Congenital hypoplasia of lung

WEST CHESTER, Pa.--(BUSINESS WIRE)-- Molecular Targeting Technologies, Inc. (MTTI), will update findings on both 177Lu-EBTATE clinical and 225Ac-EBTATE preclinical work during the 2024 SNMMI meeting in Toronto June 8-11 (exhibition booth #1819). 177Lu-EBTATE® an EvaThera drug, is the first patented long-acting peptide targeted radiotherapeutic drugs. It selectively targets and binds to somatostatin receptor 2 on neuroendocrine and other tumors, which are then killed by the radionuclide payload. Evans blue in EBTATE binds to serum albumin, extending in vivo circulatory half-life and tumor residence time, enabling effective use of significantly lower radiopharmaceutical activity and fewer dosing cycles vs. the current standard of care (SOC). These benefits are also evident in recent studies of the 225Ac-EBTATE homolog. Professor Zhaohui Zhu, MD, Peking Union Medical College Hospital, reflected “In our 3-year follow up on 30 patients* with metastatic neuroendocrine tumors (mNETs), 177Lu-EBTATE demonstrated good safety, with no nephro- or hepatoxicity and 86% disease control rate using 60% less radioactivity than 177Lu-DOTATATE. We observed low incidence of grade 3 hematoxicity (3.4% vs 15% of reported SOC) and no long-term nephrotoxicity of any grade.” The study “Long acting 225Ac-EBTATE is highly efficacious against somatostatin receptor-2-positive small-cell lung cancer (SCLC)**” has been accepted for presentation at 2024 SNMMI. Professor Humphrey Fonge of the University of Saskatchewan commented, "225Ac-EBTATE (2x 30 kBq administered 10 days apart) was effective against SCLC with 80% complete remissions and 100% survival. Treatment yielded a 2-fold greater tumor growth inhibition when compared with 225Ac-DOTATATE, at 60% less administered radioactivity. Toxicity, as measured by body weight, blood counts, and chemistry showed that 225Ac-EBTATE was well tolerated at a highly effective dose. 225Ac-EBTATE shows great promise against SCLC." Chris Pak, President & CEO of MTTI commented: “We are pleased to learn that 177Lu-EBTATE exhibited no safety concerns and was effective at a lower dose than SOC in mNET patients. We are also encouraged that 225Ac-EBTATE out-performed 225Ac-DOTATATE, providing a 2-fold greater tumor growth inhibition in preclinical findings using a much lower dose of radioactivity. We look forward to advancing our clinical trials with these radiotherapeutic drugs in small-cell lung and other cancers.” Molecular Targeting Technologies, Inc. (MTTI). MTTI is a private, clinical stage biotech developing targeted radiotherapeutics for rare cancers. MTTI is committed to building value by translating innovative radiopharmaceuticals to improve human health. For more information: . *Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors. Theranostics 2022; 12: 6437-6445 **The data will be presented in 2024 SNMMI. Fabrice Njotu, Humphrey Fonge et al. of the University of Saskatchewan, and Molecular Targeting Technologies, Inc. View source version on businesswire.com: Contacts Chris Pak, Email: cpak@mtarget.com Source: Molecular Targeting Technologies, Inc. View this news release online at:

Researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung. University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body's response to limited oxygen and regulates blood vessel disease of the lung. By combing through genomes of more than 20,000 individuals in the U.S., France, England and Japan and combining the results with molecular studies in the lab, the team discovered a shared genetic trait that could predict a higher risk of small lung vessel disease called pulmonary hypertension and its more severe form, pulmonary arterial hypertension, and influence the development of drug therapies that target the body's response to limited oxygen. The findings were published this week in Science Translational Medicine. "This new level of knowledge will help identify people who may be at a higher genetic risk of pulmonary hypertension and jump-start precision medicine practices to offer customized treatments," said senior author Stephen Chan, M.D., Ph.D., a cardiologist who serves as the Vitalant Chair in Vascular Medicine and director of the Vascular Medicine Institute at Pitt. Pulmonary hypertension encompasses a range of conditions of various causes that manifest in high blood pressure in the arteries of the lung and the right side of the heart. The disease is accompanied by a decreased supply of oxygen to the lung tissue and the blood, is chronic and deadly, and its molecular origins and genetic background remain unsolved. Using a combined approach of genomics and biochemistry, the Chan lab found a gene pair that had an important function in regulating blood vessel metabolism and disease. This gene pair included a long non-coding RNA molecule -- a messenger that facilitates the transformation of the body's genetic code into protein products -- and a protein binding partner, and their interaction was frequently active in cells exposed to low oxygen compared to normal cells. Taking the findings a step further, the team discovered that a single DNA letter change directing expression of this RNA-protein pair under low oxygen conditions was associated with a higher genetic risk of pulmonary hypertension across diverse patient populations. According to Chan, pulmonary hypertension is a borderline orphan disease, and the limited number of patients with pulmonary hypertension makes it challenging to find genetic variations that are rare but still impactful enough to eclipse individual differences. With that in mind, Pitt scientists turned to collaborators around the globe and to public research datasets such as All of Us -- a nationwide health registry funded by the National Institutes of Health -- to ensure that the findings are relevant across a diverse global population. Chan hopes that his findings will spur the development of targeted therapies relevant to oxygen sensitivity in blood vessel lining and that their pending patent application will contribute to the growth on an entirely new field of epigenetic and RNA drug therapeutics that work not by manipulating the genome but by changing how it is being read. Other authors of the study include Yi-Yin Tai, M.S., Qiujun Yu, M.D., Ph.D., Ying Tang, M.S., Wei Sun, M.D., Neil J. Kelly, M.D., Ph.D., Jingsi Zhao, M.S., Yassmin Al Aaraj M.D., M.P.H., Vinny Negi, Ph.D., Mingjun Liu, Ph.D., Catherine G. Corey, Frances Belmonte, Taijyu Satoh, M.D., Yingze Zhang, Ph.D., Dennis McNamara, M.D., Gang Li, Ph.D., Bing Wang, M.D., Ph.D., Sruti Shiva, Ph.D., Brett Kaufman, Ph.D., Delphine Gomez, Ph.D., Mehdi Nouraie, Ph.D., all of Pitt, as well as centers from the Indiana University School of Medicine, University of Arizona College of Medicine, NHS Blood and Transplant (UK), CNRS (France), and Tohoku University Graduate School of Medicine (Japan).