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Last update 23 Jan 2025

Tuberculoma

Last update 23 Jan 2025

Basic Info

Synonyms

Tuberculoma, Tuberculoma (disorder), Tuberculoma, NOS

+ [6]

Introduction

A tumor-like mass resulting from the enlargement of a tuberculous lesion.

Drugs associated with Tuberculoma

Ethambutol Hydrochloride/Isoniazid

Target

rpoB

Mechanism

rpoB inhibitors

Active Org.-

Originator Org.-

Active Indication

Tuberculoma

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Tuberculoma

IRCT20221108056446N6

/ SuspendedNot ApplicableIIT

A comparative study of CSF leak rate in Duraplasty using the Edge-In method with the conventional method in patients with spinal cord injury

Start Date20 Apr 2024

Sponsor / Collaborator

Isfahan University of Medical Sciences

CTRI/2019/05/019222

/ RecruitingPhase 1

A Comparative study comparing intensified treatment with Moxifloxacin/Pyrazinamide versus standard Anti-tubercular therapy for CNS Tuberculoma

Start Date27 May 2019

Sponsor / Collaborator-

ChiCTR-ONC-13003995

/ CompletedNot ApplicableIIT

Brain-CT position past uses in brain tumor surgery with tuberculosis

Start Date01 Dec 2013

Sponsor / Collaborator-

100 Clinical Results associated with Tuberculoma

100 Translational Medicine associated with Tuberculoma

0 Patents (Medical) associated with Tuberculoma

3,028

Literatures (Medical) associated with Tuberculoma

01 Feb 2025·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Tuberculous meningitis-related ischemic stroke: A retrospective study from a tertiary care hospital

Article

Author: Liang, Zhijian ; Deng, Xuhui ; Chen, Shengri ; Huang, Hua ; Huang, Qiuhui ; Wang, Xue

BackgroundPatients with tuberculous meningitis (TBM) are at high risk of ischemic stroke, and stroke is a poor prognosticator of TBM. However, reports regarding the predictors of stroke in TBM patients are scanty. The aim of this study was to investigate the clinical characteristics and predictors of tuberculous meningitis-related ischemic stroke (TBMRIS).MethodsThis retrospective study was conducted among TBM patients without traditional vascular risk factors from a tertiary care hospital between January 2017 and November 2022. Patients were divided into TBMRIS group and TBM-only group according to presence of stroke. Clinical, laboratory and radiological variables were compared between the two groups. Predictors of stroke were identified using binary logistic regression analysis.ResultsA total of 176 TBM patients were included in the study. Forty-nine patients with stroke were classified as TBMRIS group and 127 patients without stroke were classified as TBM-only group. In TBMRIS group, 41 (83.7 %) patients experienced stroke within 3 months after the onset of meningitis symptoms and 10 (20.4 %) patients presented silent stroke. Stroke occurred in basal ganglia in 57.1 % of patients. About 73.5 % of patients showed multiple stroke lesions and 38.8 % of patients had stroke involving multiple vascular territories. There were significant differences in focal neurological deficit, stage of meningitis, short-term outcome, serum sodium, cerebrospinal fluid (CSF) white cell count, CSF adenosine deaminase (ADA), CSF protein, leptomeningeal enhancement, tuberculoma between TBMRIS group and TBM-only group. Binary logistic regression analysis revealed that focal neurological deficit, CSF white cell count and leptomeningeal enhancement were the independent risk factors for stroke, and tuberculoma was negatively correlated with stroke.ConclusionMost of TBMRIS develop within 3 months after the onset of meningitis symptoms and basal ganglia is the most frequent site. Multiple stroke lesions and involvement of multiple vascular territories are commonly observed. Focal neurological deficit, CSF white cell count and leptomeningeal enhancement are the predictors of stroke in patients with TBM.

01 Feb 2025·Radiology Case Reports

Magnetic resonance imaging in diagnosing spinal cord tuberculoma: A case series and literature review

Article

Author: Zarrinttan, Armin ; Bilgin, Cem ; Kallmes, David F ; Ghozy, Sherief ; Fayisa, Shimalis

Spinal cord tuberculoma is a clinically significant form of extra-pulmonary tuberculosis, despite its rarity. It leads to considerable neurological deficits and morbidity. Accurate diagnosis and early intervention depend on radiologic imaging, typically MRI, which reveals T2 hypointensity with rim enhancement, forming a ``target sign'' characteristic of caseous stage tuberculoma. In this article, we present 3 cases of spinal cord tuberculoma without adjacent vertebral involvement; 2 cases affect the lower thoracic region, while one involves the cervical cord. All patients exhibited some degree of body weakness, which improved following the initiation of anti-tuberculosis treatment. Also, we discuss the role of MRI in diagnosing spinal cord tuberculoma, highlighting its characteristic findings, and review recent literature on the topic.

02 Jan 2025·Clinical and Experimental Optometry

Large choroidal tuberculoma simulating a choroidal melanoma as the first manifestation of disseminated tuberculosis

Article

Author: Bosco, González-Jáuregui-López ; Sotomayor-Toribio, Magdalena ; Sánchez-Vicente, José Luis ; Fernando, López-Herrero ; Montenegro-Quintana, Miguel Ángel ; Rodríguez Fernández, Carla

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Tuberculoma

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