Last update 01 Nov 2024

Nonpuerperal Galactorrhea

Last update 01 Nov 2024

Basic Info

Synonyms

AMENORRHEA-GALACTORRHEA SYNDROME, Ahumada-Del Castillo syndrome, Ahumada-del Castillo

+ [66]

Introduction

Spontaneous flow of milk from the breast, unassociated with childbirth or nursing. [https://orcid.org/0009-0006-4530-3154]

Drugs associated with Nonpuerperal Galactorrhea

Merotocin

Target

OXTR

Mechanism

OXTR agonists

Active Org.

Ferring BV

Originator Org.

Ferring BV

Active Indication

Lactation Disorders

Inactive Indication

Nonpuerperal Galactorrhea [+1]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Nonpuerperal Galactorrhea

NCT04614714 / Not yet recruitingPhase 2/3IIT

Nicotinamide Riboside and Milk Production in the NICU

Breastfeeding has well-established immunity and developmental benefits for newborns, yet mothers of preterm infants often struggle to provide sufficient breast milk. The investigators hypothesize that supplementing mothers of preterm infants with nicotinamide riboside (NR) during early postpartum will result in increased milk production. NR is a unique precursor to NAD+, which functions in whole-body metabolism, including that which supports the elevated energy demands of lactation. In lactating rats, NR supplementation improved milk quantity and quality, with metabolic benefits for the mother and lasting protective advantages for the offspring. No studies have been conducted to date that explore the short- or long-term use of NR for increasing milk supply in lactating women. This study will follow a small cohort of women and very preterm infants in the NICU throughout two intervention phases-- one in which each mother will randomly receive either NR or a placebo, then the opposite treatment-- to determine the effect of maternal NR supplementation on expressed milk volume and other markers of metabolism.

Start Date01 Dec 2024

Sponsor / Collaborator

University of California, Davis

IRCT20240522061869N1 / SuspendedPhase 3IIT

Comparison effects of lactation induction protocol in non-pregnant mothers waiting for the birth of a baby from surrogacy according to the treatment duration

Start Date21 Aug 2024

Sponsor / Collaborator

Tehran University of Medical Sciences

ChiCTR2400087655 / SuspendedNot ApplicableIIT

Mechanism of Non-puerperal Mastitis in Early Stage and the Value of Glucocorticoids Therapy

Start Date01 Aug 2024

Sponsor / Collaborator-

100 Clinical Results associated with Nonpuerperal Galactorrhea

100 Translational Medicine associated with Nonpuerperal Galactorrhea

0 Patents (Medical) associated with Nonpuerperal Galactorrhea

410

Literatures (Medical) associated with Nonpuerperal Galactorrhea

01 Nov 2024·Tropical Animal Health and Production

The investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes

Article

Author: Hasan, Mubeen Ul ; Ceyhan, Ayhan

BACKGROUNDLivestock farmers face financial losses every year because milk yield and components are severely affected by udder diseases. These udder infections attract the immune response from the host and lead to the influx of neutrophils into milk to fight infection and thus the number of somatic cell count (SCC) is increased. The SCC value of milk could be used as an important indicator in detecting clinical mastitis in dairy animals. Also, the milk yield and milk quality (e.g. fat) are negatively affected by the increased SCC. The SCC is used to estimate the somatic cell score (SCS)of the milk, which is used as an indirect measure to detect subclinical mastitis. Therefore, the purpose of this study was to investigate the presence of a significant SNP rs868996547, on the suppressor of cytokine signaling 2 gene (SOCS2) which is related to milk yield and milk quality in Awassi sheep.METHODSIn this study, milk production data was obtained from 210 healthy Awassi ewes with different parties and ages. The general linear model (GLM) process analysis of variance (ANOVA) was used to determine fixed effects on milk traits. The DNA extraction was done using a blood DNA extraction kit from Qiagen. To validate the presence of SNP a customized SNP detection developed by Thermofisher Scientific was used. The presence of the SNP in the SOCS2 gene was detected with genotypes (C/T, T/T, and C/C) and T being the mutated allele and it had a significant (p < 0.015) effect on the milk yield (p < 0,015;0.091), fat (p < 0,001;0,003), fat/protein ratio (p < 0.001;0,037) and log10SCC value (p < 0,006;0,015) of Awassi ewes. However, the protein, total solid, and lactose percentages in the wild type and the mutated ewes found having no significant difference (P > 0.05).CONCLUSIONOur result showed the increase in SCC or SCS of the milk significantly affected the milk yield and composition. Parity and age had significant effects on ewes' milk yield (p < 0.001). In conclusion, we investigated the presence of SOCS2 gene of Awassi ewes in the study flock and its effect on milk yield, fat, and somatic cell count, and the change in milk composition and milk yield because of SCC.

