What are the side effects of Lanadelumab?

Lanadelumab is a monoclonal antibody used primarily for the prevention of hereditary angioedema (HAE) attacks, a condition marked by recurrent episodes of severe swelling in various body parts. While it has proven effectiveness, like all medications, Lanadelumab can have side effects. Understanding these potential side effects is crucial for patients and healthcare providers to manage treatment effectively.

One of the most common side effects reported by patients taking Lanadelumab is injection site reactions. These reactions can include pain, redness, or swelling at the site where the medication is administered. Although these symptoms are generally mild to moderate and resolve on their own, they can cause discomfort and may be concerning for some patients.

In addition to injection site reactions, some individuals may experience upper respiratory tract infections. Symptoms of these infections can include a runny nose, sore throat, or cough. These infections are relatively common and usually not severe, but they can cause temporary discomfort and may require symptomatic treatment or medical attention if they worsen.

Dizziness is another reported side effect, albeit less common. Patients experiencing dizziness should be cautious when engaging in activities that require full alertness, such as driving or operating heavy machinery. If dizziness persists or becomes severe, it’s important to consult a healthcare provider.

Headaches have also been noted as a side effect. These can range from mild to moderate in intensity. Over-the-counter pain relief medications can often manage these headaches, but if they persist or are severe, further medical advice should be sought.

Muscle pain is another less frequently reported side effect. This can manifest as general discomfort or soreness in various muscle groups. Stretching, hydration, and over-the-counter pain relief can help manage this symptom, but persistent or severe muscle pain should be evaluated by a healthcare provider.

Although rarer, some patients may experience more serious side effects such as hypersensitivity reactions, which can include symptoms like rash, itching, or even more severe allergic responses such as difficulty breathing or swelling of the face, lips, or throat. These reactions require immediate medical attention and discontinuation of the medication.

One should also be aware of the potential for increased liver enzymes, which could indicate liver stress or damage. Regular monitoring through blood tests can help detect any liver-related issues early, allowing for timely intervention.

Lastly, patients with pre-existing conditions or those taking other medications should have a thorough discussion with their healthcare provider to understand any potential drug interactions or exacerbation of their current conditions.

In conclusion, while Lanadelumab is an effective treatment for preventing HAE attacks, it is not without side effects. Patients should be well-informed and maintain open communication with their healthcare provider to manage any adverse effects that may arise. Regular monitoring and prompt reporting of any unusual symptoms can help ensure safe and effective use of this medication.