Malignant neoplasm of large intestine

“A blood-based colorectal cancer screening test that can detect advanced precancerous lesions at a level comparable to the FIT test would be a breakthrough in this field,” said Paul Limburg, Exact Sciences’ chief medical officer for screening. As it works to diversify its methods for catching early cases of colorectal cancer, Exact Sciences has put forward clinical data showing its blood-based test can help spot growing tumors as well as some precancerous lesions.Presented at the annual meeting of the European Society for Medical Oncology, being held in Barcelona, Spain, the company said the latest findings may put its upcoming blood screener in the same realm as a fecal immunochemical test in the detection of those advanced polyps.The results came from Exact Sciences’ ongoing BLUE-C study—an expansive colorectal cancer trial of more than 26,000 people that has also examined the second generation of the company’s mainstay Cologuard screening test, which is currently under review at the FDA.Using more than 3,000 blood samples, the company said it has now finalized an algorithm that incorporates patterns in DNA methylation that can be traced back to cancer cells—as well as “an impactful, new marker class” for identifying patients with precancerous lesions.“This led to data that improve upon what we previously thought was possible with a blood-based colorectal cancer screening test,” CEO Kevin Conroy said in a statement. The trial delivered a sensitivity of 88.3% for malignant colorectal cancer and 31.2% for precancerous lesions, alongside a false-positive rate of 9.9% among participants who went on to have a colonoscopy.In BLUE-C’s head-to-head comparison of the next-gen Cologuard and a standard FIT exam—published earlier this year in the New England Journal of Medicine—FIT posted a sensitivity of 23.3% for advanced precancerous lesions, while Cologuard’s stool-based, multitarget DNA approach reached 43.4% in the same category.“A blood-based colorectal cancer screening test that can detect advanced precancerous lesions at a level comparable to the FIT test would be a breakthrough in this field,” said Paul Limburg, Exact Sciences’ chief medical officer for screening.“Results from this large, well-designed study show progress toward that goal and move us one step closer toward providing average-risk patients with another non-invasive screening option,” Limburg added.Elsewhere, a separate analysis of Guardant Health’s rival colorectal cancer screening blood test reported a sensitivity of 13.1% for advanced precancerous adenomas—a number that became a sticking point during the company’s May meeting with an FDA advisory committee, which would go on to endorse the test. Known as Shield, it received a groundbreaking approval from the agency in late July. Ahead of the ESMO presentation, Guardant Health co-founder and co-CEO AmirAli Talasaz said in a LinkedIn post over the weekend he would “publicly bet” Conroy $1 million that Exact Sciences’ preliminary data “won’t hold up” to its final pivotal trial readout.In its release, Exact Sciences said it expects the blood-based screening portion of the BLUE-C trial to hand in its full results in the first half of 2025, which would then be used to build a new product submission for the FDA. Cologuard Plus, meanwhile, has been slated for a commercial launch next year, pending the agency’s green light.Also at ESMO 2024, Exact Sciences presented data from its blood test designed to detect multiple cancers at once. Echoing findings shared earlier this year at the American Association for Cancer Research annual meeting, the test demonstrated 63.7% overall sensitivity among six of the most aggressive tumor types, including cancers of the esophagus, liver, lung, ovaries, pancreas and stomach.

