Hantavirus Infections

Vancouver, British Columbia--(News - September 18, 2023) - Biocure Technology Inc. (CSE: CURE) ("CURE" or the "Company") announces that it has entered into an exclusive letter agreement dated September 8, 2023 with Atriva Therapeutics GmbH. ("Atriva") whereby the Company will acquire all of the issued and outstanding securities of Atriva (the "Transaction"). The Transaction will be a business combination completed by way of a share exchange, share purchase, amalgamation, arrangement, takeover bid, or other similar form of transaction. Upon the successful completion of the proposed Transaction, it is anticipated that the Company will carry on the business of Atriva (the "Resulting Issuer"). The Transaction constitutes a 'reverse takeover' of the Company. Transaction Summary Pursuant to the Transaction, the Company will issue common shares in its capital ("CURE Shares") to the shareholders in the capital of Atriva ("Atriva Shares") on the basis of a proposed exchange ratio such that, following the closing of the Transaction, on a fully diluted basis, approximately 75% of the securities of the Resulting Issuer will be held by current Atriva securityholders, together with subscribers in a concurrent financing, and approximately 25% of the securities of the Resulting Issuer will be held by current CURE shareholders. No advances to be made by the Company to Atriva are contemplated by the letter agreement. Atriva has agreed to pay to CURE a fee of $15,000 per month as an exclusivity fee pending completion of the Transaction for a minimum period of three months. A finder's fees of US$2,000,000 is payable in connection with the Transaction, to be paid through the issuance of CURE Shares at a deemed price to be determined by the parties but having regard for the terms of a concurrent private placement. The Transaction is subject to a number of terms and conditions, including, but not limited to, the completion of satisfactory due diligence, the parties entering into a definitive agreement with respect to the Transaction on or before 30 November, 2023 (such agreement to include representations, warranties, conditions and covenants typical for a transaction of this nature), the completion of a private placement by Atriva or CURE to raise gross proceeds of at least US$15,000,000 as further described below, the approval of the shareholders of the Company and Atriva, and the approval of the CSE and other applicable regulatory authorities. All dollar figures referenced herein, unless otherwise specified, refer to Canadian dollars. Trading Halt Trading in the CURE Shares has been halted and is expected to remain halted pending the satisfaction of the listing requirements of the CSE. There can be no assurance that trading of CURE shares will resume prior to the completion of the Transaction. Further details concerning the Transaction (including additional financial information) and other matters will be announced if and when a definitive agreement is reached. Information Concerning Atriva Atriva is incorporated under the laws of Germany and is a biopharmaceutical company developing host-cell-targeting antiviral and immunomodulatory therapies. The company was set up by a team of leading scientists in viral disease research and industry experts. Atriva aims to develop novel, highly efficacious and safe therapies for the treatment of severe diseases caused by RNA-viruses with a high unmet medical need and huge cost burden to healthcare systems around the world such as influenza, respiratory syncytial virus infections, dengue fever and hanta virus infections. Atriva's lead product zapnometinib (previously known as ATR-002) is a novel, host-cell-targeting, orally available small molecule drug inhibiting viral replication and rebalancing the body's immune response. Zapnometinib has successfully completed two Phase I clinical trials to demonstrate safety and tolerability in healthy volunteers (NCT04385420 and NCT05555823). A Phase II study (NCT04776044) to evaluate the efficacy and safety of zapnometinib in hospitalized patients with severe COVID-19 obtained approval from Germany`s regulatory authority (BfArM) and generated very promising results. They underpin zapnometinib`s mechanism of action, efficacy against RNA-based virus infections and the safe use in humans. Going forward, Atriva will primarily focus resources on the development of zapnometinib for the treatment of patients hospitalized with severe influenza infections. Due to its mechanism of action with dual benefit - antiviral activity combined with immunomodulation - zapnometinib is uniquely positioned as a highly promising therapeutic candidate for the treatment of severe RNA-virus infections. By treating severe viral infections, Atriva strives to significantly reduce the number of critically sick patients, which would otherwise be referred to ICUs and require more invasive and vastly more expensive treatment options. Consequently, zapnometinib bears the potential to