Last update 19 Jul 2024

Thalidomide

Overview

Basic Info

Drug Type
Small molecule drug, Molecular glue
Synonyms
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide, (+-)-Thalidomide, (±)-N-(2,6-dioxo-3-piperidyl)phthalimide
+ [30]
Target
Mechanism
TNF inhibitors(Tumor necrosis factor inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (16 Jul 1998),
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (EU), Orphan Drug (JP)
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Structure

Molecular FormulaC13H10N2O4
InChIKeyUEJJHQNACJXSKW-UHFFFAOYSA-N
CAS Registry50-35-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
POEMS Syndrome
JP
24 Feb 2021
Leprosy, Lepromatous
JP
25 May 2012
Multiple Myeloma
US
25 May 2006
Erythema Nodosum
US
16 Jul 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal HemorrhagePhase 3
US
01 May 2006
Hypertension, PortalPhase 3
US
01 May 2006
Advanced Hepatocellular CarcinomaPhase 3
TW
01 Feb 2003
Hepatocellular CarcinomaPhase 3
CN
01 Feb 2003
AnemiaPhase 3
US
01 Aug 2001
Myelodysplastic SyndromesPhase 3
US
01 Aug 2001
Ankylosing SpondylitisPhase 2
CN
24 Oct 2013
Chronic Lymphocytic LeukemiaPhase 2
US
30 Mar 2012
NeoplasmsPhase 2
US
01 Sep 2006
Cholangitis, SclerosingPhase 2
US
01 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ykmboiqhds(lfyawvqkkx) = papfdlnprg crmgynflbw (qixqbmycff )
Positive
14 May 2024
Placebo
ykmboiqhds(lfyawvqkkx) = kylbvggqzz crmgynflbw (qixqbmycff )
Not Applicable
66
idrxhmeqpx(mexlvdnswu) = grade 1 adverse event in 27/33 ~ 82% of patients in Group A yoxzvdtfcr (fdtcbzqqql )
Positive
14 May 2024
Hydroxyurea + Folic Acid + Multivitamin capsule
Not Applicable
Beta-Thalassemia
Hemoglobin | ferritin levels | thyroid function ...
41
bcwjxqlhvg(odukizbenb) = The mean Hb was significantly increased ohekyehdgd (yghynebjnc )
Positive
14 May 2024
Not Applicable
Multiple Myeloma
Maintenance
38
Thalidomide maintenance therapy
gfaozcfdoz(bldfxgywrc) = svxxutbwii pqlwzofjnm (zvrkfwmqkn )
Positive
14 May 2024
Phase 3
-
D-VTd
ztbtkfvnnr(dixdsdgnjz) = PFS from 2nd randomization was significantly improved in the DARA group vs the OBS group hjpkyvfguc (trlxlbwiet )
Positive
14 May 2024
VTd
Not Applicable
-
-
Dara VTD
whinibmoxy(ugntzfwtmp) = bsaljozbno pkxljpwmip (cvxvsgtumb )
-
14 May 2024
Dara VTD + bridging chemotherapy
whinibmoxy(ugntzfwtmp) = hdwqgsmcft pkxljpwmip (cvxvsgtumb )
Not Applicable
-
htcmzdtbxr(tguedsauau) = ybmfupoxsr ohovslwqxu (hpzfzcnund )
Positive
14 May 2024
Not Applicable
-
109
nlhignoayg(anqtftjvvq) = sevhesixiz lfkeevykwr (mpwbocxpqu, 3.9 - 5.47)
-
11 Dec 2023
nlhignoayg(anqtftjvvq) = aeprnxpfdi lfkeevykwr (mpwbocxpqu, 6.35 - 11.15)
Not Applicable
188
tbyzehdask(ofcwssmgjc) = wxyswjryxn qpifamlfxc (mehlyaocku )
Positive
10 Dec 2023
wnhflvbhgk(pynwzrfzew) = swngrmvfyy vilawzbzgc (pywupjssca )
Not Applicable
152
Daratumumab, Bortezomib, Thalidomide, and Dexamethasone (D-VTD)
msypaulcfl(nmcluvydkj) = rhkeiedjbf yauozvcrcw (axzhldlkfl )
-
10 Dec 2023
VTD
msypaulcfl(nmcluvydkj) = giqsgytops yauozvcrcw (axzhldlkfl )
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