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Last update 08 May 2025

Paracoccidioidomycosis

Last update 08 May 2025

Basic Info

Synonyms

Almeida, BLASTOMYCOSIS, SOUTH AMERICAN, Blastomycosis, South American

+ [57]

Introduction

A mycosis affecting the skin, mucous membranes, lymph nodes, and internal organs. It is caused most often by Paracoccidioides brasiliensis. It is also called paracoccidioidal granuloma.

Drugs associated with Paracoccidioidomycosis

Ketoconazole

Target

C14DM

Mechanism

C14DM antagonists [+1]

Active Org.

Teikoku Seiyaku Co. Ltd. [+5]

Originator Org.

Janssen Pharmaceutica NV

Active Indication

Endogenous Cushing Syndrome [+13]

Inactive Indication

Advanced cancer [+3]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date12 Jun 1981

Clinical Trials associated with Paracoccidioidomycosis

NCT06523998

/ CompletedNot ApplicableIIT

Retrospective Descriptive Observational Study of the Epidemiological, Clinical and Therapeutic Profile of Patients With Rare Infections of Dermatological Interest at Three Major Reference Hospitals in Costa Rica From 2019-2023

In Costa Rica there are some descriptive studies of some of these rare infectious diseases (sporotrichosis, chromomycosis and mycetomas); however, there are no recent published reports. Most of the publications on the subject date back to the previous century; from 2000 to the present year there are only publications of small series of cases, so the current behavior of these skin infections is unknown. The primary objective is to analyze the epidemiological, clinical, and therapeutic profile and determine the risk factors in patients with a diagnosis of rare infections of dermatological interest treated at Hospital México, Hospital Rafael Calderón Guardia, and Hospital San Juan de Dios during the period 2019-2023.

Start Date11 Dec 2023

Sponsor / Collaborator-

DRKS00022878

/ CompletedNot ApplicableIIT

A multicenter study to increasedrug safety concerning the usage of systemic antifungal agents in haematology and oncology - MAAMy

Start Date01 Apr 2021

Sponsor / Collaborator-

100 Clinical Results associated with Paracoccidioidomycosis

100 Translational Medicine associated with Paracoccidioidomycosis

0 Patents (Medical) associated with Paracoccidioidomycosis

2,020

Literatures (Medical) associated with Paracoccidioidomycosis

01 Apr 2025·Molecular Aspects of Medicine

When to suspect and how properly early detect and treat patients with endemic mycoses

Review

Author: Santos, Daniel Wagner de C L ; Peçanha-Pietrobom, Paula M ; Colombo, Arnaldo L ; Caceres, Diego H

Endemic mycoses are caused by dimorphic fungi and eventually molds, as the case of implantation mycoses. In general, these diseases are acquired through trauma or inhalation of fungal elements in the environment, and less frequently by zoonotic acquisition or transmitted during organ transplantation. The target population for endemic mycoses is usually represented by normal hosts with low-income and intensive outdoor activities. Awareness of these diseases remains limited, even in regions with high prevalence, resulting in delayed diagnosis, and affecting the quality of life and outcomes of patients who suffer from these entities. In this review, we summarized relevant information about epidemiological, clinical, diagnostic, and treatment aspects of the most common endemic mycoses, including blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycoses, talaromycosis, and implantation mycoses. The main goal of this review is to provide key concepts in terms of when to suspect, how early diagnose, and properly treat patients with these mycoses.

27 Mar 2025·Open Forum Infectious Diseases

Paracoccidioidomycosis as a Manifestation of Immune Reconstitution Inflammatory Syndrome in an HIV Patient: An Uncommon Presentation

Article

Author: Lima, Luiz A A ; Carneiro, Ana H P C ; Djahjah, Maria Célia ; Mendes, Isabel C M ; Lóta, Francine C ; Paschoal, Marilene M ; Silva, Amanda P O ; Souza, Sergio A L

AbstractA 50-year-old HIV-positive woman, nonadherent to antiretroviral therapy, developed asthenia, weight loss, and lymphadenopathy after restarting treatment. Imaging revealed adenopathies and a breast nodule, with biopsies confirming Paracoccidioides brasiliensis. Despite initial therapy failure (trimethoprim-sulfamethoxazole), liposomal amphotericin, corticosteroids, and a regimen change led to partial improvement until a psoas abscess required drainage, ultimately stabilizing her condition.

14 Feb 2025·Medicine

First case report of long-term latent infection paracoccidioidomycosis in China

Article

Author: Wu, Shaoling ; Dong, Haiping ; Tang, Guidan ; Liang, Xiaocheng ; Wang, Weiyong ; Liang, Feng ; Hu, Jinxing ; Liao, Weixiang ; Li, Hua ; Pan, Yanshan ; Cao, Zhizhong ; Li, Donghai ; Feng, Jingyuan ; Zhou, Wei

Rationale:Although paracoccidioidomycosis is one of the most prevalent endemic mycoses in Latin American countries, where at least 10 million people are infected, the prevalence of paracoccidioidomycosis in China remains unknown because no related case has been reported, and its diagnosis is extremely challenging for local clinicians because of the complexity of disease progression and lack of specific evidence.Patient concerns:Here, we report the first case of PCM in a male patient with a long-term latent infection in China.Diagnosis:The results of special staining, immunohistochemistry, lymph node biopsy pathology, and metagenomic second-generation sequencing indicated that the patient was infected with Paracoccidioides brasiliensis.Interventions:In this case, the patient was administered voriconazole 200 mg twice daily.Outcomes:After continuous treatment for 6 months, the patient’s symptoms improved significantly, and the medication was discontinued. The outpatient follow-up revealed no discomfort.Lessons:This case is of great value for the early diagnosis, treatment, and prevention of the spread of this emerging infectious disease in China.

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Paracoccidioidomycosis

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