The effect of transcutaneous auricular vagus nerve stimulation in reducing the burden of Atrial tachycardia/Atrial Fibrillation: a pilot study on feasibility, acceptability and safety

Start Date21 Dec 2024

Sponsor / Collaborator

Tehran University of Medical Sciences

IRCT20220516054874N17

/ RecruitingPhase 3IIT

Investigating the effect of rose hip alcoholic extract on the ventricular arrhythmia in heart failure patients with Implantable Cardioverter Defibrillator

Start Date05 Jul 2024

Sponsor / Collaborator

Mashhad University of Medical Sciences

IRCT20220516054874N16

/ RecruitingPhase 3IIT

Investigating the effect of pentoxifylline on ventricular arrhythmia in heart failure patients with Implantable Cardioverter Defibrillator

Start Date04 Jun 2024

Sponsor / Collaborator

Mashhad University of Medical Sciences

100 Clinical Results associated with Tachycardia, Paroxysmal

100 Translational Medicine associated with Tachycardia, Paroxysmal

0 Patents (Medical) associated with Tachycardia, Paroxysmal

2,145

Literatures (Medical) associated with Tachycardia, Paroxysmal

01 Sep 2025·Medical Gas Research

Application and progress of hyperbaric oxygen therapy in cardiovascular diseases

Review

Author: Li, Shaolong ; Du, Wenyin ; Tian, Menglin ; Yang, Sen ; Guo, Fuding ; Liao, Qiwei

Cardiovascular diseases remain the leading cause of death worldwide, underscoring the urgent need for additional therapeutic strategies to reduce their mortality rates. This review systematically outlines the historical development and recent advances of hyperbaric oxygen therapy in cardiovascular diseases, with a focus on its therapeutic mechanisms and clinical outcomes. Hyperbaric oxygen therapy enhances oxygen delivery to ischemic and reperfused tissues, promotes angiogenesis, and significantly suppresses oxidative stress, inflammatory cascades, and cardiomyocyte apoptosis, demonstrating multifaceted therapeutic potential in cardiovascular conditions. Specifically, hyperbaric oxygen therapy combined with reperfusion strategies has been shown to markedly improve left ventricular ejection fraction in acute myocardial infarction. In heart failure, it facilitates myocardial repair and enhances cardiac function. For arrhythmias, hyperbaric oxygen therapy effectively reduces the frequency and duration of premature ventricular contractions and paroxysmal tachycardia, while mitigating the risk of neurological complications following atrial fibrillation ablation. Furthermore, hyperbaric oxygen therapy preconditioning in cardiac surgery has demonstrated improvements in left ventricular stroke work, reductions in postoperative myocardial injury, and a decrease in related complications. Despite its promising applications, the widespread adoption of hyperbaric oxygen therapy remains hindered by the lack of standardized treatment protocols and high-quality evidence from rigorous clinical trials. In conclusion, this review underscores the potential value of hyperbaric oxygen therapy in the cardiovascular domain while highlighting the need for further optimization of therapeutic parameters and exploration of its synergistic effects with conventional therapies to provide clearer guidance for clinical implementation.

01 May 2025·Radiology Case Reports

Complex presentation of Bouveret syndrome: Gastric outlet obstruction and septic complications

Article

Author: Grabill, Nathaniel ; Ayinde, Bolaji ; Louis, Mena ; Gibson, Brian

Bouveret syndrome, a rare form of gastric outlet obstruction, occurs when a large gallstone migrates through a cholecystoenteric fistula into the duodenum, causing obstruction. We report a 31-year-old female who initially presented with nausea, vomiting, and abdominal pain. Imaging identified a large, calcified gallstone, a hepatic abscess, and acute cholecystitis. Initial treatment involved drainage of the hepatic abscess and antibiotics, with plans for elective cholecystectomy. Three years later, she returned with recurrent symptoms, including early satiety, significant weight loss, and gastric outlet obstruction. Endoscopy confirmed duodenal obstruction, and further imaging revealed a cholecystoduodenal fistula. She underwent an open cholecystectomy with fistula excision, duodenal repair, and nasojejunal feeding tube placement. Her postoperative recovery was smooth, with a gradual return to enteral nutrition. This report presents essential diagnostic and treatment approaches for Bouveret syndrome, including the roles of imaging, endoscopy, and surgery in managing complex cases. Early recognition and a coordinated, individualized treatment plan are crucial to optimizing outcomes in this rare condition.

01 May 2025·International Journal of Surgery Case Reports

Surgical treatment of Bouveret Syndrome without completion cholecystectomy

Article

Author: McCloud, Anthony ; Eisner, Joseph ; Tackett, Carrie ; Stahl, Patrick

INTRODUCTION AND IMPORTANCEBouveret syndrome, the rarest variant of gallstone ileus, occurs due to the passage of a gallstone into the gastrointestinal tract via a bilioenteric fistula, leading to gastric outlet obstruction. This condition represents less than 0.1 % of all mechanical bowel obstructions, predominantly affecting elderly females. Its nonspecific symptoms, including nausea, vomiting, and abdominal pain, often result in delayed diagnosis and significant mortality rates ranging from 12 % to 30 %. Historically, management involves a two-stage surgical approach: initial stone removal followed by interval cholecystectomy and fistula repair to prevent recurrence.CASE PRESENTATIONThis report presents two cases of younger patients with Bouveret syndrome managed with a single-stage surgical approach consisting of gallstone removal without subsequent cholecystectomy or fistula repair. Both patients remained symptom-free for two years postoperatively.CLINICAL DISCUSSIONThese findings challenge the necessity of routine interval cholecystectomy and fistula closure, particularly in patients without recurrent biliary symptoms. We discuss the implications of a simplified surgical strategy, highlighting the potential for spontaneous fistula closure or adaptation of bile drainage pathways.CONCLUSIONWhile current literature supports interval surgery for younger patients to mitigate long-term risks, these cases suggest that selective management may reduce morbidity without compromising outcomes. Further research is needed to refine guidelines for the surgical management of Bouveret syndrome.

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