What is the mechanism of Cetraxate Hydrochloride?

Cetraxate Hydrochloride, a medication utilized for its gastroprotective properties, is primarily employed to treat peptic ulcers and other related gastrointestinal conditions. The mechanism of action of Cetraxate Hydrochloride involves multiple pathways, contributing to its efficacy in protecting and healing the gastric mucosa.

One of the primary mechanisms through which Cetraxate Hydrochloride operates is by enhancing the production of mucus in the stomach lining. Mucus serves as a protective barrier that shields the stomach lining from the corrosive effects of gastric acid and digestive enzymes. By increasing mucus secretion, Cetraxate Hydrochloride helps to fortify this barrier, thereby reducing the risk of ulcer formation and promoting ulcer healing.

Additionally, Cetraxate Hydrochloride has been shown to stimulate the production of prostaglandins within the gastric mucosa. Prostaglandins play a critical role in maintaining the integrity of the stomach lining by promoting mucus and bicarbonate secretion, enhancing mucosal blood flow, and inhibiting gastric acid secretion. By augmenting prostaglandin levels, Cetraxate Hydrochloride aids in reinforcing the stomach's natural defense mechanisms against ulcerogenic factors.

Another significant aspect of Cetraxate Hydrochloride's mechanism involves its ability to neutralize gastric acid. The drug has an antacid effect, which helps in reducing the acidity of the stomach contents. Lower acidity levels contribute to a less hostile environment for the gastric mucosa, thus preventing further irritation and allowing existing ulcers to heal more effectively.

Moreover, Cetraxate Hydrochloride exhibits cytoprotective properties by promoting the repair and regeneration of the gastric mucosal cells. This is achieved through the activation of cellular repair processes and enhancement of tissue regeneration. By supporting the natural healing processes, Cetraxate Hydrochloride facilitates the restoration of the damaged mucosa and accelerates the recovery from peptic ulcers.

In summary, the gastroprotective efficacy of Cetraxate Hydrochloride is attributed to its multifaceted mechanism of action, which includes enhancing mucus production, stimulating prostaglandin synthesis, neutralizing gastric acid, and promoting mucosal repair and regeneration. These combined actions contribute to its effectiveness in treating peptic ulcers and protecting the gastrointestinal mucosa from various ulcerogenic factors.