Bronchiolo-Alveolar Adenocarcinoma

SEATTLE, May 11, 2023 /PRNewswire/ -- Physician-Scientist Dr. Steven Quay, MD, PhD has provided a set of recommendations to the United States Preventive Services Task Force (USPSTF) following the publication of their draft report on breast cancer screening. The draft recommendations were made available for public comment on May 9, 2023 and can be found here: Breast Cancer: Screening. In the draft recommendations, the USPSTF calls for mammograms to begin at 40 years of age, returning to their pre-2009 recommendation. In 2009, in a decision that was met with controversy in the medical community, the USPSTF said that women could wait until they were age 50 before beginning screening for breast cancer. Dr. Quay has spent the last decade conducting research on breast cancer, including its prevention, and has 71 patents and patent applications related to his work. "I appreciate that the USPSTF has brought their recommendation in line with decades of data and back to their 2009 recommendation of starting at age 40, agreeing with the medical community of the benefits of starting screening early," stated Dr. Quay, MD, Ph.D., President and CEO of Atossa Therapeutics, Inc. (NASDAQ: ATOS), a clinical-stage biopharmaceutical company with a focus on breast cancer. "However, for 14 years women in their forties have been left to fend for themselves. I believe that the shift in recommendation from age 40 to 50 in 2009 may have led to thousands of early breast cancer diagnoses being missed as a consequence. And the toll is heaviest in those women without access to quality healthcare, including women of color." Dr. Quay's comments to the USPSTF consist of three recommendations: Women who are at normal risk of breast cancer should begin mammographic screening at age 40. If they have risk factors that identify them as high risk, using validated risk assessment tools like the "Gail Model," their first mammogram should be at age 35. Breast cancer for women in their 40s has an incidence of 150 to 200 cases per 100,000 population. That translates into 30,000 to 40,000 cancers that were missed with the previous recommendations of beginning at age 50. Given that the compliance of mammography screening with respect to guidelines is only 75%, the USPSTF should consider recommendations that link government-based healthcare reimbursement to programs and outcomes that lead to improved compliance. High breast density is a known, modifiable risk factor for future breast cancer as well as reducing the sensitivity of mammography for breast cancer detection. The FDA has now required that all mammography reports sent to women beginning in the fall of 2023 contain information about breast density, and its impact on sensitivity and cancer risk. The USPSTF should consider two density related matters: they should consider recommending additional imaging, either ultrasound or MRI, for women with high breast density; and they should consider providing a report on the strength of the evidence of the relationship of density, mammographic sensitivity to cancer detection, and future cancer risk. This report should also include an analysis of the evidence that certain factors can reduce breast density, including lifestyle changes, diet, and pharmaceutical interventions. For example, clinical trials of the effect of Z-endoxifen on breast density are being conducted by Atossa Therapeutics, Inc. and data will be forthcoming. While the mortality of breast cancer makes it the most frequent cancer-related death in women, cardiovascular disease remains the number one killer of women. Recent developments in the detection of breast artery calcification (BAC) in routine mammograms and its value in predicting women at high risk of cardiovascular disease and its sequelae has been impressive. The USPSTF should consider examining the evidence of the utility of this ancillary data from screening mammograms and determine if recommendations for its use to help stratify women at risk of cardiovascular disease is warranted. ABOUT STEVEN QUAY, MD, PHD Dr. Steven Quay has 390+ published contributions to medicine and has been cited over 11,500 times, placing him in the top 1% of scientists worldwide. He holds 88 US patents and has invented seven FDA-approved pharmaceuticals which have helped over 80 million people. He is the author of the best-selling book on surviving the pandemic, Stay Safe: A Physician's Guide to Survive Coronavirus. He is the CEO of Atossa Therapeutics Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company developing novel therapeutics for oncology, including his patented Z-endoxifen for breast cancer and other conditions. He received his M.D. and Ph.D. from The University of Michigan, was a postdoctoral fellow in the Chemistry Department at MIT with Nobel Laureate H. Gobind Khorana, a resident at the Harvard-MGH Hospital, and spent almost a decade on the faculty of Stanford University School of Medicine. A TEDx talk he delivered on breast cancer prevention has been viewed over 220,000 times. For more information, visit Public Relations Contact: Dunn Pellier Media| t: 323.481.2307 11620 Wilshire Blvd., 9th Floor, Los Angeles, CA 90025 [email protected] [email protected] SOURCE Dr. Steven Quay

BAC Detected by Digital Mammography Are a Potential Marker of Coronary Artery Disease CHICAGO, Nov. 28, 2022 /PRNewswire/ -- Ikonopedia, a leading developer of an innovative cloud-based structured breast reporting and MQSA (Mammography Quality Standards Act) management system, announced a study, published this month in the Annals of Epidemiology using the company's powerful analytical solutions, demonstrate age can be a significant risk factor for breast arterial calcifications (BAC). The retrospective study involved the review and analysis of more than 17,000 digital mammography patient records. The company is showcasing the analytical tools used in the study at the annual Radiological Society of North America (RSNA) conference being held November 27-30, 2022 in Chicago. Continue Reading "This groundbreaking study indicates the risk of BAC doubles for every 10 years of age," said Emily Crane, president and CEO of Ikonopedia. "BAC detected by digital mammography are a potential marker of coronary artery disease (CAD). This may portend that communication of BAC information in clinical settings could potentially prompt women to engage in preventive care for CAD." Using comprehensive analytics, such as those enabled by Ikonopedia, the assessment of BAC would add minimal exam time Tweet this The study found BAC prevalence was 12.3 percent overall. Age-adjusted analyses also showed higher BAC prevalence among Hispanic and Black women. It also indicated lower BAC prevalence among Ashkenazi women, nulliparous (never given birth to a child) and pre-menopausal women, those with dense breasts and breast implants, and those currently using hormone replacement therapy (HRT). Ikonopedia's platform includes the Insight Analytics tool, which provides comprehensive end-to-end reporting and deep mining analytic capabilities. These analytics help identify the types of cancer, breast tissue density, compliance and other high risk indicators by age group to help assist in managing patient populations. "The study concluded that annual mammograms have the potential to serve a dual function – screening for both breast cancer and BAC," said Crane. "This dual function could be carried out without additional radiation or prolonging the patient's mammogram appointment. Using comprehensive analytics, such as those enabled by Ikonopedia, the assessment of BAC would add minimal time to the interpretation and reporting tasks of the breast radiologist while triggering preventative care in a more timely matter." The company is also highlighting its newest software upgrade including the company's recently introduced Insight Analytics tool, which provides comprehensive end-to-end reporting and deep mining analytic capabilities within the Ikonopedia solution. These analytics help identify the types of cancer, breast tissue density, compliance and other high risk indicators by age group to help assist in managing patient populations. About Ikonopedia Ikonopedia was founded by three expert breast imaging Radiologists: László Tabár, MD is the author of 6 books in 10 languages on mammography and a world-renowned educator; A. Thomas Stavros, MD is the author of one of the most popular reference books in the field of breast ultrasound; and Michael J. Vendrell, MD is an expert in breast MRI and CAD design with extensive experience in breast-imaging software. For more information, visit . SOURCE Ikonopedia