Synonyms LGMD, Leyden-Mobius muscular dystrophy, Limb Girdle Muscular Dystrophies + [43] |
Introduction A heterogenous group of inherited muscular dystrophy that can be autosomal dominant or autosomal recessive. There are many forms (called LGMDs) involving genes encoding muscle membrane proteins such as the sarcoglycan (SARCOGLYCANS) complex that interacts with DYSTROPHIN. The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles). |
Target |
Mechanism IgG inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. EU [+3] |
First Approval Date25 Aug 2020 |
Target |
Mechanism GR agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. IT |
First Approval Date01 Jan 1985 |
Target- |
Mechanism- |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date09 Apr 1964 |
Start Date01 Jul 2024 |
Sponsor / Collaborator |
Start Date01 May 2024 |
Sponsor / Collaborator ![]() |
Start Date01 Apr 2024 |
Sponsor / Collaborator ![]() |