LONDON , Oct. 9, 2023 /PRNewswire/ -- Colorectal Cancer often referred to as malignant colonic tumor, metastatic bowel cancer, metastatic colon carcinoma, or metastatic colorectal carcinoma, is a type of cancer that begins in the colon or rectum is a form of cancer occurring in the rectum or colon. It is an aggressive form of cancer that can rapidly spread to other parts of the digestive system. There has been an increased pervasiveness of this cancer equally affecting both men and women. Early detection in the form of colonoscopy screening plays a vital role in promoting fast prognosis. Drug development endeavours are also going on across various parts of the world with an aim to find a permanent cure for this ailment. The increased CRC disease burden has become a caused of concern for various nations. It is worth noting that colorectal cancer also known as metastatic rectal cancer usually begins as small, noncancerous growths called polyps on the inner lining of the colon or rectum. The growth of large polyp in colon takes the form of aggressive cancer if not diagnosed at an early stage. The colon is the large intestine, and the rectum is the last section of the colon, leading to the anus. Risk factors for colorectal cancer include age (the risk increases with age), a family history of the disease, certain genetic mutations, a diet high in red and processed meats, obesity, smoking, heavy alcohol consumption, and certain medical conditions such as inflammatory bowel disease (IBD). Price and Market Access The Market Competitors Listed Below are Revolutionizing Healthcare with Innovative Diagnostic Inventions: GI View Ltd Sun Pharmaceuticals Industries Ltd. Exact Sciences Corporation Becton, Dickinson, and Company DiagnoTech Corporation FUJIFILM Holdings America Corporation Cipla Ltd. QIAGEN MANCHESTER LTD Innovia Medical Gastro Diagnostics.Ltd KARL STORZ SE & Co. KG Thyrocare Technologies Epigenomics AG Cardinal Health Inc. Radiance Imaging System HUGER Medical Instrument Co., Ltd Apollo Diagnostics Roche Molecular Systems, Inc. Paramount Surgimed Limited UltraScan diagnostics Pro Scope Systems Fortis Healthcare Illumina, Inc. Integra LifeSciences Med Imaging Solutions MECAN MEDICAL EQUIPMENT CO LTD Epigenomics Ventana Medical Systems KAI Group Mindray Medical International Limited Others Learn More About the FDA NDA & BLA Approval (NME) Drugs for Colorectal Cancer @ DiseaseLandscape Insights has been offering healthcare consulting services to the players operating in this vertical. It is assisting them with clinical trial feasibility analysis, clinical trial management, price and market access, commercial strategy analysis, product portfolio extension, along with other pivotal activities. The industry participants are trying to strengthen their position in the CRC management landscape. Colorectal Cancer Disease Overview- Types, Causes, and Symptoms: Adenocarcinoma, Carcinoid Tumors, Gastrointestinal Stromal Tumors (GISTs), Lymphomas, and Sarcomas are the primary types of CRC. Although the exact causes behind its occurrence has not been known but genetic issues, age, unhealthy lifestyle, smoking, and alcohol intake, can be the triggering factors. The major symptoms are anemia, fatigue, weakness, blood in stool, changes in bowel habits, abdominal discomfort, and weight loss. Early detection can be life saving for patients. The diagnostic landscape of this disease is diverse wherein colonoscopy recommendations are given by doctors due to its accuracy. Colonoscopy screening age is typically 45 to 50 for average-risk individuals. Apart from that ct scan colon cancer and ct scan for bowel cancer, may also be suggested for the detection of colorectal malignant neoplasm. Effective treatment solutions are chemotherapy for colorectal cancer and radiation for rectal cancer. The latter uses high-energy radiation to target and destroy cancer cells in the rectum and can be administered alone or in combination with other treatments. Unlock the Benefits Today! Get Started Now and Elevate Your Experience @ Final Words: CRC is a highly prevalent forms of cancer affected a large part of the global population. It predominantly affects the digestive system specially the rectum, colon, and large intestine. Smoking, excessive alcohol intake, sedentary lifestyle, age, and family history, among others are known to be the factors leading to the onset of this ailment. DLI has been a support system for the players looking forward to transforming the CRC management. It has been assisting them with regulatory consulting, pharma consulting services, post launch strategies, product pipeline assessment, and treatment gaps identification. The sole aim of this health consultant and other players is to save the lives of the patients diagnosed with this devastating ailment. 