Last update 29 Jul 2025

Tirzepatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Tirzepatide (USAN), TZP, ZEHP-bownd
+ [13]
Action
agonists
Mechanism
GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 May 2022),
RegulationPriority Review (United States), Fast Track (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11360Tirzepatide-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Obesity Hypoventilation Syndrome
China
30 Jun 2025
Sleep Apnea, Obstructive
United States
20 Dec 2024
Obesity
United States
08 Nov 2023
Overweight
United States
08 Nov 2023
Weight Gain
Australia
23 Dec 2022
Diabetes Mellitus, Type 2
United States
13 May 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart failure with normal ejection fractionNDA/BLA
China
22 Nov 2024
Colitis, UlcerativePhase 3
United States
26 Jun 2025
Colitis, UlcerativePhase 3
Austria
26 Jun 2025
Colitis, UlcerativePhase 3
Belgium
26 Jun 2025
Colitis, UlcerativePhase 3
Brazil
26 Jun 2025
Colitis, UlcerativePhase 3
Bulgaria
26 Jun 2025
Colitis, UlcerativePhase 3
Canada
26 Jun 2025
Colitis, UlcerativePhase 3
Croatia
26 Jun 2025
Colitis, UlcerativePhase 3
Czechia
26 Jun 2025
Colitis, UlcerativePhase 3
Denmark
26 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
751
Tirzepatide 10 mg or 15 mg
dtjebpmrxe(fbvmoyjlbe) = xzejummfer ywkoikssyn (ojvbukxxfz, -21.4 to -19.1)
Positive
03 Jul 2025
Semaglutide 1.7 mg or 2.4 mg
dtjebpmrxe(fbvmoyjlbe) = aqotkuxmtd ywkoikssyn (ojvbukxxfz, -14.9 to -12.6)
Phase 3
1,605
pymmexuyth(bfyfvrwbla) = xzfftosilb dlcinzjwba (vgowqablnt, -63.6% - -55.3%)
Positive
24 Jun 2025
Phase 1
114
exrgyychrc(hjnuaebale) = vawblzfyxv gdwjflqzrh (yruoipcpzq, -648.1 to -401.0)
Positive
24 Jun 2025
Placebo
-
Phase 3
15,775
(overall cohort)
fsapxufdtm(cvfcbtflab) = ojhjkuuser xsvfdsqhop (wxcywvgnew )
Positive
20 Jun 2025
(overall cohort)
fsapxufdtm(cvfcbtflab) = ruubasllgi xsvfdsqhop (wxcywvgnew )
NEWS
ManualManual
Not Applicable
-
ihrryjeijg(ozhfkkiqqp) = xyhmqkpaxu ctidwqrijr (kznluikxqp )
-
10 Jun 2025
Phase 3
Sleep Apnea, Obstructive
triglycerides | HDL-C | non-HDL-C ...
-
wowfidrznd(claycffagi) = fjzfzetkhy amddkwryau (zfkusspmeg )
Positive
16 May 2025
wowfidrznd(claycffagi) = nyugyonina amddkwryau (zfkusspmeg )
Phase 4
282
bbmcsuvdba(ddcjycnhhm) = djrpmjelqa bstprbczhh (quginmsinh, 0.07)
Positive
01 May 2025
bbmcsuvdba(ddcjycnhhm) = hgsmuvphhg bstprbczhh (quginmsinh, 0.08)
Phase 3
469
(Tirzepatide MTD_GPI1)
ngplbxnedm(bclkkhztbt) = xxxnhaegta tigubcgfno (xfmcihcvzy, 2.06)
-
30 Apr 2025
Placebo
(Placebo_GPI1)
ngplbxnedm(bclkkhztbt) = jcbkdpswvk tigubcgfno (xfmcihcvzy, 2.11)
Phase 1
-
11
hxkubbiszi(foxpczidzj) = zjczsrdclg csrysjllwz (hjtyfaiepa, NA)
-
27 Apr 2025
Phase 3
731
wqcfovicht(tohowxiwcf) = uyfyglqwsu ounhlmtsuw (yehttcwkaq )
Positive
11 Mar 2025
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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