fundamentally improve the outcome of severe virus infections resulting in massive savings for entire societies and their national health care systems. Since inception, Atriva has secured over EUR 40 million in debt and equity investments from various investors and institutions including the European Investment Bank. Further details concerning the Transaction (including additional financial and shareholder information regarding Atriva) and other matters will be announced if and when a definitive agreement is reached. Board of Directors of Resulting Issuer Upon completion of the Transaction, the board of the Resulting Issuer shall be reconstituted to consist of a number of directors, the majority of which will be nominated by Atriva. Details regarding the anticipated directors and officers of the Resulting Issuer will be included in a subsequent release Private Placement Pursuant to the letter agreement, it is a condition of the Transaction that Atriva or CURE complete a private placement for aggregate gross proceeds of at least US$15,000,000 on terms to be determined. Additional details concerning the terms of the private placement will be provided in a subsequent press release. The Resulting Issuer intends to use the net proceeds of the private placement to fund the Transaction, to develop its business and for working capital. This news release does not constitute an offer to sell and is not a solicitation of an offer to buy any securities in the United States. The securities of the Company and BCBC have not been and will not be registered under the United States Securities Act of 1933, as amended (the "U.S. Securities Act") or any state securities laws and may not be offered or sold within the United States or to U.S. Persons unless registered under the U.S. Securities Act and applicable state securities laws unless pursuant to an exemption from such registration. Shareholder Meeting Approval for the Transaction will be sought from the Company's shareholders on a date to be determined. Name Change Upon completion of the Transaction, the Company intends to change its name to "Atriva Therapeutics Inc." and the parties expect that the CSE will assign a new trading symbol for the Resulting Issuer. Shares for Debt As an additional re-organizational step for the Transaction, the Company plans to settle approximately $500,000 in debt owed to various parties through the issuance of common shares of the Company at a price of $0.03 per share (the "Settlement Shares"), subject to the approval of the CSE. Portions of the indebtedness are expected to be settled with members of the Company's management team and will constitute a "related party transaction" as defined in MI 61-101. The Settlement Shares will be subject to applicable resale restrictions under securities laws. Corporate Update The Company also reports that Bjorn Cocholovius has resigned from his role as President. The Company wishes Mr. Cocholovius well in his other endeavors. Forward-Looking Statements This news release contains certain "forward looking statements" including, for example, statements relating to the completion of the Transaction and Private Placement and the Resulting Issuer's anticipated share capital. Such forward-looking statements involve risks and uncertainties, both known and unknown. The results or events depicted in these forward-looking statements may differ materially from actual results or events. In addition to other factors and assumptions which may be identified herein, assumptions have been made regarding and are implicit in, among other things: receipt of regulatory approvals, the Company's ability to complete the Transaction and Private Placement, the state of the capital markets, the ability of the Resulting Issuer to successfully manage the risks inherent in pursuing business opportunities in the cannabis industry, and the ability of the Resulting Issuer to obtain qualified staff, equipment and services in a timely and cost efficient manner to develop its business. Any forward-looking statement reflects information available to the Company as of the date of this news release and, except as may be required by applicable securities laws, the Company disclaims any intent or obligation to update any forward-looking statement, whether as a result of new information, future events or results or otherwise. ON BEHALF OF THE BOARD OF DIRECTORS /S/ "Simon Cheng" CEO and Director For further information, please contact: Biocure Technology Inc. Telephone: 604-609-7146, or info@biocuretech.com Neither the Canadian Securities Exchange (the "CSE") nor the Investment Industry Regulatory Organization of Canada) accepts responsibility for the adequacy or accuracy of this release. Completion of the Transaction is subject to a number of conditions, including stock exchange acceptance and shareholder approval. The Transaction cannot close until the required shareholder approval is obtained. There can be no assurance that the Transaction will be completed as proposed or at all. Investors are cautioned that, except as disclosed in the Information Circular and Listing Statement to be prepared in connection with the Transaction, any information released or received with respect to the Transaction may not be accurate or complete and should not be relied upon. Trading in the securities of the Company should be considered highly speculative. The Canadian Securities Exchange has in no way passed upon the merits of the proposed transaction and has neither approved nor disapproved the contents of this press release To view the source version of this press release, please visit