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Obtain an epidemiology study and market access. Rely on DLI! FDA-EMA Approved Drugs, Disease Landscape, and Epidemiology Studies: Expert Consulting on Skin Cancer. Pricing Compensation and Market Access. Find out more about Tonsillitis symptoms, consulting services, drug costs, FDA-approved medications, disease landscape, regulatory insights, epidemiology, and price reimbursement. Investigate the epidemiology, prevention, and consulting services for Scrub Typhus. Discover the landscape of diseases, FDA-EMA approved medications, and more. Discover the market insights, competitive environment, regulatory updates, and epidemiology study for lymphoma. Market entry strategy: Unlock market intelligence. About Disease Landscape:  Disease Landscape, a pioneering company specializing in Disease Intelligence, Pricing, and Market Access. Utilizing the power of data analytics, Disease Landscape Insights is dedicated to healthcare sector with invaluable, finely crafted insights and recommendations regarding global pricing and market access strategies. As a specialized firm, we are committed to delivering unparalleled insights into pricing and market access, custom-tailored to the healthcare and pharmaceutical industries. Our data-driven solutions and cutting-edge technology position us as your trustworthy partner, offering swift, adaptable, and evidence-based alternatives to traditional market access and pricing research methods.  Our core competencies encompass Market Research Services, Consulting Services, Global Pricing and Market Access, Epidemiology Studies, as well as Product Portfolio and Pipeline Services. 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Top hospital in Tucson joins Medicare Advantage company’s provider network, elevating senior care for members in Pima, Santa Cruz countiesTUCSON, Ariz. and ORANGE, Calif., July 05, 2023 (GLOBE NEWSWIRE) -- Alignment Health Plan, the award-winning Medicare Advantage plan from Alignment Health, today announced it is expanding access to quality health care and services for its members in Pima and Santa Cruz counties through a new agreement with Tucson Medical Center (TMC). Effective July 1, the agreement will provide Alignment’s Arizona plan members access to approximately 165 providers and TMC services. “By partnering with Tucson Medical Center, our members gain access to more top primary care providers and specialists who share our passion for transforming the lives of seniors,” said Dan Peterson, Arizona market president at Alignment Health. “It’s important to our mission to tap into respected community partners to help seniors live their best lives as we usher in a new era of aging. We’re excited to team up with TMC to provide more care options for the members we serve in Pima and Santa Cruz.” Tucson Medical Center has cared for its community since 1944, serving as Tucson’s locally governed, nonprofit regional hospital for more than 75 years. It was ranked by U.S. News & World Report as the No. 1 hospital in the Tucson metro area for two consecutive years, No. 4 in the state last year and No. 1 in Tucson for pulmonology, nephrology, diabetes, colon cancer surgery, hip replacement and knee replacement for 2022-2023. With more than 600 beds, it is the second-largest hospital in Southern Arizona. Arizona members enrolled in Alignment’s PPO and HMO plans, including its chronic special needs plan for individuals with heart disease or diabetes, will have access to all TMC services, including emergency care, intensive care, cardiac care, orthopedic, neuroscience, hospice, surgical, vascular, geropsychiatric care and more, as well as TMC One, which provides primary and specialty care via a dedicated team of more than 60 primary care providers and dozens of specialists. About Alignment HealthAlignment Health is championing a new path in senior care that empowers members to age well and live their most vibrant lives. A consumer brand name of Alignment Healthcare (NASDAQ: ALHC), Alignment Health is a tech-enabled Medicare Advantage company that offers more than 40 benefits-rich, value-driven plans that serve 52 counties across six states. The company partners with nationally recognized and trusted local providers to deliver coordinated care, powered by its customized care model, 24/7 concierge care team and purpose-built technology, AVAⓇ. Based in California, the company’s mission-focused team makes high-quality, low-cost care a reality for members every day. As it expands its offerings and grows its national footprint, Alignment upholds its core values of leading with a serving heart and putting the senior first. For more information, visit www.alignmenthealth.com. Media ContactPriya ShahmPR, Inc. for Alignment Healthalignment@mpublicrelations.com