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Last update 08 May 2025

Ground glass lung nodule

Last update 08 May 2025

Basic Info

Synonyms

Ground glass lung nodule, 肺すりガラス状結節, ﾊｲｽﾘｶﾞﾗｽｼﾞｮｳｹｯｾﾂ

Introduction-

Drugs associated with Ground glass lung nodule

Autologous NK cells(Shanghai OriginCell Biotech)

Target-

Mechanism

Immunologic cytotoxicity

Active Org.-

Originator Org.

Shanghai Yuantian Biotechnology Co., Ltd.

Active Indication-

Inactive Indication

Ground glass lung nodule

Drug Highest PhaseSuspended

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Ground glass lung nodule

NCT06394037

/ Not yet recruitingNot ApplicableIIT

Active Surveillance for Patients with Limited Ground-glass Nodules in China: a Prospective Multi-center Single-arm Trial (ECTOP-1028)

This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) . The primary objective of the study is to assess the 5-year overall survival of patients with one or two ground-glass opacities by employing an active surveillance approach rather than immediate surgical resection.

Start Date01 May 2025

Sponsor / Collaborator

Fudan University

NCT06848881

/ Not yet recruitingNot ApplicableIIT

Cryoablation Versus Thoracoscopic Surgery for Pulmonary Ground-Glass Nodules: A Prospective, Randomized Controlled Trial

The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.

Start Date15 Apr 2025

Sponsor / Collaborator

Shanghai Chest Hospital

ChiCTR2400088311

/ RecruitingNot ApplicableIIT

Clinical application of electromagnetic navigation bronchoscopy and microwave ablation in the treatment of pulmonary ground glass nodules

Start Date15 Aug 2024

Sponsor / Collaborator-

100 Clinical Results associated with Ground glass lung nodule

100 Translational Medicine associated with Ground glass lung nodule

0 Patents (Medical) associated with Ground glass lung nodule

1,024

Literatures (Medical) associated with Ground glass lung nodule

01 Jun 2025·Biochemistry and Biophysics Reports

Novel causes and assessments of intrapulmonary metastasis

Article

Author: Liu, Dazhi ; Cheng, Ming ; Xu, Wei ; Shao, Shujun

BackgroundThis study utilized next-generation sequencing (NGS) to analyze genetic information and gene mutation-related loci in ground glass nodules (GGN) with multiple (≥2) lesions. Pathological findings were then correlated to distinguish between multiple primary lung cancers (MPLC) and pulmonary metastasis (PM).MethodsA cohort of 20 individuals who underwent surgical resection for ground glass nodules (GGN) was included. Final diagnosis and restaging were determined based on the analysis of clinical characteristics and NGS single-target genetic detection.ResultsHistopathological, immunohistochemical staining, and NGS analyses identified 48 tissue samples from 20 cases of multiple malignant nodules. A total of 66 gene mutations were identified, with four cases classified as PM. Notably, four patients with intrapulmonary metastases exhibited concurrent mutations in the epidermal growth factor receptor (EGFR) (50 %) and Kirsten ratsarcoma viral oncogene homolog (KRAS). Comparatively, the prevalence of EGFR mutations in PM patients was significantly higher than that in primary lesions.ConclusionGenomic analysis of multiple lung adenocarcinomas enables the determination of the clonal status of tumor cells across various lesions. When gene mutation sites in multiple lesions are identical and mutation abundance is significantly elevated, early intrapulmonary metastasis may be diagnosed.