GOLDEN, Colo.--( BUSINESS WIRE )--In a review article 1 recently published in Vaccines Journal (MDPI) , Dr. Carmen Ledesma-Feliciano, Scientific Affairs Manager at PharmaJet, referencing over 25 studies, discusses multiple injection delivery methods including PharmaJet’s needle-free precision delivery systems, which enhance the clinical performance of DNA-based vaccines. The COVID-19 pandemic increased visibility of nucleic acid vaccines, such as messenger RNA (mRNA), that provide scalability and can be quickly adapted as new variants appear. DNA vaccines are also nucleic acid vaccines. Currently, 250 vaccine programs 2 are invested in DNA vaccines and therapeutics because of their potential benefits. DNA vaccines have inherent advantages compared to other vaccine types, including safety, rapid design and construction, ease and speed to manufacture, and thermostability. However, a major drawback of candidate DNA vaccines delivered by needle-syringe is the inadequate immunogenicity associated with inefficient cellular uptake of the DNA. Multiple techniques have been employed to boost the immunogenicity and protective efficacy of DNA vaccines including physical, electrical, and chemical delivery methods, molecular and traditional adjuvants, and genetic sequence enhancements. Historical limitations can be addressed with new administration technologies such as modern needle-free precision delivery systems. In studies comparing the PharmaJet precision delivery devices with traditional needle-syringe, Tropis ® and Stratis ® provided a wider dispersion pattern of the injectate within tissues and more efficient delivery into cells in the case of DNA vaccines. “Delivery of our vaccines with the Stratis device generated better antibody responses as compared to needle-syringe injection. In addition, we found Stratis easier to use, and we observed less discomfort to the laboratory animals,” noted Dr. Ros Chapman, Senior Research Officer, Institute of Infectious Disease and Molecular Medicine, University of Cape Town. In 2021, PharmaJet’s Tropis was selected as the exclusive delivery system for the first DNA vaccine approved for administration in humans when Zydus Lifesciences obtained Emergency Use Authorization approval from the Drug Controller General of India for its COVID-19 vaccine, ZyCoV-D. Zydus chose Tropis over traditional delivery methods based on pre-clinical and clinical study results that indicated Tropis increased the effectiveness of their vaccine compared to needle-syringe. Several DNA candidate vaccines in combination with PharmaJet devices are in development including for a COVID-19 bivalent booster 3 , HIV, Zika, influenza, poxvirus, hantavirus, and dengue infections. “We are enthused to see that pre-clinical results have translated into more effective clinical responses in human trials,” said Chris Cappello, President and CEO of PharmaJet. “We currently have eighty-three studies ongoing with novel pharmaceuticals focusing on nucleic acid technology in addition to other new vaccine technology platforms. We believe that our precision delivery devices have the potential to increase the performance and therefore probability of regulatory success of many of these candidate vaccines.” For more information about PharmaJet visit https://pharmajet.com . Refer to Instructions for Use to ensure safe injections and to review risks. 1 Improved DNA Vaccine Delivery with Needle-Free Injection Systems 2 Data on file 3 Scancell announces positive response in Covidity trial About PharmaJet PharmaJet’s vision is to enable greater access to life-saving vaccines and pharmaceuticals globally. We are committed to helping our partners realize their research and commercialization goals while making an impact on public health. PharmaJet Needle-free precision delivery devices provide increased vaccine effectiveness, a preferred patient and caregiver experience, and a proven path to commercialization. They are also safe, fast, and easy-to-use. The Stratis ® System has U.S. FDA 510(k) marketing clearance, CE Mark, and WHO PQS certification to deliver medications and vaccines either intramuscularly or subcutaneously. The Tropis ® System has CE Mark and WHO PQS certification for intradermal injections. They are both commercially available for global immunization programs. For more information visit https://pharmajet.com . Follow us on LinkedIn .

