Master Dextromethorphan Search on Synapse

Dextromethorphan (DXM) is a synthetic analog of codeine, but unlike codeine, it is not a narcotic and does not have the same potential for abuse or addiction. DXM is an N-methyl-D-aspartate (NMDA) receptor antagonist, NMDA receptors are involved in pain perception and the regulation of mood, learning, and memory. DXM is a sigma-1 receptor agonist,Sigma-1 receptors are involved in many different functions, including pain perception, mood regulation, and neuroprotection. Dextromethorphan is commonly used as a cough suppressant, and it has also been investigated for its potential therapeutic effects in a variety of conditions, including neuropathic pain, depression, and addiction. Dextromethorphan was successfully tested in 1954 as part of US Navy and CIA-funded research on nonaddictive substitutes for codeine. It was approved by the FDA in 1958 as an over-the-counter antitussive. Click on the image below to begin the exploration journey of Dextromethorphan through the Synapse database!

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