01 Jun 2025·Clinical Radiology

Incidence and influencing factors of vasovagal reaction in computed tomography (CT)-guided localisation of pulmonary ground-glass nodules prior to video-assisted thoracoscopic surgery

Article

Author: Huang, Z G ; Hu, Y W ; Zhang, T Y ; Sun, H L ; Xu, Y Y ; Wang, Y L ; Li, H Y ; Gao, B X ; Li, C D ; Feng, H X

AIMTo investigate the incidence, clinical features, and influencing factors of vasovagal reaction (VVR) associated with computed tomography (CT)-guided localisation of pulmonary ground-glass nodules (GGNs) prior to video-assisted thoracoscopic surgery (VATS).MATERIALS AND METHODSA total of 1303 consecutive patients who underwent CT-guided localisation of GGNs were selected as research subjects. VVR related to CT-guided localisation was defined as the onset of otherwise unexplained transient hypotension and/or relative bradycardia during or after localisation, manifesting as symptoms such as pallor, sweating, nausea, and potentially syncope. Risk factors for VVR were identified through both univariate and multivariate analyses.RESULTSVVR was observed in 4.5% (58/1,303) of the patients. All VVRs occurred postlocalisation, with 91.4% (53/58) happening between the time patients rose from the CT table and their departure from the CT room. Prodromal symptoms were evident in all VVR cases, with two cases progressing to syncope, each with a brief loss of consciousness lasting less than one minute. Univariate analysis identified significant risk factors for VVR, including patient age, stress level, history of syncope, and the marking of multiple GGNs, as well as marking time. Multivariate logistic regression analysis revealed that patient stress (odds ratio [OR], 20.17; P < 0.001) and a history of syncope (OR, 8.06; P = 0.002) were independent risk factors for VVR.CONCLUSIONVVR affects approximately 4.5% of patients undergoing CT-guided localisation of GGNs, often manifesting immediately after rising from the CT table. Patient stress and a history of syncope are significantly associated with an increased likelihood of VVR.

21 Apr 2025·Current Medical Imaging Formerly Current Medical Imaging Reviews

Radiomics of Vascular Structures in Pulmonary Ground-Glass Nodules: A Predictor of Invasiveness : Radiomics of Vascular Structures in GGNs for Tumor Invasiveness Prediction

Article

Author: Qi, Dong ; Wang, Wuling ; Yang, Hongkai ; Qi, Xuan ; Chen, Qiong ; He, Yongsheng ; Tang, Zhen

Objective:The global incidence of lung cancer highlights the need for improved assessment of nodule characteristics to enhance early detection of lung adenocarcinoma presenting as ground-glass nodules (GGNs). This study investigated the applicability of radiomics features of vascular structures within GGNs for predicting invasiveness of GGNs.Methods:In total, 165 pathologically confirmed pulmonary GGNs were retrospectively analyzed. The nodules were classified into preinvasive and invasive groups and randomly categorized into training and validation sets in a 7:3 ratio. Four models were constructed and evaluated: radiomics-GGN, radiomics-vascular, clinical-radiomics-GGN, and clinical-radiomics-vascular. The predictive performance of these models was assessed using receiver operating characteristic curves, decision curve analysis, calibration curves, and DeLong’s test.Results:Significant differences were observed between the preinvasive and invasive groups in terms of age, nodule length, average diameter, morphology, and lobulation sign (P = 0.006, 0.038, 0.046, 0.049, and 0.002, respectively). In the radiomics-GGN model, the support vector machine (SVM) approach outperformed logistic regression (LR), achieving an area under the curve (AUC) of 0.958 in the training set and 0.763 in the validation set. Similarly, in the radiomics-vascular model, the SVM approach outperformed LR. Furthermore, the clinical-radiomics-vascular model demonstrated superior predictive performance compared with the clinical-radiomics-GGN model, with an AUC of 0.918 in the training set and 0.864 in the validation set. DeLong’s test indicated significant differences in predicting the invasiveness of pulmonary nodules between the clinical-radiomics-vascular model and the clinical-radiomics-GGN model, both in the training and validation sets (P < 0.01).Conclusion:The radiomics models based on internal vascular structures of GGNs outperformed those based on GGNs alone, suggesting that incorporating vascular radiomics analysis can improve the noninvasive assessment of GGN invasiveness, thereby aiding in clinical decision-making and guiding biopsy selection and treatment planning.

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