Last update 01 Nov 2024

Malignant Gastric Gastrointestinal Stromal Tumor

Last update 01 Nov 2024

Basic Info

Synonyms

Gastric Malignant Gastrointestinal Stromal Tumor, Malignant Gastric Gastrointestinal Stromal Tumor

Introduction

A gastrointestinal stromal tumor arising from the stomach. It is characterized by large size (diameter greater than 10 cm) or more than 5 mitotic figures per 50 high power fields.

Drugs associated with Malignant Gastric Gastrointestinal Stromal Tumor

Sunitinib Malate

Target

PDGFR x RTK x VEGFR

Mechanism

PDGFR antagonists [+2]

Active Org.

Pfizer Japan, Inc. [+4]

Originator Org.

Pfizer Inc.

Active Indication

Malignant Gastric Gastrointestinal Stromal Tumor [+12]

Inactive Indication

Adrenocortical Carcinoma [+76]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date26 Jan 2006

Imatinib mesylate

Target

ABL x Bcr-Abl x PDGFR x c-Kit

Mechanism

ABL inhibitors [+3]

Active Org.

National Cancer Institute [+11]

Originator Org.

Novartis Pharma AG

Active Indication

Metastatic Gastrointestinal Stromal Tumor [+28]

Inactive Indication

Abdominal Neoplasms [+169]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date10 May 2001

Ziftomenib

Target

MLL1 x menin

Mechanism

MLL1 inhibitors [+2]

Active Org.

Kura Oncology, Inc.

Originator Org.

Kura Oncology, Inc.

Active Indication

Acute Myeloid Leukemia [+9]

Inactive Indication

Acute Lymphoblastic Leukemia

Drug Highest PhasePhase 1/2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Malignant Gastric Gastrointestinal Stromal Tumor

NCT06655246 / Not yet recruitingPhase 1

A Phase 1a/1b Study of the Safety, Pharmacokinetics, and Antitumor Activity of the Oral Menin Inhibitor Ziftomenib in Combination with Imatinib in Patients with Advanced Gastrointestinal Stromal Tumors (GIST) After Imatinib Failure

In this clinical trial, the safety, tolerability, and preliminary antitumor activity of ziftomenib in combination with imatinib will be evaluated in adults with gastrointestinal stromal tumors (GIST) who have been treated previously with imatinib.

Start Date01 Jan 2025

Sponsor / Collaborator

Kura Oncology, Inc.

CTR20230186 / CompletedNot Applicable

甲磺酸伊马替尼片随机、开放、两制剂、两周期、两序列交叉、单次给药（0.1 g）、餐后状态下健康人体生物等效性试验

[Translation] A randomized, open-label, two-formulation, two-period, two-sequence crossover, single-dose (0.1 g) bioequivalence study of imatinib mesylate tablets in healthy volunteers in the postprandial state

主要目的：以浙江麒正药业有限公司提供的甲磺酸伊马替尼片为受试制剂，按生物等效性试验的有关规定，与持证商 Novartis Pharma Schweiz AG的甲磺酸伊马替尼片（商品名：格列卫®，参比制剂）对比在健康人体内的吸收速度及吸收程度，考察两制剂的人体生物等效性。次要目的：观察受试制剂甲磺酸伊马替尼片和参比制剂甲磺酸伊马替尼片（格列卫®）在健康受试者中的安全性。

[Translation]

Main purpose: Using imatinib mesylate tablets provided by Zhejiang Qizheng Pharmaceutical Co., Ltd. as the test preparation, according to the relevant provisions of the bioequivalence test, the absorption rate and degree of imatinib mesylate tablets (trade name: Gleevec®, reference preparation) of the licensed manufacturer Novartis Pharma Schweiz AG were compared in healthy humans, and the human bioequivalence of the two preparations was investigated. Secondary purpose: To observe the safety of the test preparation imatinib mesylate tablets and the reference preparation imatinib mesylate tablets (Gleevec®) in healthy subjects.

