What are the side effects of Erdafitinib?

Erdafitinib is a prescription medication used in the treatment of certain types of cancer, specifically bladder cancer. Like all medications, it comes with potential side effects that patients should be aware of. Understanding these side effects can help patients and healthcare providers manage and mitigate them effectively.

The most common side effects of Erdafitinib include dry mouth, dry eyes, increased phosphate levels in the blood (hyperphosphatemia), and changes in nail and skin. These side effects are typically mild to moderate in severity and can often be managed with supportive care measures.

One of the more frequently reported side effects is dry mouth. This can be uncomfortable but is generally manageable with good oral hygiene and the use of saliva substitutes or mouth moisturizers. Dry eyes are another common side effect, which can cause discomfort and can be managed with artificial tears or lubricating eye drops.

Hyperphosphatemia is a notable side effect of Erdafitinib. Elevated phosphate levels in the blood can lead to symptoms like muscle cramps and numbness. To manage this condition, dietary changes, medications to lower phosphate levels, and regular monitoring of blood phosphate levels may be necessary.

Changes in the appearance of nails and skin are also common. Patients might notice their nails becoming brittle, discolored, or even developing ridges. Skin changes can include dryness, rashes, or changes in pigmentation. Using moisturizers and protecting the skin from excessive sun exposure can help alleviate some of these symptoms.

Besides the common side effects, some patients may experience more serious adverse reactions. These include eye disorders such as central serous retinopathy and retinal pigment epithelial detachment, which can affect vision. Regular eye examinations are crucial for early detection and management of these conditions. If any changes in vision occur, patients should contact their healthcare provider immediately.

Other serious side effects can include hand-foot syndrome, where the palms of the hands or soles of the feet become red, swollen, and painful. This can interfere with daily activities and may require dose adjustments or temporary discontinuation of Erdafitinib.

Some patients might experience gastrointestinal issues such as diarrhea, which can lead to dehydration and electrolyte imbalances if not managed properly. Staying hydrated and using anti-diarrheal medications as prescribed can help control these symptoms.

Fatigue is another side effect that can significantly impact quality of life. It’s important for patients to balance rest and activity and to discuss any severe or persistent fatigue with their healthcare provider, as it may require adjustments to their treatment plan.

Lastly, like many cancer treatments, Erdafitinib can suppress the immune system, making patients more susceptible to infections. Good hygiene practices, staying away from sick individuals, and prompt treatment of any infections are essential precautions.

While Erdafitinib offers a valuable option in the fight against bladder cancer, being informed about its potential side effects enables patients and caregivers to take proactive steps in managing them. Regular communication with healthcare providers, consistent monitoring, and adherence to prescribed management strategies can help mitigate these side effects and improve the overall treatment experience.