IGNX001 Shows Promise for Peanut Allergy at 2024 EAACI Meeting Before Clinical Trials

IgGenix, Inc., a cutting-edge preclinical antibody discovery and development company, recently presented groundbreaking data at the 2024 European Academy of Allergy and Clinical Immunology (EAACI) Annual Meeting in Valencia, Spain. The company's pioneering SEQ SIFTER™ platform showcased its potential in discovering and characterizing IgE antibodies, specifically in Atopic Dermatitis (AD), and highlighted its lead candidate, IGNX001, designed to combat peanut allergies.

Revolutionary Approach to Allergy Treatment

IgGenix's leading therapeutic candidate, IGNX001, is an IgG4 monoclonal antibody-based treatment aimed at peanut allergies. The data presented demonstrated that IGNX001 effectively inhibits peanut-induced mast cell degranulation. This inhibition is crucial as it can serve as a reliable pharmacodynamic marker in clinical trials, indicating the potential effectiveness of the treatment.

"We are developing groundbreaking treatments for severe allergies, including peanut and other allergens," stated Derek Croote, Ph.D., Chief Technical Officer of IgGenix. "Our goal is to offer allergic patients protection against allergens within days rather than months. The SEQ SIFTER platform is revolutionizing our understanding of IgE biology, and we are thrilled to collaborate with our European partners on this innovative path."

Expanding the Horizons with SEQ SIFTER™ Platform

One of the significant highlights of the EAACI meeting was the introduction of the SEQ SIFTER™ platform. This proprietary technology enables the discovery of IgE antibodies involved in atopic diseases, including Atopic Dermatitis (AD). By leveraging this platform, IgGenix is making strides in identifying and characterizing IgE antibodies, which play a pivotal role in allergic reactions.

Oral Presentations at EAACI

Two key presentations during the EAACI meeting shed light on the capabilities of IgGenix's technologies:

1. “IGNX001 Inhibits Peanut-Mediated Mast Cell Activation in a Translational Spike-In Assay”
- Authors: Croote D., Bachmeier-Zbären N., Eggel A., Thomas GR., Lowman HB.
- Presenter: Derek Croote, Ph.D., IgGenix

2. "Discovery of Monoclonal IgE Autoantibodies from Atopic Dermatitis Patients"
- Authors: Croote D., Wen Wong JJ., Aruva V., Creeks P., Badloe F., Grossman J., Thomas GR., Lowman HB., Gutermuth J., Kortekaas-Krohn I.
- Presenter: Derek Croote, Ph.D., IgGenix

These presentations underscored the significant advances made by IgGenix in IgE-mediated disease research, showcasing the potential of their therapies to transform patient care.

IgGenix is set to initiate its first human clinical trial for peanut allergy later this year, marking a crucial milestone in the journey towards providing rapid and effective treatments for allergic patients. The trial will further evaluate the safety and efficacy of IGNX001, bringing the company one step closer to offering a viable alternative for managing severe allergies.

About IgGenix

IgGenix is a privately held company committed to revolutionizing the treatment of allergies and atopic diseases. Founded on research by Stephen Quake, Kari Nadeau, and Derek Croote from Stanford University, the company utilizes the SEQ SIFTER™ platform to isolate and re-engineer fully human, high-affinity, allergen-specific antibodies. These antibodies are designed to block and prevent allergic reactions, potentially saving lives and alleviating the constant fear experienced by millions of people with severe allergies.

The innovative approach taken by IgGenix aims to target common allergens and their key epitopes, offering treatment options for both pediatric and adult patients suffering from food and environmental allergies. By preventing life-threatening allergic reactions, IgGenix is poised to make a significant impact on the lives of those affected by severe allergies.

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