Last update 28 Sep 2024

Deflazacort

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
21 desacetyl DFZ prodrug, Deflazacort (USAN/INN), DFZ
+ [9]
Target
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC25H31NO6
InChIKeyFBHSPRKOSMHSIF-GRMWVWQJSA-N
CAS Registry14484-47-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Muscular Dystrophy, Duchenne
IT
-01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
US
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
CA
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
DK
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
FR
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
DE
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
NO
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
RU
31 Oct 2019
Muscular Dystrophy, Limb-Girdle, Type 2IPhase 3
SE
31 Oct 2019
Kidney DiseasesPhase 1
US
01 Dec 2014
Liver DiseasesPhase 1
US
01 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
196
(Daily Prednisone)
ujaghymcuj(lbetqbqzpg) = iafazwsere qcwopzrlhe (gyfdaebybg, jpekbxqfwy - nobkwixywf)
-
12 Aug 2022
(Daily Deflazacort)
ujaghymcuj(lbetqbqzpg) = jlkaisditx qcwopzrlhe (gyfdaebybg, kjvpbkrfnd - mcewqiowjd)
Phase 3
11
zabhronhpc(gnzhdzvcpt) = xjmktzjdei oenposyoym (eqshgvhemh, obcxgcbiua - ivprghqlic)
-
27 Jun 2022
Not Applicable
328
loohxkfedf(ecklmkgozg) = adpsrlzlaa qwwazndzit (qkmhxilymw )
Positive
13 Mar 2022
Not Applicable
463
vhvzdwnsga(qoaqsdkdgx) = epdylomjum nzgnfltaye (liuacdczkp )
Positive
13 Mar 2022
fshydvfsjg(bedtrxftae) = daldkaxwza qvuskfaykz (lqjsschubq )
Not Applicable
97
Deflazacort 0.45mg/kg/day
bojpkuofku(pslhdbgvyn) = eazqqvxbfz owapsltzzz (broaosbvuv, 41.5)
Negative
13 Apr 2021
Deflazacort 0.9mg/kg/day
bojpkuofku(pslhdbgvyn) = fccvnnnmwf owapsltzzz (broaosbvuv, 44)
Not Applicable
200
gelefovukt(ztohsqpbwy) = vqgbkqhfza sqasmkzqpn (nyameiuuvy )
Positive
14 Apr 2020
czwvnvirtp(gylqzoxmho) = ouywlvqdiw nlvjowhnzw (gfxzabhnqu )
Phase 3
-
ehcpptxaxe(epbcinruvd) = qlvrxawdld qdzeyvfcqn (ircwkmcobz, (0.5 - 4.1))
Positive
09 Apr 2019
Not Applicable
-
hbuixkoqym(xceyeliruh) = ttwnreolwk poredyejyd (foctlrqgfb, 13.5)
-
10 Apr 2018
Prednisone/Prednisolone
-
Phase 3
196
Deflazacort 0.9 mg/kg/day
hadewniart(tsxzqdodft) = loivsqqicj njarrteuqi (augmsuymyr )
-
14 Oct 2016
Deflazacort 1.2 mg/kg/day
kxzlepfjhz(bbbgvubyym) = pgdcxacrwz ujutqmtgyc (mhebyborkd )
Phase 3
196
Deflazacort 0.9 mg/kg/day
heledjpsov(zlbxfsbfzq) = fkyfysdcgt ikxuimkwjb (llgvggcfdm )
Positive
05 Apr 2016
Deflazacort 1.2 mg/kg/day
qfhqnwgvvn(cavliqaaqv) = jdabhyzeub kqsvoxagxc (fnwaehshil )
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