What is Disease Control Rate (DCR) in clinical trials?

Definition

This refers to the proportion of patients who, according to internationally recognized criteria for alleviating evaluation, achieve tumor relief (PR+CR) and stable disease (SD) after treatment and can maintain for the minimum duration requirement.

Positioning/Pros & Cons

Equivalent to Objective Response Rate (ORR)

The clinical research significance of Disease Control Rate (DCR) and Objective Response Rate (ORR) are generally the same, the difference between them is that: Disease Control Rate (DCR) includes patients with tumor maintained at SD (Stable), i.e., DCR = CR+PR+SD; ORR = CR+PR. The ability of a tumor to be controlled at SD (Stable) for a long time is also one of the effective performances of drug treatment. For drugs that benefit patients clinically by stabilizing the disease, the Disease Control Rate (DCR) can also be analyzed.