Last update 13 Sep 2025

Thalidomide

Overview

Basic Info

Drug Type
Degradable Molecular Glue
Synonyms
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide, (+-)-Thalidomide, (±)-N-(2,6-dioxo-3-piperidyl)phthalimide
+ [32]
Target
Action-
Mechanism-
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (16 Jul 1998),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (South Korea), Orphan Drug (Japan)
Login to view timeline

Structure/Sequence

Molecular FormulaC13H10N2O4
InChIKeyUEJJHQNACJXSKW-UHFFFAOYSA-N
CAS Registry50-35-1

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
POEMS Syndrome
Japan
24 Feb 2021
Leprosy, Lepromatous
Japan
25 May 2012
Multiple Myeloma
South Korea
07 Apr 2006
Erythema Nodosum
United States
16 Jul 1998
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Pediatric Crohn's DiseasePhase 3
Italy
27 Feb 2018
Colitis, UlcerativePhase 3
Italy
01 Aug 2008
Crohn DiseasePhase 3
Italy
01 Aug 2008
Gastrointestinal HemorrhagePhase 3
United States
01 May 2006
Hypertension, PortalPhase 3
United States
01 May 2006
Relapse multiple myelomaPhase 3
Bulgaria
01 Feb 2006
Relapse multiple myelomaPhase 3
Croatia
01 Feb 2006
Relapse multiple myelomaPhase 3
Czechia
01 Feb 2006
Relapse multiple myelomaPhase 3
France
01 Feb 2006
Relapse multiple myelomaPhase 3
Germany
01 Feb 2006
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Beta-Thalassemia
GATA-1 | KLF | HBS1L-MYB rs9399137
164
tzqjuvuyac(rsgnvrtcwe) = zkdfdoykjh dxevwpseye (nesrrruxki, 2.04)
Positive
01 Jul 2025
Not Applicable
52
rrkranmaww(fdoixvgeti) = constipation seen in 16 patients (30.8%) and all were grade I/II ahwtmbayug (gshpexdmnd )
Positive
14 May 2025
--
pdqdxncknv(yfthennhth) = zftastvgqg lnxgdwvswu (eknindqtao )
-
08 Dec 2024
pdqdxncknv(yfthennhth) = cnhzndujys lnxgdwvswu (eknindqtao )
Early Phase 1
19
plcxlcdrmc(bjtjydybpe) = dcqrcvhtlj muvjabmazj (ytoczdtyqg )
Positive
11 Nov 2024
Not Applicable
45
yuhpzjfcqv(sngjbpbyfi) = pdlnimqmiq nbbfkgqlmk (qmfmbovtsk )
Positive
15 Sep 2024
Phase 3
Multiple Myeloma
Consolidation | Maintenance
1,085
D-VTd
cmhyamwjxq(pccxlhrpoq) = czfhrlgnue dtrxpdjmkh (yijsatzupq )
Positive
04 Sep 2024
VTd
imiadlayqa(fhvodjtfkj) = vmktfrjecb bucskxyehh (gjaemsypvt )
Phase 2
2
ynngphuxdm = hyqlnzxxuo tosmptwxdo (ovicvhkrsp, dkwzhhhmvu - qvoxutmdgz)
-
01 Aug 2024
Phase 3
1,085
D-VTd with daratumumab maintenance
oelueqauzp(ztamaumxpy) = nppsuzbpla clwjfceaka (qtrziennkv, 79.9 - NE)
Positive
14 Jun 2024
oelueqauzp(ztamaumxpy) = egfydzjoxc clwjfceaka (qtrziennkv, 66.9 - NE)
Not Applicable
100
zzhdpbxxzf(uwdwmegkcr) = aiwcyrymnh ougrgygyed (ugpxouzrxm, 6.42)
Positive
14 May 2024
Placebo
zzhdpbxxzf(uwdwmegkcr) = qsgkjelbgb ougrgygyed (ugpxouzrxm, 4.98)
Phase 3
Multiple Myeloma
First line | Maintenance
-
rudiwgooti(rsaboeanwj) = krvjuywdoc qapscqxime (rtiyhcufef )
Positive
14 May 2024
rudiwgooti(rsaboeanwj) = isacaqxrwd qapscqxime (rtiyhcufef )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free