What are the side effects of Aceclofenac?

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly prescribed for the relief of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. While effective in managing symptoms, Aceclofenac, like all medications, can have side effects, and it is important for patients to be aware of them.

Gastrointestinal Side Effects: One of the most common side effects of Aceclofenac is related to the gastrointestinal system. Patients may experience symptoms such as nausea, vomiting, abdominal pain, indigestion, and diarrhea. In some cases, more severe gastrointestinal issues such as gastric ulcers, bleeding, perforation, and gastritis can occur. These severe side effects are more likely with long-term use or in individuals with a history of gastrointestinal problems.

Cardiovascular Side Effects: Aceclofenac may also have effects on the cardiovascular system. It can lead to an increase in blood pressure and, in some cases, may contribute to the risk of serious cardiovascular events such as heart attack or stroke. This risk is particularly significant for individuals with pre-existing heart conditions or those using the medication for an extended period.

Renal Side Effects: The kidneys can be affected by the use of Aceclofenac. Some patients may experience a decrease in kidney function, and symptoms such as fluid retention, swelling (edema), and weight gain can occur. In rare cases, Aceclofenac can lead to more severe renal issues, including acute renal failure, especially in individuals with pre-existing kidney conditions or those taking other medications that affect kidney function.

Hepatic Side Effects: Aceclofenac can also impact liver function. Patients may experience increases in liver enzymes, which usually indicate liver inflammation or damage. Symptoms of liver issues include jaundice (yellowing of the skin and eyes), dark urine, severe fatigue, and pain in the upper right side of the abdomen. These symptoms necessitate immediate medical attention.

Allergic Reactions: Some individuals may experience allergic reactions to Aceclofenac, such as skin rashes, itching, and hives. In severe cases, anaphylactic reactions can occur, which require urgent medical intervention. Symptoms of anaphylaxis include difficulty breathing, swelling of the face and throat, and a rapid drop in blood pressure.

Central Nervous System Side Effects: Although less common, Aceclofenac can affect the central nervous system. Patients may experience dizziness, headache, and drowsiness. These side effects can impact the ability to perform tasks that require full attention, such as driving.

Hematological Side Effects: Aceclofenac can also influence blood cell counts. Some individuals may experience anemia (a decrease in red blood cells), leukopenia (a decrease in white blood cells), or thrombocytopenia (a decrease in platelets), which can lead to increased susceptibility to infections and issues with blood clotting.

Dermatological Side Effects: Skin-related side effects can occur, including rashes, itching, and photosensitivity (increased sensitivity to sunlight). In rare cases, severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may develop, both of which require immediate medical attention.

Respiratory Side Effects: Respiratory issues, although uncommon, can arise. Some patients may experience bronchospasm, especially those with pre-existing asthma or other respiratory conditions.

It is important to note that not everyone will experience these side effects, and their severity can vary from person to person. Patients should always consult their healthcare provider before starting Aceclofenac to discuss potential risks, especially if they have pre-existing conditions or are taking other medications. Regular monitoring and follow-up with the healthcare provider can help manage and mitigate any adverse effects that may arise during the course of treatment with Aceclofenac.