A recent study delves into the effects of
CYP2C9 genetic polymorphisms on the pharmacokinetics (PK) of
delta-9-tetrahydrocannabinol (THC) and its metabolites in
Alzheimer’s disease (AD) patients. The research, titled "A study on CYP2C9 polymorphism, in Puerto Rican Alzheimer's patients and its role in the Pharmacokinetics of ∆-9-tetrahydrocannabinol," is accessible through the European Society of Medicine.
The study underscores the significant role that CYP2C9 polymorphisms play in the metabolism of THC. Notably, it reveals substantial differences in the half-life of THC and OH-THC across various CYP2C9 phenotypes. These differences highlight the importance of personalized dosing strategies to enhance the efficacy and safety of AD treatments.
Ram Mukunda, CEO of
IGC Pharma, emphasized the importance of this research by stating, "We are thrilled to share this significant publication in the European Society of Medicine journal. This research exemplifies our dedication to advancing Alzheimer’s treatment through innovative science. Understanding genetic influences on drug metabolism is vital for developing safe and effective therapies."
The research, conducted with a cohort from Puerto Rico, aligns with IGC Pharma’s commitment to inclusive clinical research. Puerto Rico was chosen due to its higher prevalence of Alzheimer’s, which stands at 12% compared to 10.7% in the continental United States. This strategic choice ensures comprehensive data collection and enhances the accessibility of improved therapies.
IGC Pharma’s leading candidate, IGC-AD1, was evaluated in a phase 1 multiple ascending dose (MAD) trial. The findings from this study support the potential for personalized medicine in treating Alzheimer’s. Dr. Jagadeesh Rao, the study’s lead scientist, explained, "Our findings highlight the necessity of personalized medicine for Alzheimer’s care. The variability in THC metabolism due to CYP2C9 polymorphisms underscores the importance of genetic profiling in treatment plans. This paves the way for tailored therapeutic approaches and potentially better patient outcomes."
Currently, IGC Pharma is conducting a phase 2 trial for IGC-AD1, a partial CB1 receptor agonist with anti-neuroinflammatory properties and an inflammasome inhibitor. IGC-AD1 aims to address agitation symptoms in dementia caused by Alzheimer’s by utilizing THC as a primary active component. This innovative formulation represents a pioneering approach in Alzheimer’s therapy.
IGC Pharma, Inc. continues to lead Alzheimer’s research, focusing on transforming treatment paradigms for this debilitating disease. With a robust pipeline of five promising drug candidates, including IGC-AD1 and LMP, targeting neuroinflammation and hallmark Alzheimer’s symptoms, the company is dedicated to delivering breakthrough therapies. Their advanced research efforts also involve leveraging artificial intelligence (AI) to optimize clinical trials and enhance early detection of Alzheimer’s.
In conclusion, the study highlights the crucial role of understanding genetic polymorphisms in improving Alzheimer’s treatments. By tailoring THC doses based on genetic profiles, personalized medicine approaches can significantly enhance patient outcomes. As IGC Pharma advances its research and clinical trials, the prospects for innovative and effective Alzheimer’s therapies continue to grow.
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