while boosting the anti-inflammatory mediator
IL-10. This mechanism helps manage inflammatory conditions like atopic dermatitis by alleviating symptoms such as
redness,
itching, and
swelling.
Phosphodiesterases (PDEs) play a vital role in controlling essential body functions by regulating the levels of cAMP and cyclic guanosine monophosphate (cGMP). Various
PDE inhibitors have been developed for a range of diseases, including
PDE1/2 inhibitors for
cardiovascular and neurological disorders, PDE4 inhibitors for
chronic obstructive pulmonary disease (COPD) and atopic dermatitis,
PDE5 inhibitors for
erectile dysfunction and
pulmonary arterial hypertension,
PDE6 inhibitors for
retinal diseases, and
PDE7 inhibitors for inflammatory and autoimmune conditions. Overall, PDE inhibitors represent powerful tools with significant potential as drug targets for a wide array of therapeutic applications.
Sino Biological and its subsidiary SignalChem Biotech are leading the charge in advancing drug development by offering an extensive variety of recombinant PDE families and isoforms. This initiative is aimed at facilitating research on PDEs. By partnering with these organizations, researchers can access a comprehensive range of resources to expedite their studies and development efforts in the field of PDEs.
This FDA approval not only marks a significant milestone for Arcutis Biotherapeutics but also underscores the critical role of PDE4 inhibitors in treating inflammatory diseases. As research continues to advance, the availability of diverse PDE families and isoforms from companies like Sino Biological and SignalChem Biotech will be indispensable in discovering and developing new therapies for a variety of conditions.
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