Synapse Simplified: How to Find Clotrimazole Information

Clotrimazole, a diminutive molecule of pharmacological relevance, exerts its influence as an astoundingly powerful CYP51A1 inhibitor. This enzyme, paramount in the biosynthesis of ergosterol, a fundamental building block of fungal cell membranes, is the key target for clotrimazole's inhibitory prowess. Through its blockade of this enzyme, clotrimazole elicits a destructive effect on the integrity of fungal cell membranes, ultimately leading to their demise. The manifold fungal infections for which clotrimazole is primarily utilized as a treatment modality are tinea corporis, tinea cruris, tinea pedis, tinea, candidiasis, and tinea versicolor, amongst others. Initially developed and marketed by Bayer Vital GmbH and Schering-Plough Corp., this highly efficacious drug is presently manufactured and vended by Bayer Pharma AG. Since its first approval in 1981, clotrimazole has established itself as a widely employed antifungal agent, attaining this status on account of its superlative potency and exceptional safety profile, with an exceedingly low incidence of adverse effects. Click on the image below to begin the exploration journey of Clotrimazole through the Synapse database!

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