Atriva Therapeutics GmbH announces high-level results from the Phase 2a RESPIRE study Results indicate a clinically relevant efficacy pro zapnometinib, in terms of the primary endpoint, clinical severity status (CSS) at Day 15, with a favorable safety pro > Atriva decided to terminate the study early, the decision was based on low recruitment projection as well as the high prevalence of patients infected with the Omicron variant, resulting in fewer hospitalizations Results from RESPIRE provide proof of concept for the clinical benefit of zapnometinib Atriva has a clear path for the further clinical development of zapnometinib in severe Influenza, COVID-19, and respiratory syncytial virus (RSV) (PanTher Study planned for Q1/23), as well as in other severe viral diseases Atriva will report on a detailed analysis of the safety and efficacy data in due course Tübingen and Frankfurt, Germany, September 20, 2022 – Atriva Therapeutics GmbH, a biopharmaceutical company that is pioneering the development of host-targeting antiviral therapies, announced today the topline findings from the Proof on Concept (POC) / Phase 2a RESPIRE study (zapnometinib) in patients hospitalized with moderate-to-severe COVID-19. RESPIRE planned to include 220 patients, however, due to recruitment challenges arising from the lower frequency of COVID-19 hospitalizations caused by the Omicron variant compared with previous variants, Atriva Therapeutics GmbH have decided to terminate the study with 104 evaluable patients. Patients enrolled in RESPIRE were well balanced between groups, with 40% of patients requiring supplemental oxygen in the zapnometinib arm and 41% requiring supplemental oxygen in the placebo arm. A clinically relevant trend for improvement was observed, including the primary endpoint of clinical severity status (CSS) on Day 15 (Odds Ratio (OR) [95% confidence interval] 1.54 [0.72–3.33]). The primary endpoint addresses both efficacy and safety, as the CSS ranges from death as the most severe category to hospital discharge, with and without limitations of activities, as the most favorable categories. Sensitivity and subgroup analyses were defined a priori, including subgroup analysis by the randomization strata of disease severity at baseline (CSS levels 3 or 4). Results from both the primary (improvement on the World Health Organization CSS scale) and key secondary (time to hospital discharge) endpoints in RESPIRE indicate a clear benefit amongst patients with more severe disease activity (CSS 4), confirming the mechanism of action of zapnometinib. In the subgroup of patients with CSS 4 at baseline, a clinically relevant Odds Ratio greater than 2 was observed for the primary endpoint. In addition, in subgroup analyses for the key secondary endpoint, patients infected with the Delta variant of SARS-CoV-2 had significantly better outcomes compared to those infected with the Omicron variant. Safety data from RESPIRE indicate a favorable profile, with a balanced incidence of treatment-emergent adverse events (TEAEs) between study groups. There was no indication of drug-induced liver injury (DILI), and no cardiac arrhythmia. These data provide proof of concept for the clinical benefit of zapnometinib in patients with severe COVID-19 and support further evaluation of zapnometinib in influenza, COVID-19, and other severe viral diseases. Atriva and investigators are continuing to evaluate the RESPIRE data and will provide an update on the full dataset in due course as well as next steps for the program. Prof. Gernot Rohde, M.D., Head of Pneumology and Professor for Respiratory Medicine and Allergology at the Goethe University Hospital, Frankfurt am Main, Germany, (Global Coordinating Investigator RESPIRE) comments: “Despite recent approvals of treatments for patients with severe COVID-19, there remains a significant unmet medical need for targeted, effective therapies in severe viral respiratory infections. The data for zapnometinib from the RESPIRE Study are highly encouraging and suggest that the innovative approach of targeting the intracellular Raf/MEK/ERK signaling pathway may prove to be effective in treating such conditions.” Dr. Stephan Stenglein, CMO Atriva Therapeutics, adds: “We are pleased to see impressive data from our first clinical study (RESPIRE). The results we obtained show a strong trend for efficacy of zapnometinib in patients with severe COVID-19. In addition, from sensitivity analyses performed, we also have indications of a statistically significant and clinically relevant risk reduction in the subgroup of more severe patients in RESPIRE, along with a favorable safety profile. A detailed analysis of all study endpoints is currently ongoing. Atriva will now continue to develop zapnometinib in a pandemic preparedness Phase 2 study (PanTher) that will include patients with severe