What are the side effects of Entrectinib?

Entrectinib, marketed under the brand names Rozlytrek, is a targeted cancer therapy used primarily for treating specific types of tumors that display certain gene mutations, such as NTRK, ROS1, and ALK. While the drug holds promise for extending and improving the quality of life for cancer patients, it is not without its side effects. Understanding these side effects is crucial for patients and healthcare providers to manage them effectively and ensure optimal treatment outcomes.

One of the most common side effects of Entrectinib is fatigue. Patients often report feeling unusually tired and lacking energy. This can affect daily activities and overall quality of life. It is important for patients to communicate their levels of fatigue to their healthcare providers, as adjustments in dosage or supportive therapies may be necessary.

Gastrointestinal issues are another frequently reported side effect. Patients taking Entrectinib may experience nausea, vomiting, diarrhea, constipation, or abdominal pain. These symptoms can range from mild to severe and may require medications to manage them. Maintaining proper hydration and a balanced diet can also help alleviate some of these gastrointestinal symptoms.

Neurological side effects are also a concern with Entrectinib. Dizziness, headache, and changes in taste are commonly reported. More serious neurological effects include cognitive impairment and mood changes such as depression or anxiety. These symptoms should be closely monitored, and any sudden or severe changes should be reported to a healthcare provider immediately.

Cardiovascular issues are another potential side effect of Entrectinib. The drug can cause changes in heart rhythm, known as QT prolongation, which can be detected through an electrocardiogram (ECG). Patients may also experience symptoms such as palpitations, chest pain, or shortness of breath. Regular monitoring and timely intervention are essential to managing these risks.

Musculoskeletal side effects can manifest as muscle pain, joint pain, or weakness. These symptoms can affect mobility and physical activity levels. Over-the-counter pain relievers and physical therapy may help manage these side effects, but severe cases should be discussed with a healthcare provider for more targeted treatments.

Weight gain is another side effect that some patients may experience while taking Entrectinib. This can be particularly concerning for patients already dealing with cancer-related issues. Regular monitoring of weight and implementing dietary and lifestyle changes can help manage this side effect.

Additionally, liver function can be affected by Entrectinib. Elevated liver enzymes are often detected through routine blood tests. Symptoms of liver dysfunction may include jaundice (yellowing of the skin and eyes), dark urine, and abdominal pain. It is essential to regularly monitor liver function and adjust treatment as necessary.

Entrectinib can also affect the eyes, leading to vision changes such as blurred vision or increased sensitivity to light. Patients experiencing any changes in vision should seek prompt medical attention to prevent any long-term damage.

Other side effects may include skin reactions such as rash or itching, as well as decreased appetite. These symptoms can often be managed with topical treatments or dietary adjustments but should be discussed with a healthcare provider for appropriate management.

In summary, while Entrectinib offers significant benefits for treating certain types of cancer, it is associated with a range of potential side effects. Fatigue, gastrointestinal issues, neurological symptoms, cardiovascular problems, musculoskeletal pain, weight gain, liver dysfunction, vision changes, and skin reactions are among the most commonly reported. Ongoing communication with healthcare providers and regular monitoring are essential for managing these side effects and ensuring the best possible outcomes for patients undergoing treatment with Entrectinib.