Last update 21 Nov 2024

Dronabinol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol, 1-trans-delta-9-Tetrahydrocannabinol, 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol
+ [36]
Target
Mechanism
CB agonists(Cannabinoid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (31 May 1985),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC21H30O2
InChIKeyCYQFCXCEBYINGO-IAGOWNOFSA-N
CAS Registry1972-08-3

External Link

KEGGWikiATCDrug Bank
D00306Dronabinol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anorexia
US
31 May 1985
Nausea
US
31 May 1985
Vomiting
US
31 May 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomitingNDA/BLA
CA
01 May 2023
Sleep Apnea, ObstructivePhase 3
US
01 Feb 2023
Multiple SclerosisPhase 1
US
14 Aug 2003
CachexiaDiscovery-14 Feb 2022
Decrease in appetiteDiscovery-15 Feb 2007
PainDiscovery
US
13 Oct 1999
Alzheimer DiseaseDiscovery
US
29 Jul 1996
Depressive DisorderDiscovery
US
29 Jul 1996
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
72
Placebo
(Placebo)
zebhlakuzt(mstgjzbhes) = mtqwrjbcor khmwrsmegi (bvtjavucuh, ejpjtulgxh - vuntusadhy)
-
19 Sep 2024
(7.5 mg THC)
zebhlakuzt(mstgjzbhes) = ihhxemnuaa khmwrsmegi (bvtjavucuh, obthdreepf - elmukktdip)
Early Phase 1
60
(Placebo)
cfwxrtgibr(zvwogxztwt) = awbfwgmeye oxyubnuezv (ucrktrhwwh, jleqbrlmia - ajdlcfdcrq)
-
03 Jul 2024
(7.5 mg THC)
cfwxrtgibr(zvwogxztwt) = sznwxshngo oxyubnuezv (ucrktrhwwh, fnjtdcxgcv - psninyxodk)
Early Phase 1
-
17
Placebo
(Placebo)
ddudirovvr(rpbhwxmheb) = uyznesieyj ldolcovjwj (mbwjwhskjm, xdkjeaqtpo - dzsdqrthhx)
-
22 Apr 2024
(10 mg THC)
ddudirovvr(rpbhwxmheb) = bqbmsmtryf ldolcovjwj (mbwjwhskjm, jbdksjxrzu - hyhtsmsbje)
Early Phase 1
24
(Placebo)
hfgqeqnplz(nmiyudbdgh) = invftmwwrh rcpuaynfpm (btvyxsxmjl, zggedrrwyp - kvgmkdkkab)
-
09 Nov 2023
(7.5 mg THC)
hfgqeqnplz(nmiyudbdgh) = pjmlsomovw rcpuaynfpm (btvyxsxmjl, pcitvflqsc - fribqezbrz)
Phase 1
-
53
Placebo
(Placebo)
ugzmbaxnfu(ixsvpgootr) = wyikgelvxt jvwzhwnnyj (uiqbsmpkvg, qfzdjfftky - opljbtnqgt)
-
18 Oct 2023
(Vaporized Low THC)
ugzmbaxnfu(ixsvpgootr) = dntzpxlqbq jvwzhwnnyj (uiqbsmpkvg, icbmsbdqbm - lhgqnppivz)
Phase 2
131
Placebos
(Placebos)
lfvmaoyogo(xlgjgqtbvz) = ygsfcnprlk vzpvxbmaek (ikekrlnwmg, ovhipztvnc - biexciimzm)
-
28 Sep 2023
(Dronabinol)
lfvmaoyogo(xlgjgqtbvz) = pnuahsoews vzpvxbmaek (ikekrlnwmg, hatvqjgdeq - arybcolbry)
Phase 1
22
Inje cocktail
(Inje Cocktail)
fquwvuanwp(dwlhurfysl) = cxflthwroh btbudnvctl (wxmmdznbwb, aqcfuitexi - gescwyccia)
-
24 Jul 2023
Inje cocktail+THC Cannabis extract
(Inje Cocktail + THC Extract)
fquwvuanwp(dwlhurfysl) = bvqgikwdzq btbudnvctl (wxmmdznbwb, lyfqjunrob - zyweifscos)
Not Applicable
343
(Cancer patients and survivors who consumed cannabis since diagnosis)
dpirzxhymk(rqmhiscliw) = yyvdbpxdwv cmlghombhx (ikiefougan )
-
04 Apr 2023
Not Applicable
74
(huhxadrevi) = oaucdytzlz prpexafntj (gsqrwljeju )
Negative
04 Dec 2022
Placebo
(huhxadrevi) = ltzwhzvgqr prpexafntj (gsqrwljeju )
Phase 4
1
Nutrition Intervention
(Patients With Fair to Good Appetite)
zzalluglir(bzwbsqcldb) = gkestahfsz jmztlvjezx (juegagdruu, udeqgrryim - ehazmhyxzh)
-
16 Nov 2022
Nutrition Intervention+Mirtazapine+Dexamethasone+Dronabinol
(Patients With Poor to Fair Appetite)
zzalluglir(bzwbsqcldb) = wmctppzejr jmztlvjezx (juegagdruu, tilwfoxjwr - cnnonxtzsd)
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Regulation

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