Enhanced Partnership for TG4050 Neoantigen Vaccine Phase I/II Trial

In a collaborative effort to enhance cancer treatment, Transgene, a biopharmaceutical company specializing in cancer immunotherapies, NEC Corporation, a frontrunner in IT and AI technologies, and BostonGene, a pioneer in AI-driven molecular profiling, have announced an expansion of their partnership. This collaboration aims to advance the Phase I/II clinical trials of TG4050, a personalized therapeutic vaccine for patients afflicted with head and neck cancers.

The alliance with BostonGene facilitates rapid tumor molecular profiling and microenvironment analysis, bolstered by high-throughput sequencing services. This partnership ensures swift processing of next-generation sequencing (NGS) data, enabling a detailed patient immune contexture analysis through advanced analytics.

TG4050 is an innovative immunotherapy that leverages Transgene's myvac® platform and NEC's AI-driven Neoantigen Prediction System. This system has been trained on proprietary data and is designed to identify and select patient-specific neoantigens, which are then encoded in the vaccine. The vaccine is tailored to each patient, aiming to stimulate their immune system to target and eradicate tumor cells based on these unique genetic mutations.

Dr. Alessandro Riva, CEO of Transgene, highlighted the significance of the collaboration, noting that it has provided valuable insights into patient phenotypes and the evolution of the tumor micro-environment post-treatment. Masamitsu Kitase, Corporate SVP at NEC, emphasized the collective expertise's role in streamlining the development and delivery of patient-specific vaccines, setting a new benchmark for head and neck cancer care.

Nathan Fowler, MD, Chief Medical Officer at BostonGene, expressed the company's commitment to supporting the clinical trials, noting that their profiling techniques offer a comprehensive analysis of the tumor, microenvironment, and immune system to predict treatment responses and improve patient outcomes.

Transgene's myvac® platform represents a significant stride in precision medicine, offering individualized immunotherapy that targets solid tumors using the patient's cancer-specific genetic mutations. The company has received funding from Bpifrance for the development of this platform, with TG4050 being the first product to undergo clinical evaluation.

NEC Corporation is recognized for its integration of IT and network technologies, contributing to a sustainable world by fostering safety, security, fairness, and efficiency. Their AI Drug Development Business is a testament to their commitment to innovation in healthcare.

BostonGene is dedicated to revolutionizing cancer care through AI-integrated molecular analytics, providing personalized roadmaps for therapeutic decision-making. Their multi-omic approach focuses on real-world impact, optimizing standard-of-care therapies, and accelerating research for measurable results.

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