InsightRX Advances in Precision Dosing with Client Growth and New Scientific Breakthroughs

SAN FRANCISCO – InsightRX, a leader in cloud-based precision medicine software, is making significant strides in the health systems and life sciences sectors in 2024. Their platform, designed to optimize drug dosing by leveraging quantitative methods, is transforming traditional drug administration practices into a personalized, patient-focused approach.

InsightRX's precision-dosing platform integrates patient-specific and population-level data to refine therapeutic decisions. This approach has led to partnerships with over 780 hospitals and more than 150 health systems. To date, the company has personalized over 4 million dose recommendations across nearly one million treatment courses. Their Nova platform, which includes 100 drug modules with 150 validated pharmacokinetic-pharmacodynamic (PKPD) models, exemplifies their comprehensive drug data and modeling capabilities.

CEO and co-founder Sirj Goswami, Ph.D., expressed pride in InsightRX's role in shifting from a "one-size-fits-all" model to personalized patient care. This transition is supported by numerous accomplishments, including:

1. Enhanced Vancomycin PK Model for Patients with BMI < 40: InsightRX recommends the Modified Thomson model for patients with a BMI under 40, which showed superior accuracy in an analysis of over 168,000 patient treatment courses compared to three other models.

2. AI-powered FitAssist Feature: To improve model-informed precision dosing (MIPD) predictive accuracy, InsightRX developed FitAssist, which employs AI to evaluate the patient, PK model, and measured levels. This feature has enhanced prediction accuracy by up to 74%.

3. New Model for Class III Obesity: InsightRX collaborated with an academic health system to develop a new vancomycin model for patients with a BMI of 40 or more. This model demonstrated higher accuracy and reduced error rates in a review of over 28,000 treatment courses, and is recommended for patients with BMI > 40.

The Life Sciences sector is becoming a key growth area for InsightRX. Drug developers increasingly use InsightRX's cloud platform and clinical pharmacology services. Recent achievements include:

- First Industry-Sponsored Precision Dosing Clinical Trial: InsightRX partnered with a leading life sciences company to conduct a late-phase study focused on the pediatric population, relying exclusively on their Vantage Platform. This marks a significant milestone in precision dosing.

- Broad Application in Drug Development: InsightRX’s engagements with various drug compounds highlight the effectiveness of their Vantage Platform beyond early-phase trials. Their offerings now extend to preclinical stages, fulfilling a critical market need.

- Launch of Professional Services: In response to market demand, InsightRX introduced a professional services team comprising experienced clinicians, data scientists, and pharmacologists. This team provides comprehensive support including clinical pharmacology strategy, data services, modeling, and regulatory assistance.

Jason Rizzo, vice president of Life Sciences strategy and partnerships, emphasized the company’s strong foundation in serving industry partners. He highlighted the growing use of precision dosing in clinical trials and the increasing adoption of the Vantage Platform throughout a drug’s lifecycle.

Looking ahead, CEO Goswami outlined an expansive vision for InsightRX. The company aims to extend precision dosing solutions to more therapeutic areas in hospitals, expand into outpatient settings, and integrate advanced technologies such as large language models (LLMs). InsightRX aspires to make dose optimization a fundamental component of drug development from the beginning stages.

InsightRX continues to enhance therapeutic decision-making through their innovative cloud-based platform, demonstrating a commitment to personalized medicine and improved patient outcomes.

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