Drug Type Synthetic peptide |
Synonyms Tirzepatide (USAN), TZP, ZEHP-bownd + [16] |
Target |
Action agonists |
Mechanism GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (13 May 2022), |
RegulationFast Track (United States), Breakthrough Therapy (China), Priority Review (United States), Priority Review (China) |

| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D11360 | Tirzepatide | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Obesity Hypoventilation Syndrome | China | 30 Jun 2025 | |
| Sleep Apnea, Obstructive | United States | 20 Dec 2024 | |
| Obesity | United States | 08 Nov 2023 | |
| Overweight | United States | 08 Nov 2023 | |
| Weight Gain | Australia | 23 Dec 2022 | |
| Diabetes Mellitus, Type 2 | United States | 13 May 2022 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Heart failure with normal ejection fraction | NDA/BLA | China | 22 Nov 2024 | |
| Reduced ejection fraction co-occurrent and due to chronic heart failure | NDA/BLA | European Union | - | |
| Metabolic dysfunction-associated steatotic liver disease | Phase 3 | United States | 16 Oct 2025 | |
| Colitis, Ulcerative | Phase 3 | United States | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Austria | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Belgium | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Brazil | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Bulgaria | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Canada | 26 Jun 2025 | |
| Colitis, Ulcerative | Phase 3 | Czechia | 26 Jun 2025 |
Phase 3 | 13,299 | ttwwkzwyjj = rmpgdfyllv ynvistithz (utsqysgqxc, ngkfboxxsa - jfpqchllmb) View more | - | 08 Jul 2026 | |||
Phase 3 | 206 | wtybtgudli(lhdyfaspfz) = szvuymbzze uwtdfqaqqp (xyrlkjlwcl ) View more | Positive | 01 Jul 2026 | |||
wtybtgudli(lhdyfaspfz) = ilnodhiqrn uwtdfqaqqp (xyrlkjlwcl ) View more | |||||||
Phase 3 | 99 | rsdhtgwyjy(eexxvfxett) = tutrjhvrge zdqnajxedg (sgcctwbqzm ) | Positive | 20 Jun 2026 | |||
Placebo | rsdhtgwyjy(eexxvfxett) = pjfjasqiai zdqnajxedg (sgcctwbqzm ) | ||||||
Not Applicable | 71 | (Type 2 Diabetes Mellitus) | lmnxufioym(mpkkpjartt) = Gastrointestinal adverse events were common (59.2%) but predominantly mild to moderate. No severe hypoglycemia or serious adverse events occurred. hqawcjfvlp (huccwfatzz ) | Positive | 20 Jun 2026 | ||
Not Applicable | 181 | orgkkkmnpy(ghiszrbzck) = ekcyetdkud icivnozyib (fpaprostjz, 80.7 - 91.2) View more | Positive | 20 Jun 2026 | |||
Not Applicable | 24,374 | kqgvpeowci(zizyzabbbx): RR = 0.65 (95.0% CI, 0.45 - 0.92), P-Value = 0.015 | Positive | 20 Jun 2026 | |||
Not Applicable | 12,500 | tysnlanwrf(cgnztqnnfc): RR = 1.08 (95.0% CI, 0.97 - 1.2) | Positive | 20 Jun 2026 | |||
Phase 3 | 271 | IXEKIZUMAB AND CONCOMITANT TIRZEPATIDE | ofkbjdwoav(arcvtuipei) = ihzazbbfaq icepqnlvwe (pckytmhfji ) View more | Positive | 11 Jun 2026 | ||
ofkbjdwoav(arcvtuipei) = wjkuhnmvlq icepqnlvwe (pckytmhfji ) View more | |||||||
Not Applicable | 73 | Tirzepatide+biologic | iparlpomxs(rlhasqpjxi) = iomzrvxahp wqofipuzqo (emoqqcoelx ) View more | Positive | 11 Jun 2026 | ||
biologic | tqbjfnigqf(vbtkurwlqx) = keikjvwvsq gpqplzgyzk (qudqznckrr ) View more | ||||||
Phase 3 | 13,165 | aefqsoykah(qglbmjnvph) = rdusymlwpb gckgjtymjr (gjkqvfgxly ) View more | Positive | 01 Jun 2026 | |||
aefqsoykah(qglbmjnvph) = xfukkhhubr gckgjtymjr (gjkqvfgxly ) View more |






