What are the side effects of Mepolizumab?

Mepolizumab is a monoclonal antibody used primarily to treat severe eosinophilic asthma, a type of asthma characterized by high levels of eosinophils, a type of white blood cell. While Mepolizumab has proven to be effective in managing this condition, like all medications, it carries potential side effects. Understanding these side effects can help patients and healthcare providers make informed decisions about its use.

One of the most commonly reported side effects of Mepolizumab is headache. This can range from mild to moderate in severity and may occur shortly after the administration of the drug. Patients are advised to monitor their symptoms and consult their healthcare provider if headaches persist or worsen over time.

Injection site reactions are another frequent side effect. These reactions may include pain, redness, swelling, or itching at the site where the drug is injected. These reactions are typically mild and resolve on their own within a few days. However, in some cases, they can be more severe and require medical attention.

Infections, particularly of the respiratory tract, are also a noted side effect. While Mepolizumab can help manage asthma symptoms, it may also increase susceptibility to infections such as the common cold, sinusitis, or bronchitis. Patients should be vigilant for signs of infection, such as fever, cough, or nasal congestion, and seek medical advice if these symptoms occur.

Some patients may experience an allergic reaction to Mepolizumab. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat. An allergic reaction can occur shortly after the injection or even days later. Immediate medical attention is crucial if any signs of a severe allergic reaction are noticed.

Mepolizumab may also cause fatigue. Patients may feel unusually tired or weak, which can affect their daily activities. It is essential to report any significant changes in energy levels to a healthcare provider, as this may indicate the need for adjustment in treatment.

Less common side effects include back pain, upper abdominal pain, and urinary tract infections. Additionally, some patients have reported experiencing muscle spasms and joint pain after receiving Mepolizumab. While these side effects are less frequent, they can still be bothersome and should be discussed with a healthcare provider.

Overall, while Mepolizumab is a beneficial medication for many individuals with severe eosinophilic asthma, it is not without its potential side effects. Patients should be well-informed about these risks and maintain open communication with their healthcare providers to manage any adverse effects effectively. Ensuring regular follow-up appointments and promptly reporting any new or worsening symptoms can help in safely continuing the treatment and improving overall quality of life.