disease caused by influenza, SARS-CoV-2, or RSV.” Dr. Rainer Lichtenberger, CEO Atriva Therapeutics, concludes: “These very encouraging study results provide a perfect foundation for the company's further strategic positioning as a pioneer in delivering novel, broad-based and highly effective therapies against severe viral diseases with pandemic potential.” About the RESPIRE study RESPIRE[1] is a randomized, double-blind, placebo-controlled, international, multi-center POC (Proof of Concept) / Phase 2 clinical trial in adult patients with moderate-to-severe COVID-19. Hospitalized patients with or without supplemental oxygen at the time of screening or randomization were enrolled. On top of standard of care, patients were randomized to receive zapnometinib (ATR-002) 900 mg tablets, once daily on Day 1, followed by zapnometinib 600 mg once daily on Days 2 to 6, or to receive placebo in a matching scheme. The study is designed to establish the efficacy of zapnometinib; the primary endpoint is CSS on Day 15, using a seven-point ordinal scale as recommended by the WHO COVID-19 Therapeutic Trial Synopsis.[2] Secondary endpoints include time to hospital discharge, changes in clinical signs and symptoms and other relevant clinical parameters. All patients have been followed-up for 90 days. About zapnometinib The Atriva lead product zapnometinib (ATR-002) was specifically developed to treat diseases caused by RNA viruses, such as influenza and COVID-19. Zapnometinib is a MEK inhibitor targeting the intracellular Raf/MEK/ERK signaling pathway. Many RNA viruses need to activate this pathway to ensure replication, including influenza viruses,[3] hantaviruses,[4] the respiratory syncytial virus (RSV),4 and coronaviruses,4 including SARS-CoV-2. Zapnometinib inhibits cellular MEK (MAPK/ERK kinase), blocking the formation of functional virus particles in the host cell, ultimately reducing the viral load in the body.[5],[6] In SARS-CoV-2 infected cells, inhibition of MEK1/2 by zapnometinib significantly reduces virus production.[7] In addition, zapnometinib has the potential to modulate the host immune response and avoid an excessive cytokine/chemokine response that can be caused by viral infections.[8],[9] This second host-targeting effect may therefore mitigate the overactive inflammatory response, e.g., as seen in the lungs of patients who are severely ill with COVID‑19 or influenza.7,[10] In SARS-CoV-2 infected cells, inhibition of MEK1/2 by zapnometinib significantly impairs pro-inflammatory cytokine production.7 Zapnometinib is under advanced clinical development as a treatment for patients with influenza or COVID-19. For the treatment of hantavirus infections, zapnometinib has been granted Orphan Drug Designation (ODD) by the U.S. Food and Drug Administration (FDA). About Atriva Therapeutics Atriva Therapeutics’ mission is to develop an antiviral therapy platform against severe respiratory and systemic diseases with a high unmet medical need induced by RNA viruses, e.g., influenza and COVID-19. The clinical-stage biopharmaceutical company is pioneering the development of host-targeting antiviral therapies, making development of resistance unlikely, and thereby significantly contributing to pandemic preparedness. The Atriva lead product zapnometinib (ATR-002) is a first-in-class, host-targeting agent that aims to inhibit viral replication and to favorably modulate the body’s immune response to RNA viruses. Eleven patent families with broad international coverage grant protection for the use of MEK inhibitors and other kinase inhibitors for antiviral therapies through 2041. Atriva Therapeutics was founded in 2015 by a team of leading scientists in viral research and seasoned industry experts and is based in Tübingen and Frankfurt, Germany. Atriva is a founding member of the BEAT-COV initiative. For further information, please visit and follow us on LinkedIn and Twitter. Contact: Atriva Therapeutics GmbH Dr. Rainer Lichtenberger, CEO phone: +49 69 9999 162 10 mobile: +49 151 7443 3175 lichtenberger@atriva-therapeutics.com Media and Investor Relations: MC Services AG Eva Bauer / Raimund Gabriel phone: +49 89 210 228 80 atriva-therapeutics@mc-services.eu References [1] Atriva Therapeutics GmbH. 2022. A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Clinical Trial to Evaluate the Safety and Efficacy of ATR-002 in Adult Hospitalized Patients with COVID-19 (RESPIRE). [2] . [3] Pleschka S et al. Nat Cell Biol 2001 Feb 3:301-5. [4] Pleschka S. 2008. Biol Chem. 389, 1273–1282. [5] Haasbach E et al. Antiviral Res 2017 Jun 142:178-4. [6] Laure M et al. Antiviral Res 2020 Jun 178:104806. [7] Schreiber A et al. 2022. Cell Mol Life Sci. 79(1):65. [8] Planz O Antiviral Res 2013 Jun 98(3):457-68. [9] Pinto R et al. Antiviral Res 2011 Oct 92(1):45-56. [10] Ragab D et al. 2020. Front Immunol. 11, 1446 (2020).