Last update 01 Nov 2024

Radiation proctitis

Last update 01 Nov 2024

Basic Info

Synonyms

PROCTITIS RADIATION, Radiation induced proctitis, Radiation proctitis

+ [8]

Introduction

Radiation proctitis is a rare rectal disease directly induced by pelvic radiotherapy and characterized by rectal bleeding, change in bowel habits, tenesmus and sepsis.

Drugs associated with Radiation proctitis

Montelukast sodium

Target

CysLT

Mechanism

CysLT antagonists

Active Org.

Usun BioStartup [+5]

Originator Org.

Merck & Co., Inc.

Active Indication

Rhinitis, Allergic [+11]

Inactive Indication

Acute asthma [+11]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date20 Feb 1998

Budesonide

Target

Mechanism

GR agonists

Active Org.

Calliditas Therapeutics AB [+28]

Originator Org.

AstraZeneca Pharmaceuticals Co. Ltd.

Active Indication

Glomerulonephritis, IGA [+9]

Inactive Indication

Acute Graft Versus Host Disease [+19]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date14 Feb 1994

Human umbilical cord mesenchymal stem cells(Jiangsu Topcel-KH Pharmaceutical)

Target-

Mechanism

Cell replacements

Active Org.

Jiangsu Tuohong Kangheng Pharmaceutical Co., Ltd.Startup

Originator Org.

Jiangsu Tuohong Kangheng Pharmaceutical Co., Ltd.Startup

Active Indication

Perianal fistula due to Crohn's disease [+4]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Radiation proctitis

CTRI/2024/08/071766 / Not yet recruitingPhase 2/3IIT

Comparison of efficacy of four percent formalin rectal application and argon plasma coagulation in patients of chronic radiation proctopathy with intractable rectal bleeding– An open label Randomized Controlled Trial - Nil

Start Date14 Aug 2024

Sponsor / Collaborator-

NCT06087718 / Not yet recruitingNot ApplicableIIT

Introduction of the Maastro Applicator for Endoluminal Boosting in Rectal Cancer: a Pilot Study

The goal of this interventional pilot trial is to confirm that Maastro endoluminal HDR ( High Dose Radiation) contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in patients with rectal cancer. Participants will be treated with chemoradiotherapy and an endoluminal boost with the Maastro applicator.

Start Date01 Jul 2024

Sponsor / Collaborator

Maastro

[+1]

CTR20241812 / RecruitingPhase 1/2

评价TH-SC01治疗慢性放射性直肠炎的安全性和初步有效性I/II期研究

[Translation] Phase I/II study to evaluate the safety and preliminary efficacy of TH-SC01 in the treatment of chronic radiation proctitis

主要目的：评价TH-SC01治疗慢性放射性直肠炎患者的安全性和耐受性。次要目的：初步观察TH-SC01治疗慢性放射性直肠炎的疗效。

[Translation]

Primary objective: To evaluate the safety and tolerability of TH-SC01 in the treatment of patients with chronic radiation proctitis. Secondary objective: To preliminarily observe the efficacy of TH-SC01 in the treatment of chronic radiation proctitis.

Start Date24 May 2024

Sponsor / Collaborator

Jiangsu Tuohong Kangheng Pharmaceutical Co., Ltd.Startup

100 Clinical Results associated with Radiation proctitis

100 Translational Medicine associated with Radiation proctitis

0 Patents (Medical) associated with Radiation proctitis

735

Literatures (Medical) associated with Radiation proctitis

01 Oct 2024·Journal of the Academy of Consultation-Liaison Psychiatry

Novel Use of a Tricyclic Antidepressant to Address Depression and Quality of Life in a Case of Radiation Proctitis

Letter

Author: Buckley, Patrick ; Hale, Elizabeth

01 Sep 2024·International Journal of Urology

Radiation proctitis after iodine‐125 low‐dose‐rate prostate brachytherapy utilizing SpaceOAR hydrogel

Article

Author: Nakamura, Saori ; Hiramatsu, Aya ; Noguchi, Tetsuo ; Nishimura, Kota ; Yanagida, Wahei ; Fukagai, Takashi ; Yamatoya, Jin ; Morita, Masashi ; Tanabe, Mayo ; Lederer, John L.

ObjectiveWe retrospectively evaluated the efficacy of combining the SpaceOAR (SOAR) hydrogel with prostate brachytherapy, using colonoscopy findings to assess for radiation proctitis.MethodsAmong 731 patients undergoing iodine‐125 low‐dose‐rate prostate brachytherapy (LDR‐BT), SOAR was utilized in 394 patients (53.9%). Colonoscopy was performed for 97 patients (13.3%) to assess the presence, location, condition, and treatment of radiation proctitis. We also investigated treatment factors associated with the occurrence of radiation proctitis.ResultsRadiation proctitis was observed in 57 patients (7.8%) and 17 (2.3%) were treated with argon plasma coagulation (APC). The incidence of radiation proctitis was 12.2% in the non‐SOAR and 4.1% in the SOAR group (p < 0.001). In the non‐SOAR group, the incidence of radiation proctitis was 6.6% for LDR‐BT monotherapy and increased to 22.0% when combined with external beam radiation therapy (EBRT) (p = 0.001). However, in the SOAR group, these rates significantly decreased to 3.3% and 5.7% for monotherapy and combination therapy, respectively (p = 0.035, p < 0.001). With SOAR, inflammation was observed directly above the DL in most patients (87.5%), and only one patient (6.3%) required APC. The absence of SOAR (p < 0.001, HR = 0.29) and the concurrent use of EBRT (p = 0.018, HR = 2.87) were identified as significant risk factors for the occurrence of radiation proctitis.ConclusionThe use of SOAR significantly reduced the incidence of radiation proctitis in patients undergoing LDR‐BT monotherapy and combined EBRT. Inflammation primarily occurred directly above the DL; further examination is necessary to clarify its cause.

01 Sep 2024·Digestive Diseases and Sciences

Feel the Burn: RFA for Chronic Radiation Proctitis

Article

Author: De Sena, Gabriele ; Lauro, Augusto ; Bentivoglio, Davide ; Docimo, Ludovico ; Centore, Davide ; Gambardella, Claudio ; Porpora, Danilo ; Mongardini, Federico Maria ; Mauro, Maria ; Napolitano, Vincenzo ; Brusciano, Luigi

Chronic radiation proctitis, although relatively rare, can be the source of severe comorbidity in patients who had undergone prior radiotherapy for pelvic malignancy. Although current treatments for radiation proctitis include argon plasma coagulation, heater probe, bipolar neodymium/yttrium aluminum garnet (Nd: YAG) lasers, these interventions are often burdened by the frequent occurrence of rectal ulcerations and stenosis. Since radiofrequency ablation (RFA) is frequently used to ablate esophageal malignancy and pre-malignancy, we report the efficacy of RFA using through the scope system in two patients with rectal bleeding due to radiation proctitis. In both cases, the procedure was well-tolerated with hemostasis achieved after 1 or 2 sessions of RFA. Mucosal re-epithelialization was observed in areas of previous bleeding with no stenosis or ulceration observed at follow-up.

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