01 Oct 2024·animal

Sow and litter performance after cross-fostering one surplus piglet and co-mingling the litters at early lactation

Article

Author: Zanin, G.P. ; Zanin, G P ; Mellagi, A.P.G. ; Silveira, D.F. ; Tomm, D.M.S. ; Santos, L ; Bortolozzo, F.P. ; Tomm, D M S ; Santos, L. ; Ulguim, R.R. ; Mellagi, A P G ; Bortolozzo, F P ; Ulguim, R R ; Silveira, D F

The number of piglets born alive is frequently greater than the functional teats, and some farms are equalizing litters with surplus piglets, limiting piglet udder access. Removing the barrier among farrowing crates may allow piglets to socialize and seek other sows. Thus, we evaluated the effects litter size at cross-fostering and socialization on the sow and piglet performance during lactation. Two factors were included in a 2 × 2 factorial design: socialization and litter size relative to sow functional teat number at cross-fostering. Litters (n = 189) were then assigned to one of four groups: CONT+0 (litters not co-mingled with no additional piglet), CONT+1 (not co-mingled with one additional piglet), Co-M+0 (co-mingled with no additional piglet), Co-M+1 (co-mingled with one additional piglet). Piglets were cross-fostered from 12-16 h after birth, and 24 h later, Co-M groups were socialized by removing the barrier between two adjacent pens. During lactation, sows lost more caliper units in the + 1 group than in the + 0 group (P = 0.04). The number of functional teats did not differ among groups, but Co-M sows had a higher udder lesion score at weaning than CONT (6.55 vs 4.83; P < 0.01). Furthermore, +1 sows had fewer vacant teats throughout lactation (P < 0.01). Milk yield did not differ among the groups (P ≥ 0.13). Regarding the number of weaned piglets, no difference was observed for socialization (P = 0.84), but + 1 sows weaned 0.67 more piglets than + 0 (P < 0.01). Although CONT+0 had the heaviest piglets at weaning (P < 0.01), litter weight did not differ among the groups (P ≥ 0.08). Facial and joint lesions were frequently observed in Co-M (P < 0.01) than CONT. Piglet loss rate did not differ among treatments (overall rate = 12.6%; P ≥ 0.26). The removal rate, however, was more frequent in + 1 litters than in + 0 (P < 0.01). Death due to starvation was higher in CONT+1 than CONT+0 (P < 0.01) but did not differ between the Co-M groups (P = 0.99). Litters formed with one additional piglet relative to functional teat number weaned more piglets, albeit with lower individual weight. Litter socialization may alleviate the impact of high litter size but shows greater percentages of udder injuries and facial and joint lesions in weaned piglets.

09 Aug 2024·Animals : an open access journal from MDPI

Isolation of Aerobic Bacterial Species Associated with Palpable Udder Defects in Non-Dairy Ewes.

Article

Author: Kenyon, Paul R ; Velathanthiri, Niluka ; Zeleke, Mandefrot M ; Flay, Kate J ; Pain, Sarah J ; Aberdein, Danielle ; Ridler, Anne L

The objectives of these studies were to identify associations between udder half defects (hard or lump) and bacteria isolated from milk or mammary tissue swabs, to compare with samples from normal udder halves at different physiological time points and to compare bacterial species isolated via milk and swabs of mammary tissue from within the same udder halves. A total of 1054 samples were aseptically collected from each udder half of 199 non-dairy breed (Romney) ewes from three different studies (Study A, n = 77; Study B, n = 74; and Study C, n = 48). Conventional bacterial culture and MALDI-ToF mass spectrometry were used for bacterial identification. Of the 225 samples from which bacteria were isolated, Mannheimia haemolytica and Streptococcus uberis were the dominantly identified species from defective udder halves, whereas coagulase-negative staphylococcus (CNS) species, mostly Staphylococcus simulans and Staphylococcus chromogenes, were more frequently isolated from normal udder halves. The ongoing presence of bacterial species over time was variable, although less frequently identified species showed less stability over time. A very high agreement (91.5%) of bacterial species identified was observed between the mammary tissue swab and udder half milk samples during post-weaning. In summary, palpable udder half defects were associated with bacterial positivity, and the ongoing presence of the bacteria over time was dependent on the species involved. Hence, culling ewes with palpable udder half defects that had more stable bacterial species could contribute to reducing the recurrence of palpable defects or mastitis.

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Nonpuerperal Galactorrhea

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