Last update 01 Nov 2024

Gingival Hyperplasia

Last update 01 Nov 2024

Basic Info

Synonyms

GINGIVAL HYPERPLASIA, GUM HYPERPLASIA, Gingival Hyperplasia

+ [30]

Introduction

Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)

Clinical Trials associated with Gingival Hyperplasia

NCT05706480 / RecruitingNot ApplicableIIT

Assessment of Gingival Thickness Using Colored Periodontal Probe Assessment Method: A Cross-Sectional Study

the accuracy of different assessment methods of the gingival tissue thickness can be controversial affecting their correct classification and the techniques of gingival tissue management in case of mucogingival problems.
Aim: The aim of this study is to evaluate the accuracy of different assessment methods of measuring GT and to classify into the different gingival phenotypes.

Start Date01 Feb 2025

Sponsor / Collaborator

Misr International University

RBR-6jts634 / Not yet recruitingPhase 4IIT

Clinical study of a formulation containing Phtalox® for the prevention and control of Periodontal Disease

Start Date01 Mar 2022

Sponsor / Collaborator

Universidade Federal De Alfenas

[+1]

NCT04542486 / CompletedNot ApplicableIIT

Clinical Efficacy of Soft Tissue Trimmer on Postoperative Pain and Wound Healing When Compared to the Conventional Surgical Excision of Gingival Hyperplasia: A Randomized Clinical Trial

Postoperative pain and wound healing are compared after using conventional scalpel technique in comparison with the intervention which is using Soft tissue Trimmer for cases of gingival hyperplasia.

Start Date28 Jan 2021

Sponsor / Collaborator

Cairo University

100 Clinical Results associated with Gingival Hyperplasia

100 Translational Medicine associated with Gingival Hyperplasia

0 Patents (Medical) associated with Gingival Hyperplasia

1,433

Literatures (Medical) associated with Gingival Hyperplasia

01 Nov 2024·Pediatric Drugs

Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review

Review

Author: Alimadadi, Hosein ; Dashti-Khavidaki, Simin ; Moghadamnia, Marjan

BACKGROUNDImmunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplantation (LT). Typically, immunosuppressive protocols for pediatric LT patients rely on calcineurin inhibitors (CNIs). While inhibitors of mammalian target of rapamycin (mTOR) have demonstrated beneficial outcomes in adult recipients of liver allografts, such as improved renal function post-LT, their application in pediatric liver transplant recipients is a subject of debate due to uncertain efficacy and potential adverse effects.OBJECTIVESThis review evaluates the potential roles of mTOR inhibitors in the context of pediatric LT patients.METHODSThis systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for conduct and reporting. Databases until 31 August 2023 were searched using specific terms and keywords. All clinical studies focusing on mTOR inhibitors in pediatric LT were included.RESULTSOut of 888 identified articles, 30 studies, involving 386 children who had undergone liver transplantation and received mTOR-inhibitor-based immunosuppressive regimens, met the inclusion criteria. The beneficial impacts of switching from a CNI to an mTOR inhibitor or adding an mTOR inhibitor to CNI-reduced immunosuppression in LT pediatric patients with impaired kidney function are controversial, and high-powered clinical studies are need. It appears that enhancing immunosuppression by adding an mTOR inhibitor to CNI is helpful for pediatric LT recipients who are experiencing refractory acute rejection or chronic rejection. mTOR-inhibitor-containing regimens failed to reduce the occurrence of post-transplant lymphoproliferative disorders (PTLD) among children with LT that may be due to concomitant high CNI concentration among studied patients. The effectiveness of mTOR inhibitors in treating PTLD remains uncertain; however, in patients with PTLD who are at high risk of rejection, mTOR inhibitors may be administered. Conversion to or the addition of mTOR inhibitors to maintenance immunosuppression seems to be suitable for pediatric patients who received a transplant due to hepatic malignancies such as hepatoblastoma or hepatocellular carcinoma or for those with post-transplant primary or recurrent malignancies. Switching to an mTOR inhibitor may improve some CNI-related adverse effects such as gingival hyperplasia, neurotoxicity, nephropathy, hypertrophic cardiomyopathy, or thrombotic microangiopathy.CONCLUSIONAlthough the exact role of mTOR inhibitors among pediatric patients who have received a liver transplant needs further study, two algorithms are presented in this review to guide conversion from CNIs to mTOR inhibitors or the addition of mTOR inhibitor to a CNI-minimization immunosuppressive regimen for pediatric patients who may benefit from this class of drugs. This review mainly consisted of retrospective studies with inadequate sample sizes and lacked a control group, which represents the main limitation of this study.

17 Oct 2024·International journal of dermatology

Cemiplimab-induced gingival hyperplasia.

Letter

Author: Jaenke Hill, Madison ; Driscoll, Marcia ; Chen, Maggie

01 Oct 2024·Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

Localized juvenile spongiotic gingival hyperplasia: a case report.

Article

Author: Yang, Jingmei ; Wu, Yafei ; Zeng, Xin ; Zhao, Huan

Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a kind of gingival hyperplasia with unique pathological manifestations. Its clinical manifestations are atypical, and the etiology and pathogenesis are unclear. No case report was reported in China. The diagnosis of this disease mainly relies on pathological testing, and recurrence may occur after treatment. The best treatment method still lacks medical evidence. This paper reports a case of LJSGH in a teenager and summarizes its clinical, pathological, and treatment through literature review. This work provides a reference for the diagnosis and treatment of this disease.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Gingival Hyperplasia

Basic Info

Related

Analysis