Last update 21 Mar 2024

Malignant Gastric Gastrointestinal Stromal Tumor

Last update 21 Mar 2024

Basic Info

Synonyms

Gastric Malignant Gastrointestinal Stromal Tumor, Malignant Gastric Gastrointestinal Stromal Tumor

Introduction

A gastrointestinal stromal tumor arising from the stomach. It is characterized by large size (diameter greater than 10 cm) or more than 5 mitotic figures per 50 high power fields.

Clinical Trials associated with Malignant Gastric Gastrointestinal Stromal Tumor

CTR20230186 / CompletedNot Applicable

甲磺酸伊马替尼片随机、开放、两制剂、两周期、两序列交叉、单次给药（0.1 g）、餐后状态下健康人体生物等效性试验

[Translation] Imatinib Mesylate Tablets Randomized, Open, Two Preparations, Two Periods, Two Sequences Crossover, Single Administration (0.1 g), Bioequivalence Study on Healthy Humans in Postprandial State

主要目的：以浙江麒正药业有限公司提供的甲磺酸伊马替尼片为受试制剂，按生物等效性试验的有关规定，与持证商 Novartis Pharma Schweiz AG的甲磺酸伊马替尼片（商品名：格列卫®，参比制剂）对比在健康人体内的吸收速度及吸收程度，考察两制剂的人体生物等效性。次要目的：观察受试制剂甲磺酸伊马替尼片和参比制剂甲磺酸伊马替尼片（格列卫®）在健康受试者中的安全性。

[Translation]

Main purpose: Using imatinib mesylate tablets provided by Zhejiang Qizheng Pharmaceutical Co., Ltd. Compare the absorption rate and degree of absorption of Tini tablets (trade name: Gleevec®, reference preparation) in healthy humans, and investigate the human bioequivalence of the two preparations. Secondary purpose: To observe the safety of the test preparation imatinib mesylate tablets and the reference preparation imatinib mesylate tablets (Gleevec®) in healthy subjects.

Start Date14 Feb 2023

Sponsor / Collaborator

Zhejiang Qizheng Pharmaceutical Co., Ltd

CTR20222403 / Active, not recruitingNot Applicable

甲磺酸伊马替尼片在健康受试者中随机、开放、两制剂、单次给药、两周期、两序列餐后状态下的生物等效性试验

[Translation] Bioequivalence trial of imatinib mesylate tablets in healthy subjects in a randomized, open-label, two-dose, single-dose, two-cycle, two-sequence postprandial state

主要目的：考察广州科锐特生物科技有限公司研制的受试制剂甲磺酸伊马替尼片（100mg）与Novartis Pharma Stein AG生产的参比制剂（格列卫®100mg）的相关药代动力学参数及相对生物利用度，评价两制剂的生物等效性，为广州科锐特生物科技有限公司研制的甲磺酸伊马替尼片的临床应用提供依据。次要目的：观察两制剂在餐后条件下健康受试者中的安全性。

[Translation]

Main purpose: To investigate the related pharmacokinetics of the test preparation imatinib mesylate tablets (100mg) developed by Guangzhou Crete Biotechnology Co., Ltd. and the reference preparation (Gleevec® 100mg) produced by Novartis Pharma Stein AG The biological parameters and relative bioavailability of the two preparations were evaluated, and the bioequivalence of the two preparations was evaluated, which provided the basis for the clinical application of imatinib mesylate tablets developed by Guangzhou Career Biotechnology Co., Ltd. Secondary objective: To observe the safety of both formulations in healthy subjects under postprandial conditions.

Start Date11 Aug 2022

Sponsor / Collaborator

Guangzhou Keruite Biotechnology Co., Ltd

NCT04825470 / Not yet recruitingNot ApplicableIIT

Liver Transplantation in Patients With Unresectable GastroIntestinal Stromal Tumors (GIST) Liver Metastases

Liver Transplantation for Unresectable GIST Liver Metastases

Start Date01 May 2022

Sponsor / Collaborator-

100 Clinical Results associated with Malignant Gastric Gastrointestinal Stromal Tumor

100 Translational Medicine associated with Malignant Gastric Gastrointestinal Stromal Tumor

0 Patents (Medical) associated with Malignant Gastric Gastrointestinal Stromal Tumor

267

Literatures (Medical) associated with Malignant Gastric Gastrointestinal Stromal Tumor

25 Dec 2023·Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[A case of diaphragmatic hemangioma misdiagnosed as gastrointestinal stromal tumor of stomach].

Article

Author: H H Guo ; B Y Song ; X R Wang ; J X Cui ; Z B Zhang ; B Y Wang ; Y Liu ; B B Tan ; Q Zhao

01 Dec 2023·Endoscopy

Correction: A loop-assisted inversion technique for easy removal of a gastric stromal tumor in the fundus.

Article

Author: Zhang Tao ; Long Chen ; Jie Liu ; Yi Ming Peng ; Feng Ying Lin ; Liang Sun ; Jian Chen

15 Jul 2023·Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

Clinical observation of laparoscopic seromuscular dissection in the treatment of gastric stromal tumors.

Article

Author: Baohang Fan ; Keli Zhong ; Zhao Chen

OBJECTIVE:

To investigate the safety and oncological prognosis of laparoscopic seromuscular dissection (LSD) in the treatment of gastric stromal tumors.

MATERIAL AND METHODS:

From June 2016 to July 2022, 67 patients with gastric stromal tumors underwent laparoscopic seromuscular dissection (LSD), and 58 patients underwent non-LSD surgery during the same period (52 patients underwent laparoscopic gastric wedge resection (LWR), two patients underwent proximal gastrectomy, three patients underwent total gastrectomy, one patient underwent distal gastrectomy and partial hepatectomy). Gastric stromal tumor patients were compared to compare the surgical results, tumor relapse rate, and survival rate of the two groups.

RESULTS:

The results of the two groups were compared. For gastric stromal tumors, especially gastric stromal tumors located at 'difficult sites', LSD can reduce the amount of bleeding and the number of cutting staplers used during the operation, reduce the incidence of postoperative complications, shorten the postoperative hospitalization time, reduce the hospitalization cost and improve the quality of life of patients without increasing the operation time.

CONCLUSION:

Laparoscopic seromuscular dissection for gastric stromal tumors is safe and technically feasible in the hands of experienced laparoscopic surgeons.

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Malignant Gastric Gastrointestinal Stromal Tumor

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