Start Date14 Feb 2023

Sponsor / Collaborator

Zhejiang Qizheng Pharmaceutical Co., Ltd

ChiCTR2200062796 / SuspendedNot ApplicableIIT

A single-center study comparing the safety and efficacy of endoscopic versus laparoscopic resection of gastrointestinal stromal tumors >= 3cm in diameter

Start Date19 Aug 2022

Sponsor / Collaborator

Taizhou Hospital of Zhejiang Province

100 Clinical Results associated with Malignant Gastric Gastrointestinal Stromal Tumor

100 Translational Medicine associated with Malignant Gastric Gastrointestinal Stromal Tumor

0 Patents (Medical) associated with Malignant Gastric Gastrointestinal Stromal Tumor

311

Literatures (Medical) associated with Malignant Gastric Gastrointestinal Stromal Tumor

01 Sep 2024·International Journal of Surgery Case Reports

Minimally invasive resection of gastric GIST tumor by trans-gastric approach: A case report of a novel technique

Article

Author: Omouri, Adel ; Hamed, Sami ; Kansoun, Alaa

INTRODUCTION AND IMPORTANCEGIST (Gastro Intestinal Stromal Tumor) treatment is surgical however surgical resection, especially for gGIST (gastric GIST), may be challenging due to location of tumor and the possible sequelae post resection.CASE PRESENTATIONWe present a case of 66-year-old female presented for the management of gGIST. We opted for transgastric resection assisted by robot. The resection was with free surgical margins for a 4 cm GIST tumor low in grade.CLINICAL DISCUSSIONClassical wedge resection of gastric tumors poses post-operative complications especially if the tumor is located near the cardia or pylorus. Various minimally invasive techniques were described aiming to avoid post-operative complications as in stenosis and gastric reflux.CONCLUSIONMinimally invasive transgastric resection of gGIST tumor seems to be worth of attention for it can prevent stenosis, hemorrhage and can preserve gastric tissue. Further studies need to be involved to endorse this technique.

01 Jul 2024·Hepatobiliary & Pancreatic Diseases International

Left hepatic marginal hemangioma with features resembling gastric stromal tumor

Letter

Author: Gao, Tian-Zhe ; Si, Yong-Qiang ; Wu, Xing-Nan ; Liu, Xiao-Sun ; Xu, Jia-Ren

12 Apr 2024·Alternative therapies in health and medicine

Diagnostic Value of Transabdominal Ultrasonography in Gastrointestinal Malignant Tumors.

Article

Author: Zheng, Jing ; Gao, Yan-Bing ; Tang, Li-Wei ; Dong, Jing-Yun

ObjectiveTo explore the application value of transabdominal ultrasonography in the diagnosis of gastrointestinal malignant tumors.MethodsThis study retrospectively analyzed the transabdominal ultrasound imaging data of 284 patients with gastrointestinal tumors admitted to our hospital from April 2019 to March 2022 and assessed the accuracy of transabdominal ultrasound in diagnosing different types of gastrointestinal tumor diseases. The diagnostic accuracy of transabdominal ultrasonography for TNM staging of gastrointestinal malignancies was calculated.ResultsThe sensitivity and specificity of transabdominal ultrasonography in the diagnosis of gastric cancer were (82.40% and 83.72%, respectively), colon cancer (77.78% and 88.35%, respectively), gastric stromal tumor (95.45% and 93.65%, respectively), gastric lymphoma (72.22% and 94.66%, respectively), colorectal lymphoma (80.00% and 95.42%, respectively), gastric mucosal hypertrophy (85.71% and 96.69%, respectively), and pyloric hypertrophy (92.59% and 97.79%, respectively). Among the 284 patients included, 152 patients had malignant tumors, including 34 patients with stage I, 30 patients with stage II, 51 patients with stage III, and 37 patients with stage IV. The accuracy of transabdominal ultrasonography for TNM staging of gastrointestinal malignancies was 85.53% (130/152).ConclusionTransabdominal ultrasonography shows promise as a diagnostic tool for gastrointestinal malignant tumors; however, it is recommended to be used in conjunction with other detection methods such as fibrous gastrointestinal tract examination to minimize the risk of missed diagnoses and misdiagnoses. The study highlights the potential of transabdominal ultrasonography as a non-invasive and accessible diagnostic method for gastrointestinal malignancies. Further research and advancements in imaging technologies are crucial for enhancing diagnostic capabilities and improving patient outcomes in the future.

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