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Last update 01 Nov 2024

Leprosy, Lepromatous

Last update 01 Nov 2024

Basic Info

Synonyms

Cutaneous Leprosies, Cutaneous Leprosy, Full lepromatous leprosy

+ [63]

Introduction

A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.

Drugs associated with Leprosy, Lepromatous

Thalidomide

Target

TNF

Mechanism

TNF inhibitors

Active Org.

Changzhou Pharmaceutical Factory Co., Ltd. [+8]

Originator Org.

Celgene Corp.

Active Indication

POEMS Syndrome [+6]

Inactive Indication

Advanced Hepatocellular Carcinoma [+30]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date16 Jul 1998

Clinical Trials associated with Leprosy, Lepromatous

CTRI/2024/07/070083 / Not yet recruitingPhase 4IIT

The Efficacy and Safety of Thalidomide versus Methotrexate in Erythema Nodosum Leprosum (ENL): A Randomized Controlled Trial - nil

Start Date20 Jul 2024

Sponsor / Collaborator-

CTRI/2024/05/067980 / RecruitingPhase 2IIT

The Effect of Yoga nidra on the levels of Stress, Anxiety and Depression in Hansens disease (RFT) – A Randomized controlled trial - NIL

Start Date04 Jun 2024

Sponsor / Collaborator-

CTRI/2024/03/064435 / Not yet recruitingPhase 3

A comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regime containing Rifampicin, Moxifloxacin and Clarithromycin (RMC) on Multibacillary patients from India. - NIL

Start Date05 Apr 2024

Sponsor / Collaborator-

100 Clinical Results associated with Leprosy, Lepromatous

100 Translational Medicine associated with Leprosy, Lepromatous

0 Patents (Medical) associated with Leprosy, Lepromatous

3,096

Literatures (Medical) associated with Leprosy, Lepromatous

01 Dec 2024·International Journal of Surgical Pathology

Concomitant Tuberculous and Lepromatous Lymphadenitis: Clues and Pitfalls of Leprosy Concealed by Tuberculosis in Lymph Nodes

Article

Author: AbdullGaffar, Badr ; Farhan, Rabiah ; Al-Dabal, Laila

Comorbidities between tuberculosis and leprosy are expected in endemic regions. Pulmonary tuberculosis and cutaneous leprosy are the most prevalent coinfections. One of the common manifestations of tuberculosis is generalized lymphadenopathy. In contrast, leprosy is clinically less suspected to manifest as a generalized lymphadenopathy, and it is pathologically unusual to diagnose leprosy primarily in lymph nodes. Concomitant tuberculous and lepromatous lymphadenitis are unprecedented and clinically unexpected, particularly in nonendemic countries. This imposes diagnostic challenges. We report concurrent tuberculosis and leprosy that were diagnosed in a lymph node in 45-year-old man with generalized lymphadenopathy. The effaced lymph node was predominantly replaced by caseating epithelioid granulomas alternating with foamy histiocytes. Ziehl-Neelsen stain showed positive acid-fast bacilli in the necrotizing granulomas only. The initial differential diagnosis of the nodal foamy macrophages included fungal infections, leishmaniasis, and Whipple disease, for which the special stains were negative. The vacuolated macrophages were disregarded as nonspecific lipogranuloma. A modified acid-fast stain was not considered. The histopathologic clues to nodal lepromatous leprosy included the presence of intracytoplasmic globi, intermixed microabscesses, and lymphoplasmacytic infiltrate and involved pericapsular nerves. Wade-Fite stain was subsequently performed. It revealed numerous lepra bacilli within the foamy histiocytes. The final diagnosis was concurrent disseminated tuberculosis and leprosy. Nodal lepromatous leprosy could be missed when compounded by concurrent nodal tuberculosis, particularly in developed countries. The clinicians and pathologists should have a high index of suspicion, particularly in patients from or with history of travel from endemic regions. Certain histopathologic features are helpful clues to avoid pitfalls.

01 Nov 2024·International Journal of Dermatology

Facial ulceration in a patient with lepromatous leprosy

Letter

Author: Sivakumar, Aravind ; Thappa, Devinder M. ; Srinivas, Bheemanathi H. ; Somasundaram, Arun ; Arulnathan, Arun P.

01 Nov 2024·eBioMedicine

Exhausted CD8 T cells and anti-inflammatory macrophages characterize lepromatous leprosy lesions

Article

Author: Via, Laura E. ; Mayer-Barber, Katrin D ; Barber, Daniel L. ; Mayer-Barber, Katrin D. ; Via, Laura E ; Barber, Daniel L

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Leprosy, Lepromatous

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