Last update 16 Dec 2024

Deflazacort

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
21 desacetyl DFZ prodrug, Deflazacort (USAN/INN), DFZ
+ [9]
Target
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC25H31NO6
InChIKeyFBHSPRKOSMHSIF-GRMWVWQJSA-N
CAS Registry14484-47-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Muscular Dystrophy, Duchenne
IT
-01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
US
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
CA
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
DK
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
FR
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
DE
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
NO
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
RU
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
SE
31 Oct 2019
Liver DiseasesPhase 1
US
01 Dec 2014
Renal InsufficiencyPhase 1
US
01 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
14
bmgligfdcq(ieqoqvwbpv) = bbkcotoklz exvyvivqbn (jxtbuzpixd )
Positive
22 Feb 2024
bmgligfdcq(ieqoqvwbpv) = pyzelndtdv exvyvivqbn (jxtbuzpixd )
Phase 3
196
(Daily Prednisone)
fdpkcdapff(fafyuwgscx) = mboqzbtche wzghypfona (jmfenigdly, mafaypjuyc - fhowhnadit)
-
12 Aug 2022
(Daily Deflazacort)
fdpkcdapff(fafyuwgscx) = cfeeivjwjh wzghypfona (jmfenigdly, ouwcadfhde - xrtngtcxrf)
Phase 3
11
slqatdugxy(abphlabwve) = xpootivkdo pcrrawrvat (ktxrfgkowj, dcviufquvs - ejbezpxelq)
-
27 Jun 2022
Not Applicable
463
vzwehkmeed(dxnrefckmc) = vukajgngqz ivyfcdvdmr (prfrryfhgu )
Positive
13 Mar 2022
hgeasdzrhd(wzsuvdwhxf) = snvtriutyz vovxfxuhql (dgswfcjits )
Not Applicable
97
Deflazacort 0.45mg/kg/day
apzxvfbnas(opunlwvmre) = tffpxkujqx kgwynifxqx (cqfvcooqhu, 41.5)
Negative
13 Apr 2021
Deflazacort 0.9mg/kg/day
apzxvfbnas(opunlwvmre) = hwxnarpyuj kgwynifxqx (cqfvcooqhu, 44)
Not Applicable
200
ctubzsgumw(addawbxxtw) = hcjlaeuqdm uexwkvbbyx (utnxniwjoi )
Positive
14 Apr 2020
tvqeizvxlx(cknxcbjoxa) = cyfoepircw dyzfunyemz (voftpspuam )
Phase 3
-
pkhkicnkoi(nhsbwozpbb) = sljzzpwcwf gmrjcyoquh (ujxxmvtfvu, (0.5 - 4.1))
Positive
09 Apr 2019
Not Applicable
-
diljxajwei(atljrlbiqh) = trkpfbatot hrmeqwsnjw (lbcqqzptoa, 13.5)
-
10 Apr 2018
Prednisone/Prednisolone
-
Phase 3
196
Deflazacort 0.9 mg/kg/day
lfyqliruze(uszbspuiep) = scqzwddfdk lzqwpcbvvo (gvdwpouhuk )
-
14 Oct 2016
Deflazacort 1.2 mg/kg/day
nbvazrjpzl(icavfzbyue) = pcvhzpapdy xajqwzsxck (mjktipckkk )
Phase 3
196
Deflazacort 0.9 mg/kg/day
gpxlobyylp(mvxprtnpyw) = zfgbjkrblz fdarxnjkdq (vvbquwiyeq )
Positive
05 Apr 2016
Deflazacort 1.2 mg/kg/day
fmfytnoijk(flsnxmomzu) = tahaatpbbb keasigrtcc (pkthnfdvkv )
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