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PharmAbcine Begins Early-Stage PMC-309/KEYTRUDA Trial for Severe Solid Cancers

1 February 2024
3 min read

PharmAbcine Inc., an enterprise at the clinical developmental stage dedicated to pioneering antibody treatments, has declared the commencement of a Phase 1a/b study with the initiation of administering PMC-309 to individuals diagnosed with advanced or widespread solid neoplasms.

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The therapeutic agent PMC-309, a selective IgG1 monoclonal antibody, targets VISTA on cells that suppress immune function and demonstrates robust affinity for this molecule under the varying pH levels encountered in the tumor microenvironment. PMC-309 works by disrupting VISTA, adopting a distinct mode of action that leads to the encouragement of T cell activity, stimulation of monocytes, and enhanced growth of M1 macrophages, all of which contribute to its potential to combat cancer.

The planned clinical research involving PMC-309 is split into two stages: an initial Phase 1a followed by Phase 1b. The first phase will explore the solo application of PMC-309 as well as its use in conjunction with KEYTRUDA® (pembrolizumab), with an eye on identifying the highest dose that patients can tolerate and establishing the dose suggested for Phase 2 studies.

During the subsequent Phase 1b segment, the research will focus on assessing the safety and acceptability of both the solitary use of PMC-309 and its combined application with KEYTRUDA® at the determined recommended Phase 2 dose (RP2D). The investigation is set to be carried out across four research centers in Australia, aiming to involve a cohort of 67 individuals.

Dr. Jin-San Yoo, who holds the positions of President and CEO of PharmAbcine, expressed the following: "Our ongoing clinical investigation is directed toward evaluating the safety of PMC-309 in humans and investigating the therapeutic viability of using PMC-309 both alone and in combo with KEYTRUDA®. Our commitment is steadfast in offering innovative treatment avenues for cancer sufferers who are currently faced with limited options, underlining our resolve to push forward the progress of cancer therapies."

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According to the data provided by the Synapse Database, As of January 29, 2024, there are 18 investigational drugs for the VISTA target, including 28 indications, 24 R&D institutions involved, with related clinical trials reaching 10, and as many as 8762 patents.

PMC-309 targets VISTA and is being developed for the treatment of neoplasms, specifically solid tumors. The drug has reached Phase 1 of clinical development, indicating progress in its evaluation for safety and efficacy. Further research and clinical trials will be necessary to determine the potential of PMC-309 as a therapeutic option for patients with solid tumors.

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