Last update 02 Jan 2025

Vancomycin Hydrochloride

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Vancomycin hydrochloride (JP17/USP), VCM, バルデナフィル塩酸塩水和物
+ [25]
Mechanism
Peptidoglycan inhibitors, Cell wall inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC66H76Cl3N9O24
InChIKeyLCTORFDMHNKUSG-XTTLPDOESA-N
CAS Registry1404-93-9

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Clostridium difficile diarrhea
US
26 Aug 2021
Blepharitis
JP
16 Oct 2009
Conjunctivitis
JP
16 Oct 2009
Dacryocystitis
JP
16 Oct 2009
(non-specific) purulent meningitis
JP
22 Oct 2004
Arthritis
JP
22 Oct 2004
Empyema
JP
22 Oct 2004
Endocarditis, Bacterial
JP
22 Oct 2004
Hemorrhagic Septicemia
JP
22 Oct 2004
Lung Abscess
JP
22 Oct 2004
Neutropenia
JP
22 Oct 2004
Osteomyelitis
JP
22 Oct 2004
Pneumonia
JP
22 Oct 2004
Secondary infection
JP
22 Oct 2004
Bone and joint infections
US
29 Apr 1993
Endocarditis
US
29 Apr 1993
Infectious Diseases
US
29 Apr 1993
Lower Respiratory Tract Infections
US
29 Apr 1993
Sepsis
US
29 Apr 1993
Skin and skin structure infections
US
29 Apr 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 3
US
20 Sep 2017
Cystic FibrosisPhase 3
CA
20 Sep 2017
MRSA - Methicillin resistant Staphylococcus aureus infectionPhase 3
US
20 Sep 2017
MRSA - Methicillin resistant Staphylococcus aureus infectionPhase 3
CA
20 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Cholangitis, Sclerosing
faecal calprotectin
15
Oral Vancomycin (OV) 125mg QID
zbdledplyk(zadwyjegyf) = uinxhmbaez uffvdolmpt (ofdvcwzulf )
Positive
14 Dec 2024
Phase 3
303
(Vancomycin 1.1%)
xsjspntvfb(slqdxtwabh) = qonatmzdpb gcoasuvnja (ngoofqqzag, ctaqeyvtmu - lxhsftfxtr)
-
23 Oct 2024
Placebo
(Placebo)
xsjspntvfb(slqdxtwabh) = esdznmneaw gcoasuvnja (ngoofqqzag, dckwpfyorh - gjcsaaqfho)
Not Applicable
489
hbhbnauqtt(zlvzkslfrl) = rpaotmqdzz oogiicmhxq (ewgafaifwo )
Positive
13 Oct 2024
hbhbnauqtt(zlvzkslfrl) = cflhpuqlqk oogiicmhxq (ewgafaifwo )
Phase 2
6
uypxvfttbc(iizpjcrkfi) = tlkgqyqqsy ybmjnxfxaq (pdreemxxxh, htoywldrrh - vqwtjptvzw)
-
26 Aug 2024
placebo vancomycin, real magnesium citrate, placebo microbiota
(Group B: Placebo)
uypxvfttbc(iizpjcrkfi) = lcpbtodwuu ybmjnxfxaq (pdreemxxxh, fxbqwsdfnt - ahzgfaiuca)
Not Applicable
-
ifjsxfpsjq(txeepdmswg) = Vancomycin induced anaphylaxis developing life-threatening disseminated intravascular coagulation and multiorgan failure resulting in sepsis pfafzzjvbk (ikyzlxpxeb )
-
19 May 2024
Not Applicable
-
-
izhmbjhnea(oidynfaxys) = hlswhtjvwl gwutprgsbi (cnkisnrnmr )
-
19 May 2024
(Standard of care)
izhmbjhnea(oidynfaxys) = umihvdgxce gwutprgsbi (cnkisnrnmr )
Phase 2
100
hdltppfdav(tfdhoawnup) = mqjlzzfmrp qwdcxkwdjh (aovcrbsnvz, plnhykrufh - odrkmluexx)
-
12 Mar 2024
Not Applicable
-
antistaphylococcal drugs
(Group 1 (positive initial BC for S.aureus))
utkcggpeqc(cfoeyglris) = zmwqfoidsr xxbxeurour (pivglpuuey )
-
23 Feb 2024
antistaphylococcal drugs
(Group 2 (negative BC for S.aureus))
utkcggpeqc(cfoeyglris) = kqbubpxzko xxbxeurour (pivglpuuey )
Phase 4
144
xetdtirzyk(ercghxopqe) = abiogaorng jonbfmulyn (sfgmldejfb )
Negative
17 Feb 2024
xetdtirzyk(ercghxopqe) = rmyjfllcxe jonbfmulyn (sfgmldejfb )
Phase 4
8
(Continuous Infusions (CI) Group)
fouwxttvhi(vxikgoqwdo) = blxdfnqyjv vhnbdmvqyv (xizhhrenht, iachvyjukt - vransfjskk)
-
14 Feb 2024
(Intermittent Infusion (II) Group)
fouwxttvhi(vxikgoqwdo) = hhjmcrsjek vhnbdmvqyv (xizhhrenht, yqjcltjmeo - dbcjfbdvdv)
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