Moderate to severe acne

Healthy Chinese subjects were used as test subjects. A self-crossover design was used to determine the time course of doxycycline concentration in plasma after administration of doxycycline hydrochloride tablets produced by Dequan Pharmaceutical (Jiangsu) Co., Ltd., and to estimate the corresponding pharmacokinetic parameters. Doxycycline hydrochloride tablets produced by Pfizer Japan Inc. under a license [trade name: Vibramycin, specification: 100 mg (calculated as C22H24NO8)] were used as reference to evaluate the bioequivalence between the preparations and to observe the safety of doxycycline hydrochloride tablets in healthy Chinese subjects.